Nick Buitrago-Pocasangre, MSc
Neuroimmunology Project ManagerDownloadHi-Res Photo
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Contact Info
Hafler Lab
300 GEORGE ST
NEW HAVEN, Connecticut 06510
United States
Education
MSc
University of Hartford, Neuroscience (2020)
University of Hartford, Neuroscience (2020)
BS
UConn, Psychology (2016)
UConn, Psychology (2016)
About
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Titles
Neuroimmunology Project Manager
Departments & Organizations
Education & Training
- MSc
- University of Hartford, Neuroscience (2020)
- BS
- UConn, Psychology (2016)
Research
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Overview
Medical Research Interests
Autoimmune Diseases; Blood Cells; Brain; Central Nervous System; Immune System Diseases; Multiple Sclerosis; Nervous System Diseases; Neurosciences
ORCID
0000-0002-1333-4435- View Lab Website
Halfer Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Nick Buitrago-Pocasangre's published research.
Research Interests
Research topics Nick Buitrago-Pocasangre is interested in exploring.
David A. Hafler, MD, FANA
Erin Longbrake, MD, PhD
Albert C Shaw, MD, PhD
Antonella Bacchiocchi
Benjamin Y. Lu, MD, PhD
Fangyong Li, MS, MPH
Multiple Sclerosis
Publications
2025
Transcriptomic profiling after B-cell depletion reveals central and peripheral immune cell changes in multiple sclerosis
Wei J, Moon J, Yasumizu Y, Zhang L, Raddassi K, Buitrago-Pocasangre N, Deerhake M, Strauli N, Chen C, Herman A, Pedotti R, Raposo C, Yim I, Pappalardo J, Longbrake E, Sumida T, Axisa P, Hafler D. Transcriptomic profiling after B-cell depletion reveals central and peripheral immune cell changes in multiple sclerosis. Journal Of Clinical Investigation 2025, 135: e182790. PMID: 40067358, PMCID: PMC12126227, DOI: 10.1172/jci182790.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsB-cell depletionImmune landscapeMultiple sclerosisAnti-CD20-mediated B-cell depletionPeripheral CD4+ T cell populationsEffect of B cell depletionB cell depletion treatmentCD4+ T cell populationB cell depletion therapyCerebrospinal fluidCD4+ T cellsTreatment of early diseaseCD16+ monocytesImmune cell changesImmune cell subsetsT cell populationsPeripheral blood monocytesFlow cytometry-based methodTNF-a mRNACell type-specific changesCell subsetsT cellsImmunological changesAutoimmune activityB cells
2024
Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma
Lu B, Lucca L, Lewis W, Wang J, Nogueira C, Heer S, Rayon-Estrada V, Axisa P, Reeves S, Buitrago-Pocasangre N, Pham G, Kojima M, Wei W, Aizenbud L, Bacchiocchi A, Zhang L, Walewski J, Chiang V, Olino K, Clune J, Halaban R, Kluger Y, Coyle A, Kisielow J, Obermair F, Kluger H, Hafler D. Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma. Nature Immunology 2024, 26: 82-91. PMID: 39609626, PMCID: PMC12285569, DOI: 10.1038/s41590-024-02023-4.Peer-Reviewed Original ResearchCitationsAltmetricConceptsCD8+ T cellsAnti-tumor immunityRegulatory T cellsT cellsSubpopulation of CD8+ T cellsCytotoxic CD8+ T cellsHuman CD8+ T cellsTumor antigen-specific CD8Impaired anti-tumor immunityTumor antigen-specificPoor overall survivalTumor rejectionKIR expressionOverall survivalTumor antigensImmune evasionCellular mediatorsHuman cancersCD8MelanomaTumorTranscriptional programsFunctional heterogeneityImmunityPatients
2023
Prior cycles of anti-CD20 antibodies affect antibody responses after repeated SARS-CoV-2 mRNA vaccination
Asashima H, Kim D, Wang K, Lele N, Buitrago-Pocasangre N, Lutz R, Cruz I, Raddassi K, Ruff W, Racke M, Wilson J, Givens T, Grifoni A, Weiskopf D, Sette A, Kleinstein S, Montgomery R, Shaw A, Li F, Fan R, Hafler D, Tomayko M, Longbrake E. Prior cycles of anti-CD20 antibodies affect antibody responses after repeated SARS-CoV-2 mRNA vaccination. JCI Insight 2023, 8: e168102. PMID: 37606046, PMCID: PMC10543713, DOI: 10.1172/jci.insight.168102.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSARS-CoV-2 mRNA vaccinationB-cell-depleted patientsB-cell depletionAntibody responseMRNA vaccinationThird doseCell depletionT cellsClaude D. Pepper Older Americans Independence CenterB cellsNational Multiple Sclerosis SocietyAnti-CD20 antibodySpike-specific antibodiesMultiple Sclerosis SocietyLow cumulative exposureLogistic regression modelsImportant clinical needCD20 therapyCD20 treatmentMost patientsThird vaccineSerologic responseVaccine dosesMRNA vaccinesVaccination strategiesMicrofluidic Immuno-Serolomic Assay Reveals Systems Level Association with COVID-19 Pathology and Vaccine Protection
Kim D, Biancon G, Bai Z, VanOudenhove J, Liu Y, Kothari S, Gowda L, Kwan JM, Buitrago-Pocasangre NC, Lele N, Asashima H, Racke MK, Wilson JE, Givens TS, Tomayko MM, Schulz WL, Longbrake EE, Hafler DA, Halene S, Fan R. Microfluidic Immuno-Serolomic Assay Reveals Systems Level Association with COVID-19 Pathology and Vaccine Protection. Small Methods. 2023 Oct;7(10):e2300594. doi: 10.1002/smtd.202300594. Epub 2023 Jun 13. PMID: 37312418; PMCID: PMC10592458.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
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Activities
activity Aligning Science Across Parkinson’s (ASAP)
03/06/2023 - PresentProfessional OrganizationsMember
Get In Touch
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Lab Number
Mailing Address
Hafler Lab
300 GEORGE ST
NEW HAVEN, Connecticut 06510
United States
Locations
300 George Street
Lab
Ste 353
New Haven, CT 06511
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