Morgan Goheen, MD, PhD
InstructorAbout
Research
Publications
2024
Two Mosquito Salivary Antigens Demonstrate Promise as Biomarkers of Recent Exposure to Plasmodium falciparum–Infected Mosquito Bites
Lapidus S, Goheen M, Sy M, Deme A, Ndiaye I, Diedhiou Y, Mbaye A, Hagadorn K, Sene S, Pouye M, Thiam L, Ba A, Guerra N, Mbengue A, Raduwan H, Gagnon J, Vigan-Womas I, Parikh S, Ko A, Ndiaye D, Fikrig E, Chuang Y, Bei A. Two Mosquito Salivary Antigens Demonstrate Promise as Biomarkers of Recent Exposure to Plasmodium falciparum–Infected Mosquito Bites. The Journal Of Infectious Diseases 2024, 231: e570-e581. PMID: 39475423, PMCID: PMC11911913, DOI: 10.1093/infdis/jiae525.Peer-Reviewed Original ResearchModerate transmission areasMosquito salivary proteinsModerately endemic areaAntibody responseMosquito exposureTransmission seasonP. falciparum infectionMalaria transmission seasonMalaria transmission intensityExposure to infectious mosquitoesMosquito bitesEntomological inoculation rateEndemic areasHuman immune responseInfected mosquito bitesTransmission areasDecline 3 monthsNo antibody responseExposure to infected mosquitoesP. falciparumControl cohortExposure to mosquitoesBead-based assayImmune responseSalivary proteinsSexually Transmitted Infections in People with Human Immunodeficiency Virus
Tuan J, Goheen M, Trebelcock W, Dunne D. Sexually Transmitted Infections in People with Human Immunodeficiency Virus. Infectious Disease Clinics Of North America 2024, 38: 559-579. PMID: 38871569, PMCID: PMC12124183, DOI: 10.1016/j.idc.2024.04.007.Peer-Reviewed Original ResearchConceptsSexually transmitted infectionsHuman immunodeficiency virusImmunodeficiency virusBurden of sexually transmitted infectionsNucleic acid amplification testsSpread of sexually transmitted infectionsTreatment of patientsDiagnosis of syphilisSexual history takingAmplification testsReduce morbidityPostexposure prophylaxisHistory takingScreening practicesMyriad symptomsProvider awarenessPWHPatientsInfectionVirusProphylaxisMorbidityHIVSyphilisDiagnosis
2023
Growing Up COVID
Goheen M. Growing Up COVID. Clinical Infectious Diseases 2023, 78: 496-498. PMID: 37791956, PMCID: PMC11487099, DOI: 10.1093/cid/ciad563.Peer-Reviewed Original Research
2022
Hepcidin-guided screen-and-treat interventions for young children with iron-deficiency anaemia in The Gambia: an individually randomised, three-arm, double-blind, controlled, proof-of-concept, non-inferiority trial
Wegmüller R, Bah A, Kendall L, Goheen M, Sanyang S, Danso E, Sise E, Jallow A, Verhoef H, Jallow M, Wathuo M, Armitage A, Drakesmith H, Pasricha S, Cross J, Cerami C, Prentice A. Hepcidin-guided screen-and-treat interventions for young children with iron-deficiency anaemia in The Gambia: an individually randomised, three-arm, double-blind, controlled, proof-of-concept, non-inferiority trial. The Lancet Global Health 2022, 11: e105-e116. PMID: 36521942, PMCID: PMC9764454, DOI: 10.1016/s2214-109x(22)00449-1.Peer-Reviewed Original ResearchConceptsMultiple micronutrient powdersPlasma hepcidin concentrationsRespiratory tract infectionsAdverse eventsHepcidin concentrationsIron supplementationNon-inferiority marginNon-inferiority trialDouble-blindTract infectionsControl groupIron deficiencyPrimary outcomeWHO standard of careAssociated with serious adverse outcomesLower respiratory tract infectionsUniversal iron supplementationUpper respiratory tract infectionPer-protocol populationIron deficiency anemiaDays of iron supplementationNon-serious adverse eventsGastrointestinal side effectsSerious adverse outcomesHemoglobin concentration
2021
Artemisinin Activity in Red Blood Cells from Anemic Children.
Joof F, Goheen M, Cerami C. Artemisinin Activity in Red Blood Cells from Anemic Children. American Journal Of Tropical Medicine And Hygiene 2021, 104: 271-275. PMID: 33169662, PMCID: PMC7790081, DOI: 10.4269/ajtmh.20-0304.Peer-Reviewed Original ResearchConceptsRed blood cellsArtemisinin activationHost anemiaRing-stage survival assayClasses of antimalarial drugsMalaria-endemic countriesArtemisinin combination therapyArtemisinin-resistant strainsBlood cellsConsequent production of reactive oxygen speciesIron-deficient individualsArtemisinin sensitivityArtemisinin resistanceFalciparum malariaFrontline therapyAssessed in vitroCombination therapyGambian childrenParasite clearancePregnant womenHemoglobin levelsAntimalarial drugsDrug sensitivityProduction of reactive oxygen speciesSurvival assay
2020
Nutritional Frameworks in Malaria
Kim H, Goheen M, Bei A. Nutritional Frameworks in Malaria. Nutrition And Health 2020, 297-324. DOI: 10.1007/978-3-030-56913-6_11.Peer-Reviewed Original ResearchCause of malariaCause of deathPublic health interventionsSpread of malariaPregnant womenEndemic areasSingle diseaseNutritional statusHealth interventionsMalariaMalnutritionSurveillance methodsStandardized approachCauseSaharan AfricaInterventionSystems biology approachLarge-scale researchNutritional frameworkDiseaseBiomarkersSeverity
2019
Hepcidin-guided screen-and-treat interventions against iron-deficiency anaemia in pregnancy: a randomised controlled trial in The Gambia
Bah A, Muhammad A, Wegmuller R, Verhoef H, Goheen M, Sanyang S, Danso E, Sise E, Pasricha S, Armitage A, Drakesmith H, Cross J, Moore S, Cerami C, Prentice A. Hepcidin-guided screen-and-treat interventions against iron-deficiency anaemia in pregnancy: a randomised controlled trial in The Gambia. The Lancet Global Health 2019, 7: e1564-e1574. PMID: 31607468, PMCID: PMC7109523, DOI: 10.1016/s2214-109x(19)30393-6.Peer-Reviewed Original ResearchConceptsWHO-recommended regimenScreen-and-treat approachPer-protocol populationIron deficiency anemiaNon-inferiority marginPregnant womenSide effectsPrimary outcomeAmount of hemoglobinIron regulatory hormone hepcidinWeeks of gestationFrequent side effectsDaily iron supplementationStages of gestationNon-inferiority trialCombat iron deficiency anemiaDouble-blindRandomised controlled trialsIron administrationAdverse eventsIron supplementationFollow-upRegimenHormone hepcidinSafety outcomesThe ferroportin Q248H mutation protects from anemia, but not malaria or bacteremia
Muriuki J, Mentzer A, Band G, Gilchrist J, Carstensen T, Lule S, Goheen M, Joof F, Kimita W, Mogire R, Cutland C, Diarra A, Rautanen A, Pomilla C, Gurdasani D, Rockett K, Mturi N, Ndungu F, Scott J, Sirima S, Morovat A, Prentice A, Madhi S, Webb E, Elliott A, Bejon P, Sandhu M, Hill A, Kwiatkowski D, Williams T, Cerami C, Atkinson S. The ferroportin Q248H mutation protects from anemia, but not malaria or bacteremia. Science Advances 2019, 5: eaaw0109. PMID: 31517041, PMCID: PMC6726445, DOI: 10.1126/sciadv.aaw0109.Peer-Reviewed Original ResearchConceptsQ248H mutationMalaria-infected miceAssociated with modest protectionErythrocytes ex vivoFerroportin Q248H mutationAssociated with protectionStudies of limited sizeEvidence of protectionSevere malariaMalaria exposureMalaria parasitesQ248HHemolytic anemiaModest protectionIron deficiencyMalariaHuman studiesAfrican childrenAnemiaBacteremiaFerroportinMature erythrocytesMutationsIncreased fatalityIron acquisition
2017
Host iron status and erythropoietic response to iron supplementation determines susceptibility to the RBC stage of falciparum malaria during pregnancy
Goheen M, Bah A, Wegmüller R, Verhoef H, Darboe B, Danso E, Prentice A, Cerami C. Host iron status and erythropoietic response to iron supplementation determines susceptibility to the RBC stage of falciparum malaria during pregnancy. Scientific Reports 2017, 7: 17674. PMID: 29247172, PMCID: PMC5732269, DOI: 10.1038/s41598-017-16896-z.Peer-Reviewed Original ResearchConceptsIron supplementationPregnant womenGrowth in vitroCD71-positive reticulocytesMalaria-endemic areasAnaemic pregnant womenResponse to iron supplementationIncreased malaria riskHost iron statusObservational cohort studyWorld Health Organization recommendationsPathogenesis in vitroFalciparum malariaMalaria preventionErythroid recoveryMalaria riskIron statusCohort studyElevated erythropoiesisMalariaEndemic areasOrganization recommendationsWomenRBCSub-Saharan AfricaThe role of the red blood cell in host defence against falciparum malaria: an expanding repertoire of evolutionary alterations
Goheen M, Campino S, Cerami C. The role of the red blood cell in host defence against falciparum malaria: an expanding repertoire of evolutionary alterations. British Journal Of Haematology 2017, 179: 543-556. PMID: 28832963, PMCID: PMC5922454, DOI: 10.1111/bjh.14886.Peer-Reviewed Original ResearchConceptsRed blood cellsGenome-wide association studiesRed blood cell cytoskeletonMalaria pathogenesisHuman genomeAssociation studiesBlood cellsInnate resistance to malariaResistance to malariaEvolutionary alterationsHuman hostHost defenceIntracellular enzymesFalciparum malariaMalaria parasitesRed blood cell morphologyPolymorphismSurface markersMalariaProteinHostGenomePathogenesisCellsCytoskeleton