Mark Perazella, MD
Professor Emeritus of MedicineDownloadHi-Res Photo
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Appointments
Nephrology
Primary
Additional Titles
Director, Acute Dialysis Unit
Medical Director, Yale Physician Associate Program
Medical Director, Yale PA Online Program
Contact Info
Appointments
Nephrology
Primary
Additional Titles
Director, Acute Dialysis Unit
Medical Director, Yale Physician Associate Program
Medical Director, Yale PA Online Program
Contact Info
Appointments
Nephrology
Primary
Additional Titles
Director, Acute Dialysis Unit
Medical Director, Yale Physician Associate Program
Medical Director, Yale PA Online Program
Contact Info
About
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Titles
Professor Emeritus of Medicine
Director, Acute Dialysis Unit; Medical Director, Yale Physician Associate Program; Medical Director, Yale PA Online Program
Appointments
Nephrology
EmeritusPrimary
Other Departments & Organizations
Education & Training
- MD
- New York Medical College (1988)
- Resident
- St. Mary's Hospital
- Fellow
- Yale University School of Medicine
Research
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Overview
Medical Research Interests
Dialysis; Drug-Related Side Effects and Adverse Reactions; Hemodialysis Units, Hospital; HIV; Hypotension; Kidney Diseases; Kidney Failure, Chronic; Nephrogenic Fibrosing Dermopathy; Nephrology
ORCID
0000-0002-6994-2659
Research at a Glance
Yale Co-Authors
Frequent collaborators of Mark Perazella's published research.
Publications Timeline
A big-picture view of Mark Perazella's research output by year.
Research Interests
Research topics Mark Perazella is interested in exploring.
Dennis G Moledina, MD, PhD, FASN
F. Perry Wilson, MD, MSCE
Megan Leila Baker, MD
Randy Luciano, MD, PhD
Ali Abu-Alfa, MD, FASN, FAHA
Lloyd G. Cantley, MD
166Publications
6,411Citations
Kidney Failure, Chronic
Kidney Diseases
Drug-Related Side Effects and Adverse Reactions
Hypotension
Nephrology
Publications
2025
Association of Kidney Biopsy Needle Gauge with Post-Procedure Complications and Biopsy Adequacy.
Staunton M, Garg K, Sadarangani S, Makhijani A, Shelton K, Koval E, Liang C, Shaw M, Kent C, Wilson F, Parikh C, Perazella M, Turner J, Luciano R, Moledina D. Association of Kidney Biopsy Needle Gauge with Post-Procedure Complications and Biopsy Adequacy. Kidney360 2025 PMID: 40402808, DOI: 10.34067/kid.0000000835.Peer-Reviewed Original ResearchAltmetricConceptsOdds of complicationsKidney biopsyOutcomes of blood transfusionBiopsy-related complicationsPropensity score weighting analysisBleeding risk factorsG biopsy needlePost-procedural complicationsScore-weighted analysisHemoglobin dropAngiographic interventionBlood transfusionPost-procedureComplication riskUnivariate analysisAssess safetyComposite outcomeDiagnostic adequacyBiopsy adequacyBiopsyG needleMultivariate analysisComplicationsRisk factorsNeedle gaugeUpdate on Acute Tubulointerstitial Nephritis: Clinical Features, Immunologic Insights, and Diagnostic and Treatment Approaches
Sahutoglu T, Perazella M. Update on Acute Tubulointerstitial Nephritis: Clinical Features, Immunologic Insights, and Diagnostic and Treatment Approaches. Kidney International Reports 2025, 10: 1643-1656. PMID: 40630288, PMCID: PMC12231035, DOI: 10.1016/j.ekir.2025.03.050.Peer-Reviewed Original ResearchCitationsAltmetricConceptsAcute tubulointerstitial nephritisAcute kidney injuryC-reactive proteinAcute kidney diseaseTubulointerstitial nephritisType IV hypersensitivity mechanismKidney diseaseAcute kidney injury etiologyTh2-mediated immune responsesSerum C-reactive proteinTriggered by medicationsTumor necrosis factor (TNF)-aInterleukin (IL)-9Urinary retinol-binding proteinT helper (Th)1T cell polarizationIrreversible kidney damageInflammatory endotypesImprove patient outcomesPrompt diagnosisKidney biopsyT cellsClinical featuresDiagnostic challengeImmune heterogeneityIs Intravenous Contrast-Associated Acute Kidney Injury a Significant Problem and Are Risk Scores Useful?
Perazella M. Is Intravenous Contrast-Associated Acute Kidney Injury a Significant Problem and Are Risk Scores Useful? Kidney360 2025, 6: 9-11. PMID: 40146910, PMCID: PMC11793183, DOI: 10.34067/kid.0000000636.Peer-Reviewed Original Research
2024
Drug-Related Glomerular Phenotypes: A Global Pharmacovigilance Perspective
Baptista A, Macedo A, Marreiros A, Coelho A, Perazella M. Drug-Related Glomerular Phenotypes: A Global Pharmacovigilance Perspective. Journal Of Clinical Medicine 2024, 13: 4869. PMID: 39201010, PMCID: PMC11355908, DOI: 10.3390/jcm13164869.Peer-Reviewed Original ResearchAltmetricConceptsGlomerular disordersAdverse drug reactionsPotential nephrotoxinsNephrotoxic potentialDrug reactionsDisproportion indexNotifications of adverse drug reactionsAssociated with medicationsAssociated with drug useNephrotoxic drugsOver-the-counter drugsNon-nephrotoxicMethods:Physiopathological mechanismsOver-the-counterNephrotoxic rolePrescribed medicationsSpontaneous notificationsVigiBaseDrug useEvaluate medicationsMedicationMedication useNephrotoxinsDrugProton Pump Inhibitors and Kidney Disease: What Gives?
Perazella M. Proton Pump Inhibitors and Kidney Disease: What Gives? Kidney360 2024, 5: 1374-1376. PMID: 39325592, PMCID: PMC11441802, DOI: 10.34067/kid.0000000000000521.Peer-Reviewed Original ResearchAltmetricMeSH KeywordsRemembering Fred S. Wright, M.D. (1937–2023)
Aronson P, Ellison D, Okusa M, Perazella M. Remembering Fred S. Wright, M.D. (1937–2023). Kidney360 2024, 5: 768-770. PMCID: PMC11146636, DOI: 10.34067/kid.0000000000000438.Peer-Reviewed Original ResearchAltmetricIdentification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis
Moledina D, Obeid W, Smith R, Rosales I, Sise M, Moeckel G, Kashgarian M, Kuperman M, Campbell K, Lefferts S, Meliambro K, Bitzer M, Perazella M, Luciano R, Pober J, Cantley L, Colvin R, Wilson F, Parikh C. Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis. Journal Of Clinical Investigation 2024, 134: e180583. PMID: 38488004, PMCID: PMC10940080, DOI: 10.1172/jci180583.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsToxic Nephropathies of the Tubulointerstitium: Core Curriculum 2024
Krishnan N, Moledina D, Perazella M. Toxic Nephropathies of the Tubulointerstitium: Core Curriculum 2024. American Journal Of Kidney Diseases 2024, 83: 659-676. PMID: 38243994, DOI: 10.1053/j.ajkd.2023.09.017.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricConceptsRenal injurySeverity of renal injuryToxic nephropathyTubulointerstitial renal injuryIrreversible renal injuryToxin-induced renal injuryImmune response genesNephrotoxic riskClinical presentationTubulointerstitial injuryRenal functionClinical manifestationsPatient characteristicsTubular secretionGlomerular filtrationComorbid conditionsMetabolic handlingDrug metabolismExcretory pathwayInjuryTransport defectAdverse effectsTubulointerstitiumNephropathyExogenous toxins
2023
Hiding in Plain Sight: Catastrophic Diethylene Glycol Poisoning in Children
Perazella M. Hiding in Plain Sight: Catastrophic Diethylene Glycol Poisoning in Children. Kidney360 2023, 4: 1534-1535. PMID: 37831818, PMCID: PMC10695641, DOI: 10.34067/kid.0000000000000269.Peer-Reviewed Original ResearchCitationsMeSH KeywordsA Patient with an Unusual Cause of AKI and Scrotal Swelling
Gomez D, Perazella M. A Patient with an Unusual Cause of AKI and Scrotal Swelling. Kidney360 2023, 4: 1188-1189. PMID: 37651667, PMCID: PMC10484347, DOI: 10.34067/kid.0000000000000125.Peer-Reviewed Original ResearchAltmetric
Academic Achievements & Community Involvement
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Activities
activity American Society of Nephrology
07/01/2015 - PresentMeeting Planning and ParticipationDirectorDetailsASN Education Co-Director, Board Review Course and Update (BRCU)activity National Kidney Foundation
05/01/2019 - PresentMeeting Planning and ParticipationChairDetailsChair of the NKF Spring Clinical Meeting 2020 (Co-Chair for the meeting in 2019)activity American Society of Nephrology
07/01/2019 - PresentJournal ServiceEditorDetailsDeputy Editor for ASN journal Kidney360activity Italian Society of Nephrology
07/01/2017 - PresentJournal ServiceEditorDetailsCo-Editor-in-Chief for the Journal of Onco-Nephrologyactivity American Society of Nephrology
11/01/2013 - 11/01/2017Meeting Planning and ParticipationChairDetailsChair of the ASN Onco-Nephology Forum
Honors
honor Robert G. Narins Lifetime Achievement Award in Education
07/07/2022National AwardAmerican Society of NephrologyDetailsUnited Stateshonor Donald W. Seldin Distinguished Award
10/02/2020National AwardNational Kidney FoundationDetailsUnited Stateshonor Department of Medicine Faculty Achievement Award in Education
07/01/2005Yale School of Medicine AwardYale University, Department of MedicineDetailsUnited States
News
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News
- December 01, 2023
Dr. Mark Perazella, Internationally Renowned Nephrologist, Retires at Year End
- October 24, 2023
Yale Contributions Shape ASN Kidney Week 2023
- May 25, 2023
YSM PA Online Graduates Celebrated for "Fierce Advocacy"
- May 11, 2023
Discoveries & Impact (May 2023)
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