Michail Kokkorakis, MD, PhD
Postdoctoral FellowAbout
Research
Publications
2026
Visceral adiposity and cardiovascular risk in the era of cardiovascular-kidney-metabolic syndrome
Kokkorakis M, Oikonomou E. Visceral adiposity and cardiovascular risk in the era of cardiovascular-kidney-metabolic syndrome. American Journal Of Preventive Cardiology 2026, 101558. DOI: 10.1016/j.ajpc.2026.101558.Peer-Reviewed Original ResearchLong-term Risk of Prediabetes and Type 2 Diabetes Following SARS-CoV-2 Infection: A Nationwide Cohort Study
Anagnostakis F, Kokkorakis M. Long-term Risk of Prediabetes and Type 2 Diabetes Following SARS-CoV-2 Infection: A Nationwide Cohort Study. Endocrine Practice 2026 PMID: 41690583, DOI: 10.1016/j.eprac.2026.02.003.Peer-Reviewed Original ResearchSARS-CoV-2 infectionType 2 diabetesLong-term riskSARS-CoV-2Cohort studyPopulation-based cohort studyKaplan-Meier analysisIncidence of prediabetesCox proportional hazards modelsNationwide cohort studyRisk of prediabetesNegative COVID-19 testTime-to-event analysisDiagnosis of prediabetesProportional hazards modelLong-term associationPropensity score matchingPersistent elevationSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2COVID-19 testingHigher incidencePrediabetesSyndrome coronavirus 2Association of glucagon-like peptide-1 receptor agonist use with anxiety disorders, depression, self-harm, and suicidality: a large cohort study
Anagnostakis F, Kokkorakis M, Anastasiou G, Nagarajan S, Mantzoros C. Association of glucagon-like peptide-1 receptor agonist use with anxiety disorders, depression, self-harm, and suicidality: a large cohort study. Diabetes Research And Clinical Practice 2026, 233: 113104. PMID: 41592697, DOI: 10.1016/j.diabres.2026.113104.Peer-Reviewed Original ResearchConceptsAnxiety disordersGLP-1 RAsSelf-harmHigher risk of anxiety disordersIncidence of anxiety disordersRisk of anxiety disordersGLP-1High riskLower suicide riskAnxiety disorder riskHigher risk of depressionGlucagon-like peptide-1 receptor agonist useCohort studyRisk of depressionSuicidal ideationSuicide riskFirst-line treatmentDisorder riskPropensity-matched cohortDepressionSuicideType 2 diabetesAgonist useDisordersTreatment initiation
2025
Comparative effectiveness of sodium‐glucose cotransporter‐2 inhibitors and glucagon‐like peptide‐1 receptor agonists for incident dementia: A retrospective multicohort study
Anagnostakis F, Kokkorakis M, Nagarajan S, Anastasiou G, Mantzoros C. Comparative effectiveness of sodium‐glucose cotransporter‐2 inhibitors and glucagon‐like peptide‐1 receptor agonists for incident dementia: A retrospective multicohort study. Diabetes Obesity And Metabolism 2025, 28: 1443-1452. PMID: 41309383, PMCID: PMC12803637, DOI: 10.1111/dom.70336.Peer-Reviewed Original ResearchIncident dementiaRisk of incident dementiaAlzheimer's dementiaAll-cause dementiaRisk of dementiaElectronic health recordsCox proportional hazards modelsSGLT2 inhibitor usersHealth recordsProportional hazards modelType 2 diabetes mellitusComparative effectivenessRA usersCohort studyDementiaSecondary outcomesConfounding variablesPrimary outcomeReal-world evidenceHazards modelMulticohort studySubgroup analysisScore-matched cohortCognitive outcomesSodium-glucose cotransporter-2 inhibitorsImpact of cardiometabolic conditions on the progression from mild cognitive impairment to dementia: A large cohort study
Anagnostakis F, Kokkorakis M, Asvestis C, Papadimopoulos I, Nagarajan S, Talbot K, Li L, Chen Y, Nasrallah I, Wen J, Davatzikos C. Impact of cardiometabolic conditions on the progression from mild cognitive impairment to dementia: A large cohort study. Alzheimer's & Dementia 2025, 21: e70692. PMID: 40951936, PMCID: PMC12434604, DOI: 10.1002/alz.70692.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentType 2 diabetesCardiometabolic conditionsVascular dementiaMild cognitive impairment to dementiaAll-cause dementiaAD dementia riskAssociated with Alzheimer's diseaseHigh riskElectronic health recordsProgression of mild cognitive impairmentCognitive impairmentAll-cause riskDementia riskHealth recordsCardiometabolic factorsCohort studyDementiaGreater riskTime-to-event outcomesPropensity score matchingFollow-upRiskCohortAlzheimer's diseaseRadiomic and proteomic signatures of body mass index on brain ageing and Alzheimer's-like patterns of brain atrophy
Anagnostakis F, Kokkorakis M, Walker K, Skampardoni I, Wen J, Erus G, Tosun D, Tassopoulou V, Cui Y, Govindarajan S, Srinivasan D, Melhem R, Mamourian E, Shou H, Nasrallah I, Mantzoros C, Davatzikos C. Radiomic and proteomic signatures of body mass index on brain ageing and Alzheimer's-like patterns of brain atrophy. EBioMedicine 2025, 116: 105763. PMID: 40435724, PMCID: PMC12159507, DOI: 10.1016/j.ebiom.2025.105763.Peer-Reviewed Original ResearchConceptsBrain agingAD-like atrophyBody mass indexBrain atrophyNormal weightImpact of obesityPatterns of brain atrophyIntramural Research ProgramOverweight groupBrain age indexAlzheimer's diseaseMass indexSex-specific mechanismsImpact of high body mass indexBody mass index categoriesNeuroimaging markersSex differencesCognitive impairmentHigher Body Mass IndexNational Institute on Aging Intramural Research ProgramProteomic signatureBrainNational Institute on AgingBMI changeInstitute on Aging
2024
Simplifying coronary artery disease risk stratification: development and validation of a questionnaire-based alternative comparable to clinical risk tools
Kokkorakis M, Folkertsma P, Anagnostakis F, Sirotin N, Agarwal M, Shantouf R, Henning R, Pijl H, Wolffenbuttel B, Bax J, Atsma D, Forte J, Mantzoros C, van Dam S. Simplifying coronary artery disease risk stratification: development and validation of a questionnaire-based alternative comparable to clinical risk tools. EBioMedicine 2024, 111: 105518. PMID: 39724785, PMCID: PMC11732493, DOI: 10.1016/j.ebiom.2024.105518.Peer-Reviewed Original ResearchConceptsQuestionnaire variablesClinical prediction modelAmerican College of Cardiology/American Heart Association Pooled Cohort EquationsCoronary heart disease risk scoreFramingham Coronary Heart Disease Risk ScoreAmerican CollegeDisease risk scoreIdentification of high-risk individualsPooled Cohort EquationsCoronary artery diseaseRisk prediction toolsPopulation-wide screeningExternal validation populationHigh-risk individualsHealth professionalsUK BiobankCohort EquationsResource-limited settingsArtery diseaseLifelines cohortCox proportional hazardsQuestionnaire-based evaluationRisk chartsPhysical measurementsRisk toolEmerging pharmacotherapies for obesity: A systematic review
Kokkorakis M, Chakhtoura M, Rhayem C, Al Rifai J, Ghezzawi M, Valenzuela-Vallejo L, Mantzoros C. Emerging pharmacotherapies for obesity: A systematic review. Pharmacological Reviews 2024, 77: 100002. PMID: 39952695, DOI: 10.1124/pharmrev.123.001045.Peer-Reviewed Original ResearchConceptsPhase 2 trialPhase 3 trialGlucagon-like peptide-1Systematic reviewLong-term follow-up dataPhase 3 clinical trialsWeight loss pharmacotherapyObesity-related complicationsIncretin-based therapiesExcess body weightIncretin analogsFollow-up dataObesity pharmacotherapyAntiobesity pharmacotherapyOral semaglutideClinician's armamentariumMechanism of actionSuboptimal efficacyAntiobesity drugsWeight maintenanceBridge the care gapObesity managementPeptide-1Weight managementObesityThe impact of weight loss on fat-free mass, muscle, bone and hematopoiesis health: Implications for emerging pharmacotherapies aiming at fat reduction and lean mass preservation
Stefanakis K, Kokkorakis M, Mantzoros C. The impact of weight loss on fat-free mass, muscle, bone and hematopoiesis health: Implications for emerging pharmacotherapies aiming at fat reduction and lean mass preservation. Metabolism 2024, 161: 156057. PMID: 39481534, DOI: 10.1016/j.metabol.2024.156057.Peer-Reviewed Original ResearchConceptsFat-free massReceptor agonistsBariatric surgeryWeight lossMetabolic healthImpact of weight lossFat lossAnti-obesity medicationsRisk of sarcopeniaIncretin receptor agonistsSkeletal muscle massLean mass preservationTreatment of obesityWell-designed studiesLoss of muscleState of negative energy balanceSarcopenic obesityBone lossBone massLean massMuscle lossAdvanced ageTherapeutic approachesLong-term benefitsBody compositionGDF-15 improves the predictive capacity of steatotic liver disease non-invasive tests for incident morbidity and mortality risk for cardio-renal-metabolic diseases and malignancies
Kokkorakis M, Folkertsma P, Forte J, Wolffenbuttel B, van Dam S, Mantzoros C. GDF-15 improves the predictive capacity of steatotic liver disease non-invasive tests for incident morbidity and mortality risk for cardio-renal-metabolic diseases and malignancies. Metabolism 2024, 163: 156047. PMID: 39396641, DOI: 10.1016/j.metabol.2024.156047.Peer-Reviewed Original ResearchConceptsAspartate aminotransferase to platelet ratio indexGDF-15Lipid accumulation productFatty liver indexNoninvasive toolHepatic steatosis indexAminotransferase to platelet ratio indexIncident casesFibrosis 4 indexGrowth differentiation factor 15Cause-specificMedian Follow-UpPlatelet ratio indexAbstractText Label="Background &Type 2 diabetes mellitusDifferentiation factor 15Web-based calculator toolNon-invasive testsUK Biobank participantsCases of adverse outcomesFIB-4Cumulative incidencePrognostic performanceAbstractText Label="ConclusionsC-index
Academic Achievements & Community Involvement
News
News
- April 27, 2026
From AI Flashcards to XR Anatomy: YSM Teams Build Prototypes to Transform Medical Education
- March 26, 2026
Fellow Focus in Four: Michail Kokkorakis, MD, PhD, Section of Digestive Diseases
- December 03, 2025
Welcome New Faculty, Staff, Postdocs, and Postgrads in the Yale Department of Internal Medicine (December 2025)
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Mailing Address
Digestive Diseases
333 Cedar St, 1080 LMP
New Haven, Connecticut 06520-8019
United States
Locations
The Anlyan Center
Lab
300 Cedar Street, Fl 2, Rm S241
New Haven, CT 06519