Peiying Shan
Research Associate 2Cards
About
Research
Publications
2025
ELF4 bridges transcriptional and translational outputs to regulate inflammatory T Cells 3617
Bender M, Olyha S, Bucklin M, Siddapureddy S, Miranda V, Johnston A, Attanasio J, Kohli J, Babu D, Kumar U, Maher T, Shan P, Pan J, Muise A, Myers S, Lucas C. ELF4 bridges transcriptional and translational outputs to regulate inflammatory T Cells 3617. The Journal Of Immunology 2025, 214 DOI: 10.1093/jimmun/vkaf283.1396.Peer-Reviewed Original ResearchCD4+ T cellsT cellsCD4+ T cell regulationMemory CD4+ T cellsActivation of naive T cellsNaive T cellsInflammatory T cellsLymphocytic choriomeningitis virusIntegrated stress responseT cell regulationIFNg productionCytokine productionInterferon-gammaTh17 differentiationCap-dependent translationInflammatory potentialImmune systemInhibition of cap-dependent translationIFNGProduction of factorsCD4Cell culturesGlobal lossInfectionStress response
2024
Mouse Models of Hereditary Xerocytosis-Associated PIEZO1 Mutations Reveal Genotype-Phenotype Differences in Hematological Defects and Iron Loading
Finberg K, Peres Diaz L, Shan P, Chua E, Lalwani K, Gallagher P. Mouse Models of Hereditary Xerocytosis-Associated PIEZO1 Mutations Reveal Genotype-Phenotype Differences in Hematological Defects and Iron Loading. Blood 2024, 144: 3851-3851. DOI: 10.1182/blood-2024-203740.Peer-Reviewed Original ResearchRed cell distribution widthHereditary xerocytosisSpleen weight/body weight ratioRed blood cell countMean corpuscular volumeCompared to wild-typeHematological defectsMouse modelHeart weight/body weight ratioWild-typeIron loadingComplete blood count analysisRed blood cell turnoverSerum transferrin saturationC57BL/6 genetic backgroundSerum hepcidin levelsLiver iron loadingYoung adult miceGenotype-phenotype differencesCell distribution widthMean corpuscular hemoglobinGain-of-function mutationsBlood count analysisNon-heme iron concentrationsRed cell indicesPI3Kγ in B cells promotes antibody responses and generation of antibody-secreting cells
Lanahan S, Yang L, Jones K, Qi Z, Cabrera E, Cominsky L, Ramaswamy A, Barmada A, Gabernet G, Uthaya Kumar D, Xu L, Shan P, Wymann M, Kleinstein S, Rao V, Mustillo P, Romberg N, Abraham R, Lucas C. PI3Kγ in B cells promotes antibody responses and generation of antibody-secreting cells. Nature Immunology 2024, 25: 1422-1431. PMID: 38961274, PMCID: PMC12449845, DOI: 10.1038/s41590-024-01890-1.Peer-Reviewed Original ResearchAntibody-secreting cellsMemory B cellsB cellsKinase activity-dependent mannerDifferentiation of antibody-secreting cellsAntibody responseGeneration of antibody-secreting cellsInborn errors of immunityActivity-dependent mannerMouse immunization modelFate choiceT cell-dependent antigensToll-like receptor activationTranscriptional programsB cell biologyPhosphoinositide 3-kinase-gammaErrors of immunityNaive B cellsTransduce signalsActivated B cellsB lineage cellsRobust antibody responsesHumoral defectsHumoral immunityReceptor activation
2023
Identification of a Novel Gene Regulatory Element in Human Erythroid Progenitor Cells
Schulz V, Lezon-Geyda K, Shan P, Papoin J, Narla M, Steiner L, Blanc L, Palis J, Gallagher P. Identification of a Novel Gene Regulatory Element in Human Erythroid Progenitor Cells. Blood 2023, 142: 9. DOI: 10.1182/blood-2023-186046.Peer-Reviewed Original ResearchErythroid progenitor cellsActive enhancersEarly erythropoiesisChIP-seqRegulatory elementsGene expressionATAC-seqRUNX motifsGATA motifSingle nucleotide polymorphismsProgenitor cellsGATA1 bindingDisease genesEnhancer regionErythroid lineageTissue-specific transcription factorsNovel gene regulatory elementsNovel enhancer regionErythrocyte traitsGenome-wide association studiesDirect tissue-specific expressionNovel regulatory elementGene regulatory elementsHuman erythroid progenitor cellsTerminal erythroid differentiationCorrection: Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3
Zhang X, Shan P, Otterbein L, Alam J, Flavell R, Davis R, Choi A, Lee P. Correction: Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. Journal Of Biological Chemistry 2023, 299: 105304. PMID: 37826982, PMCID: PMC10570935, DOI: 10.1016/j.jbc.2023.105304.Peer-Reviewed Original Research
2015
Innate Immune Ligands MIF and D-DT Cooperate to Regulate DNA Repair and Cellular Senescence in the Lung and are Decreased in COPD
Sauler M, Leng L, Shan P, Piecychna M, Zhang Y, Herazo-Maya J, Tedrow J, Kaminski N, Bucala R, Lee P. Innate Immune Ligands MIF and D-DT Cooperate to Regulate DNA Repair and Cellular Senescence in the Lung and are Decreased in COPD. American Journal Of Respiratory And Critical Care Medicine 2015, 191: a5325-a5325. DOI: 10.1164/ajrccm-conference.2015.191.1_meetingabstracts.a5325.Peer-Reviewed Original ResearchEndothelial TLR4 Expression Confers TLR4 Deficiency Resistance to Hyperoxia Induced Lung Injury
Shan P, Zhang X, Zhang Y, Lee P. Endothelial TLR4 Expression Confers TLR4 Deficiency Resistance to Hyperoxia Induced Lung Injury. American Journal Of Respiratory And Critical Care Medicine 2015, 191: a6098-a6098. DOI: 10.1164/ajrccm-conference.2015.191.1_meetingabstracts.a6098.Peer-Reviewed Original ResearchA Novel Hsp70-TLR4-Nox3 Axis in Emphysema
Zhang Y, Shan P, Jiang G, Lee P. A Novel Hsp70-TLR4-Nox3 Axis in Emphysema. American Journal Of Respiratory And Critical Care Medicine 2015, 191: a3879-a3879. DOI: 10.1164/ajrccm-conference.2015.191.1_meetingabstracts.a3879.Peer-Reviewed Original Research
2013
MIF Protects Against Hyperoxic Lung Injury
Sauler M, Shan P, Volkova M, Zheng Y, Leng L, Bucala R, Lee P. MIF Protects Against Hyperoxic Lung Injury. American Journal Of Respiratory And Critical Care Medicine 2013, 187: a3366-a3366. DOI: 10.1164/ajrccm-conference.2013.187.1_meetingabstracts.a3366.Peer-Reviewed Original ResearchMIF Deficiency is a Risk Factor for COPD
Sauler M, Shan P, Leng L, Qin L, Trentalange M, Chang S, Allore H, Bucala R, Lee P. MIF Deficiency is a Risk Factor for COPD. American Journal Of Respiratory And Critical Care Medicine 2013, 187: a1100-a1100. DOI: 10.1164/ajrccm-conference.2013.187.1_meetingabstracts.a1100.Peer-Reviewed Original Research