Min Wang, PhD
Senior Research Scientist in NeuroscienceCards
About
Research
Publications
2026
Inflammatory mechanisms underlying early Alzheimer’s disease pathology: evidence from the aging rhesus macaque brain
Datta D, Wang M, Arnsten A. Inflammatory mechanisms underlying early Alzheimer’s disease pathology: evidence from the aging rhesus macaque brain. Frontiers In Cellular Neuroscience 2026, 20: 1750092. PMID: 41767744, PMCID: PMC12935894, DOI: 10.3389/fncel.2026.1750092.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAlzheimer's diseaseAssociation cortexSoluble formDisease pathologyTau hyperphosphorylationAmyloid-bSporadic ADHyperphosphorylated tauAlzheimer's disease pathologyPTau pathologyInflammatory signalingPrimate association cortexSynapse lossAmyloid pathologyEarly-stage pathologyCognitive deficitsSporadic formsCortical networksCognitive declineCalcium signalingRhesus macaque brainHuman brain tissueTauAutophagic degenerationAged macaques
2025
Kynurenic acid signaling expands in human and nonhuman primates and impairs dorsolateral prefrontal cortical cognition that is key to mental illness
Yang S, Datta D, Krienen F, Woo E, May A, Anderson G, Galvin V, Gonzalez-Burgos G, Lewis D, Ling E, McCarroll S, Arnsten A, Wang M. Kynurenic acid signaling expands in human and nonhuman primates and impairs dorsolateral prefrontal cortical cognition that is key to mental illness. Molecular Psychiatry 2025, 31: 1190-1200. PMID: 41413200, PMCID: PMC12929064, DOI: 10.1038/s41380-025-03425-y.Peer-Reviewed Original ResearchHigher cognitive deficitsCognitive deficitsPrimate dlPFCKAT IIKynurenic acidNeuronal firingDorsolateral prefrontal cortexAged macaquesPlasma kynurenine/tryptophan ratioSystemic administration of agentsSystemic administrationHuman dlPFCPrefrontal cortexWorking memoryDlPFC neuronsAged monkeysKynurenic acid productionCognitive performanceDLPFCCognitive functionMental illnessKynurenine/tryptophan ratioNonhuman primatesDeficitsApplication of kynurenic acidPrefrontal cortical NR2B-containing NMDA receptors are essential for spatial working memory performance
Peng J, Wang G, Han Y, Qu L, Wang M, Arnsten A, Cai J, Li B. Prefrontal cortical NR2B-containing NMDA receptors are essential for spatial working memory performance. Translational Psychiatry 2025, 15: 357. PMID: 41052993, PMCID: PMC12501000, DOI: 10.1038/s41398-025-03595-x.Peer-Reviewed Original ResearchConceptsNR2B-containing NMDA receptorsPrefrontal cortexSpatial working memoryWorking memoryN-methyl-D-aspartateNMDA receptorsNon-human primatesPattern discriminationWorking memory performanceSubunit of N-methyl-D-aspartateN-methyl-D-aspartate receptorsGluR2 subunitVisual cortexLayer III pyramidal cellsMemory performanceNeuropharmacological evidenceNR2B-containing receptorsCell firingExpression ratioCortexMemoryNR2BHippocampusPost-synapsePyramidal cellsDysregulated calcium signaling in the aged primate association cortices: vulnerability to Alzheimer’s disease neuropathology
Arnsten A, Perone I, Wang M, Yang S, Uchendu S, Bolat D, Datta D. Dysregulated calcium signaling in the aged primate association cortices: vulnerability to Alzheimer’s disease neuropathology. Frontiers In Aging Neuroscience 2025, 17: 1610350. PMID: 40735190, PMCID: PMC12303958, DOI: 10.3389/fnagi.2025.1610350.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsTau pathologyEtiology of sporadic ADCalcium signalingAlzheimer's diseaseCalpain-2Calcium dysregulationDisease neuropathologyRegulation of calcium signalingAutophagic degenerationAPOE-e4 carriersOnset formAlzheimer's disease neuropathologyTau hyperphosphorylationActivation of calpain-2Sporadic ADAD pathologySynapse lossAmyloid pathologyCalpain-2 inhibitorDysregulated calciumTauAssociation cortexHigh-resolution nanoscale imagingTherapeutic targetAged macaques
2024
Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders
Datta D, Yang S, Joyce M, Woo E, McCarroll S, Gonzalez-Burgos G, Perone I, Uchendu S, Ling E, Goldman M, Berretta S, Murray J, Morozov Y, Arellano J, Duque A, Rakic P, O’Dell R, van Dyck C, Lewis D, Wang M, Krienen F, Arnsten A. Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders. JAMA Psychiatry 2024, 81: 870-881. PMID: 38776078, PMCID: PMC11112502, DOI: 10.1001/jamapsychiatry.2024.1112.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexPrefrontal cortexLayer III pyramidal cellsWorking memoryCognitive disordersNeuronal firingPrimate dorsolateral prefrontal cortexPyramidal cellsSpatial working memoryWorking memory performanceRisk of mental disordersCalcium-related proteinsReduced neuronal firingL-type calcium channel Cav1.2GluN2B-NMDA receptorsL-type calcium channel activityPrefrontal neuronsL-type calcium channel blockerMemory performanceL-type calcium channelsMental disordersRisk of cognitive disordersCognitive behaviorProtein expressionAssociated with increased riskβ1-adrenoceptor expression on GABAergic interneurons in primate dorsolateral prefrontal cortex: potential role in stress-induced cognitive dysfunction
Joyce M, Yang S, Morin K, Duque A, Arellano J, Datta D, Wang M, Arnsten A. β1-adrenoceptor expression on GABAergic interneurons in primate dorsolateral prefrontal cortex: potential role in stress-induced cognitive dysfunction. Neurobiology Of Stress 2024, 30: 100628. PMID: 38550854, PMCID: PMC10973161, DOI: 10.1016/j.ynstr.2024.100628.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsDorsolateral prefrontal cortexPrefrontal cortexStress-induced cognitive dysfunctionTreat stress-related disordersPrimate dorsolateral prefrontal cortexImpaired working memoryWorking Memory DeficitsWorking Memory TaskCalcium-binding proteins calbindinStress-related disordersClasses of inhibitory neuronsLevels of norepinephrineFast-spikingMemory taskDopamine releaseWorking memoryMemory deficitsInhibitory neuronsCognitive dysfunctionPV interneuronsGABAergic interneuronsDLPFCBehavior analysisCortexPyramidal cellsDynamic Network Connectivity: from monkeys to humans
Arnsten A, Wang M, D’Esposito M. Dynamic Network Connectivity: from monkeys to humans. Frontiers In Human Neuroscience 2024, 18: 1353043. PMID: 38384333, PMCID: PMC10879414, DOI: 10.3389/fnhum.2024.1353043.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsDynamic network connectivityFunctional MRIFunctional connectivityHuman brain imaging researchDorsolateral prefrontal cortexNMDA receptor neurotransmissionBrain imaging researchHuman fMRI studiesPrefrontal cortexReceptor neurotransmissionWorking memoryFMRI studyBrain regionsPersistent neuronal firingNeuromodulator acetylcholineCognitive disordersCortical regionsDLPFCPost-synaptic densityArousal stateStrength of synaptic connectionsNeuronal firingCognitive statesImaging researchDendritic spines
2023
Scientific Rationale for the Treatment of Cognitive Deficits from Long COVID
Zadeh A, Arnsten A, Wang M. Scientific Rationale for the Treatment of Cognitive Deficits from Long COVID. Neurology International 2023, 15: 725-742. PMID: 37368329, PMCID: PMC10303664, DOI: 10.3390/neurolint15020045.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsLong COVIDGlutamate carboxypeptidase IIKynurenic acidNicotinic alpha 7 receptorCognitive deficitsProduction of KYNACOVID-19 infectionDorsolateral prefrontal cortexAgonist guanfacineNeuronal firingCognitive symptomsAcetyl cysteineCognitive functionPrefrontal cortexScientific rationaleCarboxypeptidase IIPFC functionCOVIDDeficitsReceptorsTreatmentExecutive functioningNMDAGuanfacineNeurotransmission
2017
mGluR2/3 mechanisms in primate dorsolateral prefrontal cortex: evidence for both presynaptic and postsynaptic actions
Jin L, Wang M, Yang S, Yang Y, Galvin V, Lightbourne T, Ottenheimer D, Zhong Q, Stein J, Raja A, Paspalas C, Arnsten A. mGluR2/3 mechanisms in primate dorsolateral prefrontal cortex: evidence for both presynaptic and postsynaptic actions. Molecular Psychiatry 2017, 22: 1511-1511. DOI: 10.1038/mp.2017.206.Peer-Reviewed Original Research
2013
Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex
Yang Y, Paspalas CD, Jin LE, Picciotto MR, Arnsten AF, Wang M. Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 12078-12083. PMID: 23818597, PMCID: PMC3718126, DOI: 10.1073/pnas.1307849110.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAconitinealpha7 Nicotinic Acetylcholine ReceptorAnalysis of VarianceAnimalsBridged Bicyclo Compounds, HeterocyclicCholinergic AgonistsCholinergic AntagonistsCognitionFemaleIontophoresisMacaca mulattaMaleMecamylamineMicroscopy, ImmunoelectronN-MethylaspartatePhenolsPiperidinesPrefrontal CortexQuinuclidinesReceptors, NicotinicSpatial BehaviorSynapsesVisual PerceptionConceptsDorsolateral prefrontal cortexΑ7 nAChRsPrefrontal cortexΑ7 nicotinic acetylcholine receptorGlutamatergic NMDA receptorsCognitive circuitsNicotinic α7 receptorsPrimary visual cortexNMDA receptor actionGenetic insultsNicotinic acetylcholine receptorsDlPFC circuitsPrimate dlPFCACh depletionNMDA actionNMDA receptorsPyramidal cellsΑ7 receptorsNeuronal firingNAChR blockadeAcetylcholine receptorsVisual cortexPersistent firingCognitive functionLow-dose stimulation
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