Peiying Shan
Research Associate 2Cards
About
Research
Publications
2024
PI3Kγ in B cells promotes antibody responses and generation of antibody-secreting cells
Lanahan S, Yang L, Jones K, Qi Z, Cabrera E, Cominsky L, Ramaswamy A, Barmada A, Gabernet G, Uthaya Kumar D, Xu L, Shan P, Wymann M, Kleinstein S, Rao V, Mustillo P, Romberg N, Abraham R, Lucas C. PI3Kγ in B cells promotes antibody responses and generation of antibody-secreting cells. Nature Immunology 2024, 25: 1422-1431. PMID: 38961274, PMCID: PMC12449845, DOI: 10.1038/s41590-024-01890-1.Peer-Reviewed Original ResearchAntibody-secreting cellsMemory B cellsB cellsKinase activity-dependent mannerDifferentiation of antibody-secreting cellsAntibody responseGeneration of antibody-secreting cellsInborn errors of immunityActivity-dependent mannerMouse immunization modelFate choiceT cell-dependent antigensToll-like receptor activationTranscriptional programsB cell biologyPhosphoinositide 3-kinase-gammaErrors of immunityNaive B cellsTransduce signalsActivated B cellsB lineage cellsRobust antibody responsesHumoral defectsHumoral immunityReceptor activation
2023
Correction: Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3
Zhang X, Shan P, Otterbein L, Alam J, Flavell R, Davis R, Choi A, Lee P. Correction: Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. Journal Of Biological Chemistry 2023, 299: 105304. PMID: 37826982, PMCID: PMC10570935, DOI: 10.1016/j.jbc.2023.105304.Commentaries, Editorials and Letters
2018
Mitochondrial Proteins Regulate Experimental Pulmonary Hypertension
Bazan I, Marshall J, Kim S, Shan P, Lee P. Mitochondrial Proteins Regulate Experimental Pulmonary Hypertension. American Journal Of Respiratory And Critical Care Medicine 2018, 197: a2070-a2070. DOI: 10.1164/ajrccm-conference.2018.197.1_meetingabstracts.a2070.Peer-Reviewed Original ResearchMacrophage Migration Inhibitory Factor Protects Against Cigarette Smoke-Induced Senescence
Kim S, Bazan I, Shan P, Sauler M, Leng L, Bucala R, Lee P. Macrophage Migration Inhibitory Factor Protects Against Cigarette Smoke-Induced Senescence. American Journal Of Respiratory And Critical Care Medicine 2018, 197: a4634-a4634. DOI: 10.1164/ajrccm-conference.2018.197.1_meetingabstracts.a4634.Peer-Reviewed Original Research
2017
TLR4-Mediated Epigenetic and Senescence Mechanisms in COPD
Hwangbo C, Shan P, Zhang Y, Zhang X, Lee P. TLR4-Mediated Epigenetic and Senescence Mechanisms in COPD. American Journal Of Respiratory And Critical Care Medicine 2017, 195: a7489-a7489. DOI: 10.1164/ajrccm-conference.2017.195.1_meetingabstracts.a7489.Peer-Reviewed Original ResearchEndothelial TLR4 is Sufficient Against TLR4 Deficiency Induced Pulmonary Emphysema Through STC1
Shan P, Zhang X, Zhang Y, Lee P. Endothelial TLR4 is Sufficient Against TLR4 Deficiency Induced Pulmonary Emphysema Through STC1. American Journal Of Respiratory And Critical Care Medicine 2017, 195: a6935-a6935. DOI: 10.1164/ajrccm-conference.2017.195.1_meetingabstracts.a6935.Peer-Reviewed Original ResearchSialic Acid-Binding Immunoglobulin-Like Lectin E (Siglec-E) Plays an Important Role in Inflammatory and Emphysematous Responses in Mice
Chen Z, Shan P, Kumagai T, Zhang L, Lee P, Zhang F, Tiemeyer M, Mei Z, Wang Y, Zhou L, Bochner B, Crocker P, Zheng T, Zhu Z. Sialic Acid-Binding Immunoglobulin-Like Lectin E (Siglec-E) Plays an Important Role in Inflammatory and Emphysematous Responses in Mice. American Journal Of Respiratory And Critical Care Medicine 2017, 195: a7368-a7368. DOI: 10.1164/ajrccm-conference.2017.195.1_meetingabstracts.a7368.Peer-Reviewed Original ResearchGlycoprotein Stanniocalcin 1-Mediated Cellular Glycolysis and Mitochondria Biogenesis is Dependent Upon TLR4
Zhang Y, Shan P, Lee P. Glycoprotein Stanniocalcin 1-Mediated Cellular Glycolysis and Mitochondria Biogenesis is Dependent Upon TLR4. American Journal Of Respiratory And Critical Care Medicine 2017, 195: a6916-a6916. DOI: 10.1164/ajrccm-conference.2017.195.1_meetingabstracts.a6916.Peer-Reviewed Original Research
2016
Endothelial TLR4 Regulates DNA Damage, Genome Stability and Senescence During Oxidant Stress
Zhang Y, Min J, Shan P, Zhang X, Lee P. Endothelial TLR4 Regulates DNA Damage, Genome Stability and Senescence During Oxidant Stress. American Journal Of Respiratory And Critical Care Medicine 2016, 193: a2326-a2326. DOI: 10.1164/ajrccm-conference.2016.193.1_meetingabstracts.a2326.Peer-Reviewed Original ResearchToll-Like Receptor 4 Mediates the Protective Effects of VEGF in Lung Endothelium
Zhang Y, Takyar S, Shan P, Lee P. Toll-Like Receptor 4 Mediates the Protective Effects of VEGF in Lung Endothelium. American Journal Of Respiratory And Critical Care Medicine 2016, 193: a4796-a4796. DOI: 10.1164/ajrccm-conference.2016.193.1_meetingabstracts.a4796.Peer-Reviewed Original Research