Maria Kristina Dorotan, MD
she/her/hers
Assistant Professor of NeurologyCards
About
Research
Publications
2025
Cenobamate and pregnancy: A-single level 4 epilepsy center experience
Jimenez A, Toghramadjian I, Okafor C, Hanin A, Zhou X, Dorotan M, Nuthalapati P, Sakya S, Hirsch L, Altalib H, Lazorwitz A, Herlopian A. Cenobamate and pregnancy: A-single level 4 epilepsy center experience. Epilepsy & Behavior 2025, 169: 110440. PMID: 40318387, DOI: 10.1016/j.yebeh.2025.110440.Peer-Reviewed Original ResearchConceptsConcentration-to-dose ratioPost-partum periodUnintended pregnancyContraceptive methodsSingle-center retrospective chart reviewFemales of childbearing ageEarly-term birthPrevent unintended pregnancyAdult female patientsDrug level monitoringMonths of agePre-conceptual counsellingElective terminationSpontaneous miscarriagePregnancy outcomesCongenital malformationsFemale patientsHormonal contraceptionChildbearing ageMedical comorbiditiesCenobamatePregnancyContraceptive usePharmacokinetic profilePatients
2024
Pilot Trial of Perampanel on Peritumoral Hyperexcitability in Newly Diagnosed High-grade Glioma.
Tobochnik S, Regan M, Dorotan M, Reich D, Lapinskas E, Hossain M, Stopka S, Meredith D, Santagata S, Murphy M, Arnaout O, Bi W, Chiocca E, Golby A, Mooney M, Smith T, Ligon K, Wen P, Agar N, Lee J. Pilot Trial of Perampanel on Peritumoral Hyperexcitability in Newly Diagnosed High-grade Glioma. Clinical Cancer Research 2024, 30: 5365-5373. PMID: 39499201, PMCID: PMC11611619, DOI: 10.1158/1078-0432.ccr-24-1849.Peer-Reviewed Original ResearchConceptsHigh-frequency oscillation ratesStandard of careHigh-grade gliomasOverall survivalAMPA receptor antagonist perampanelPrimary outcomeTreated with standard of careStandard of care treatmentGlutamate concentrationPatients treated with perampanelPerampanel-treated patientsPreoperative loading doseHigh-frequency oscillationsKaplan-Meier methodOpen-label trialLevetiracetam-treated patientsPilot trialAdjacent electrode contactsTissue concentrationsAntagonist perampanelMaintenance therapyLoading doseProgressive diseaseAssociated with treatment assignmentGlutamatergic activityPatient-Centered Management of Brain Tumor-Related Epilepsy
Dorotan M, Tobochnik S. Patient-Centered Management of Brain Tumor-Related Epilepsy. Current Neurology And Neuroscience Reports 2024, 24: 413-422. PMID: 39017829, DOI: 10.1007/s11910-024-01360-z.Peer-Reviewed Original ResearchConceptsLikelihood of tumor progressionQuality of lifeRisk of seizure recurrenceTumor-related epilepsyTumor-directed therapyClinical risk factorsPost-operative seizuresCourse of diseaseAnti-seizure medicationsTumor-directed treatmentManagement of seizuresSurvival outcomesTargeted therapyBrain tumor pathologyTumor biologyDiffuse gliomasMultidisciplinary managementSeizure recurrenceTumor pathologyPre-operativelyTumor cellsTumor progressionHyperexcitabilityBrain tumorsHeterogeneous syndromeLong-term neuropsychiatric complications of aneurysmal subarachnoid hemorrhage: a narrative review
Diestro J, Vyas M, Jung Y, Kishibe T, Leochico C, Espiritu A, Dorotan M, Dimal N, Omar A, Sienes A, Saposnik G, Marotta T, Zafar A, Pereira V, Spears J. Long-term neuropsychiatric complications of aneurysmal subarachnoid hemorrhage: a narrative review. Journal Of NeuroInterventional Surgery 2024, 17: 167-174. PMID: 38609175, DOI: 10.1136/jnis-2023-020979.Peer-Reviewed Original ResearchConceptsAneurysmal subarachnoid hemorrhageSurvivors of aneurysmal subarachnoid hemorrhageOutcome of mortalityLong-term neuropsychiatric consequencesSubarachnoid hemorrhageTreated aneurysmsNeuropsychiatric complicationsSexual dysfunctionCognitive dysfunctionRadiological monitoringNeuropsychiatric consequencesNarrative reviewDysfunctionSequalaeCurrent state of the epilepsy drug and device pipeline
Terman S, Kirkpatrick L, Akiyama L, Baajour W, Atilgan D, Dorotan M, Choi H, French J. Current state of the epilepsy drug and device pipeline. Epilepsia 2024, 65: 833-845. PMID: 38345387, PMCID: PMC11018510, DOI: 10.1111/epi.17884.Peer-Reviewed Original ResearchChallenges and directions in epilepsy diagnostics and therapeutics: Proceedings of the 17th Epilepsy Therapies and Diagnostics Development conference
Terman S, Kirkpatrick L, Kerr W, Akiyama L, Baajour W, Atilgan D, Dorotan M, Choi H, French J. Challenges and directions in epilepsy diagnostics and therapeutics: Proceedings of the 17th Epilepsy Therapies and Diagnostics Development conference. Epilepsia 2024, 65: 846-860. PMID: 38135921, PMCID: PMC11018495, DOI: 10.1111/epi.17875.Peer-Reviewed Original ResearchConceptsTreatment of seizuresEpilepsy diagnosticsSeizure-suppressiveSeizure burdenDisease-modifying treatmentsEpilepsy therapyFunctional outcomesPreclinical developmentAnimal modelsQuality of lifePreclinical programTherapeutic targetDisease-modifyingTherapeutic candidateEpilepsySeizuresDevelopment ConferenceClinical trial executionTranslational applicationsDrugDiseaseDisease biomarkersTherapeuticsTreatmentOutcomes
2023
Glioma genetic profiles associated with electrophysiologic hyperexcitability
Tobochnik S, Dorotan M, Ghosh H, Lapinskas E, Vogelzang J, Reardon D, Ligon K, Bi W, Smirnakis S, Lee J. Glioma genetic profiles associated with electrophysiologic hyperexcitability. Neuro-Oncology 2023, 26: 323-334. PMID: 37713468, PMCID: PMC10836775, DOI: 10.1093/neuonc/noad176.Peer-Reviewed Original ResearchConceptsSomatic mutationsSomatic mutation variantsTumor genetic profileTumor mutational burdenTumor somatic mutational profilesTargeted exome sequencingRecurrent somatic mutationsNonsynonymous missense mutationsSomatic mutation profilesPreoperative epilepsyCohort of adultsTumor locationMutational burdenElectrographic seizuresPathological diagnosisWHO gradeRecurrence statusGenetic alterationsEEG monitoringMutation profilesHyperexcitabilityMultivariate analysisExome sequencingNonsense mutationTumorIctal Pain Mimicking Renal Colic
Dorotan M, Hayes N, Tobochnik S. Ictal Pain Mimicking Renal Colic. Neurology 2023, 101: 326-327. PMID: 36878707, PMCID: PMC10437013, DOI: 10.1212/wnl.0000000000207216.Peer-Reviewed Original Research
2022
Seizure Incidence in Lung Transplant Patients (P15-8.006)
Dorotan M, Bodroghy R, Dorey-Stein Z, Tsao C. Seizure Incidence in Lung Transplant Patients (P15-8.006). Neurology 2022, 98 DOI: 10.1212/wnl.98.18_supplement.3334.Peer-Reviewed Original Research
2020
Expanding the Phenotype of MDA5 Antibody Positive Dermatomyositis (1722)
Giler G, Dorotan M, Kwan J. Expanding the Phenotype of MDA5 Antibody Positive Dermatomyositis (1722). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.1722.Peer-Reviewed Original Research
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