Matthew Alsaloum, PhD
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Departments & Organizations
Education & Training
- PhD
- Yale School of Medicine, Interdepartmental Neuroscience Program (2021)
- BS
- Stony Brook University, Biology (Neuroscience) (2015)
Research
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Overview
Medical Research Interests
Pain
ORCID
0000-0002-9832-0138
Research at a Glance
Yale Co-Authors
Frequent collaborators of Matthew Alsaloum's published research.
Publications Timeline
A big-picture view of Matthew Alsaloum's research output by year.
Research Interests
Research topics Matthew Alsaloum is interested in exploring.
Shujun Liu
Stephen Waxman, MD, PhD
Peng Zhao, PhD
Sulayman Dib-Hajj, PhD
Brian Tanaka, PhD
Nivedita Sarveswaran
Former YSM
14Publications
583Citations
Publications
2025
Targeting sodium channels — challenges for acute pain and the leap to chronic pain
Alsaloum M, Vasylyev D, Waxman S. Targeting sodium channels — challenges for acute pain and the leap to chronic pain. Nature Reviews Neurology 2025, 21: 567-576. PMID: 40817289, DOI: 10.1038/s41582-025-01127-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricVoltage-gated sodium channels in excitable cells as drug targets
Alsaloum M, Dib-Hajj S, Page D, Ruben P, Krainer A, Waxman S. Voltage-gated sodium channels in excitable cells as drug targets. Nature Reviews Drug Discovery 2025, 24: 358-378. PMID: 39901031, PMCID: PMC12379884, DOI: 10.1038/s41573-024-01108-x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
2022
Depolarizing NaV and Hyperpolarizing KV Channels Are Co-Trafficked in Sensory Neurons
Higerd-Rusli GP, Alsaloum M, Tyagi S, Sarveswaran N, Estacion M, Akin EJ, Dib-Hajj FB, Liu S, Sosniak D, Zhao P, Dib-Hajj SD, Waxman SG. Depolarizing NaV and Hyperpolarizing KV Channels Are Co-Trafficked in Sensory Neurons. Journal Of Neuroscience 2022, 42: 4794-4811. PMID: 35589395, PMCID: PMC9188389, DOI: 10.1523/jneurosci.0058-22.2022.Peer-Reviewed Original ResearchCitationsAltmetricStem cell-derived sensory neurons modelling inherited erythromelalgia: normalization of excitability
Alsaloum M, Labau JIR, Liu S, Effraim P, Waxman SG. Stem cell-derived sensory neurons modelling inherited erythromelalgia: normalization of excitability. Brain 2022, 146: 359-371. PMID: 35088838, PMCID: PMC10060693, DOI: 10.1093/brain/awac031.Peer-Reviewed Original ResearchCitationsAltmetricEvaluation of the Content of Ophthalmology Fellowship Program Web sites
Alsaloum P, Alsaloum M, Kim T, Zheng D, Valentim C, Muste J, Goshe J, Singh R. Evaluation of the Content of Ophthalmology Fellowship Program Web sites. Journal Of Academic Ophthalmology 2022, 14: e127-e132. PMID: 37388469, PMCID: PMC9928003, DOI: 10.1055/s-0042-1747673.Peer-Reviewed Original ResearchCitationsAltmetric
2021
Lacosamide Inhibition of NaV1.7 Channels Depends on its Interaction With the Voltage Sensor Domain and the Channel Pore
Labau JIR, Alsaloum M, Estacion M, Tanaka B, Dib-Hajj FB, Lauria G, Smeets HJM, Faber CG, Dib-Hajj S, Waxman SG. Lacosamide Inhibition of NaV1.7 Channels Depends on its Interaction With the Voltage Sensor Domain and the Channel Pore. Frontiers In Pharmacology 2021, 12: 791740. PMID: 34992539, PMCID: PMC8724789, DOI: 10.3389/fphar.2021.791740.Peer-Reviewed Original ResearchCitationsAltmetricContributions of NaV1.8 and NaV1.9 to excitability in human induced pluripotent stem-cell derived somatosensory neurons
Alsaloum M, Labau JIR, Liu S, Estacion M, Zhao P, Dib-Hajj F, Waxman SG. Contributions of NaV1.8 and NaV1.9 to excitability in human induced pluripotent stem-cell derived somatosensory neurons. Scientific Reports 2021, 11: 24283. PMID: 34930944, PMCID: PMC8688473, DOI: 10.1038/s41598-021-03608-x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsAction PotentialsAutopsyCell DifferentiationElectrophysiologyHumansImmunohistochemistryInduced Pluripotent Stem CellsMembrane PotentialsMutationNAV1.8 Voltage-Gated Sodium ChannelNAV1.9 Voltage-Gated Sodium ChannelNeuronsNeurosciencesPainPatch-Clamp TechniquesProtein IsoformsSensory Receptor CellsSomatosensory CortexiPSCs and DRGs: stepping stones to new pain therapies
Alsaloum M, Waxman SG. iPSCs and DRGs: stepping stones to new pain therapies. Trends In Molecular Medicine 2021, 28: 110-122. PMID: 34933815, PMCID: PMC8810720, DOI: 10.1016/j.molmed.2021.11.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricA novel gain-of-function sodium channel β2 subunit mutation in idiopathic small fiber neuropathy
Alsaloum M, Labau JIR, Sosniak D, Zhao P, Almomani R, Gerrits M, Hoeijmakers JGJ, Lauria G, Faber CG, Waxman SG, Dib-Hajj S. A novel gain-of-function sodium channel β2 subunit mutation in idiopathic small fiber neuropathy. Journal Of Neurophysiology 2021, 126: 827-839. PMID: 34320850, PMCID: PMC8461825, DOI: 10.1152/jn.00184.2021.Peer-Reviewed Original ResearchCitationsAltmetricPaclitaxel increases axonal localization and vesicular trafficking of Nav1.7
Akin EJ, Alsaloum M, Higerd GP, Liu S, Zhao P, Dib-Hajj FB, Waxman SG, Dib-Hajj SD. Paclitaxel increases axonal localization and vesicular trafficking of Nav1.7. Brain 2021, 144: 1727-1737. PMID: 33734317, PMCID: PMC8320304, DOI: 10.1093/brain/awab113.Peer-Reviewed Original ResearchCitationsAltmetric