Mireille Serlie, MD, PhD

My laboratory uses an integrative human physiology approach that combines metabolic phenotyping, stable-isotope tracer studies, molecular analyses of insulin sensitive tissues, and advanced neuroimaging to understand how obesity alters nutrient sensing, insulin action, and the regulation of energy and glucose metabolism.

A major focus of our work is understanding how the brain responds to nutrients and how dopamine signaling influences eating behavior and systemic glucose metabolism. We are currently studying how dynamic dopamine responses to food intake differ in obesity and how these responses relate to metabolic and hormonal signals.

In parallel, we investigate tissue-specific insulin resistance and the molecular mechanisms that regulate insulin action in liver, adipose tissue, and skeletal muscle.

Our work brings together human metabolism, neuroscience, imaging, and molecular biology, with the goal of identifying mechanisms that can ultimately be targeted to improve metabolic health.