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2017
The NRF2 transcriptional target, OSGIN1, contributes to monomethyl fumarate-mediated cytoprotection in human astrocytes
Brennan M, Matos M, Richter K, Li B, Scannevin R. The NRF2 transcriptional target, OSGIN1, contributes to monomethyl fumarate-mediated cytoprotection in human astrocytes. Scientific Reports 2017, 7: 42054. PMID: 28181536, PMCID: PMC5299414, DOI: 10.1038/srep42054.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMonomethyl fumarateCentral nervous systemDimethyl fumarateHuman astrocytesErythroid derived 2)-like 2CNS-derived cellsCell cycle inhibitionP53 nuclear translocationNrf2-dependent mechanismTherapeutic effectMultiple sclerosisNervous systemAntioxidant gene expressionTranscriptional targetsGene expressionNuclear translocationOSGIN1Bioactive metabolitesCytoprotectionPathological processesP53Neurodegenerative diseasesCell protectionAstrocytesAdministration
2015
The NRF2 transcriptional target, OSGIN1, contributes to the cytoprotective properties of monomethyl fumarate. (P1.150)
Brennan M, Matos M, Sun C, Szak S, Scannevin R. The NRF2 transcriptional target, OSGIN1, contributes to the cytoprotective properties of monomethyl fumarate. (P1.150). Neurology 2015, 84 DOI: 10.1212/wnl.84.14_supplement.p1.150.Peer-Reviewed Original ResearchCitationsDimethyl Fumarate Alters Microglia Phenotype and Protects Neurons Against Proinflammatory Toxic Microenvironments (P1.163)
Peng H, Matos M, Wipke B, Arnold H, Scannevin R. Dimethyl Fumarate Alters Microglia Phenotype and Protects Neurons Against Proinflammatory Toxic Microenvironments (P1.163). Neurology 2015, 84 DOI: 10.1212/wnl.84.14_supplement.p1.163.Peer-Reviewed Original ResearchCitationsDimethyl Fumarate and Monoethyl Fumarate Exhibit Differential Effects on KEAP1, NRF2 Activation, and Glutathione Depletion In Vitro
Brennan M, Matos M, Li B, Hronowski X, Gao B, Juhasz P, Rhodes K, Scannevin R. Dimethyl Fumarate and Monoethyl Fumarate Exhibit Differential Effects on KEAP1, NRF2 Activation, and Glutathione Depletion In Vitro. PLOS ONE 2015, 10: e0120254. PMID: 25793262, PMCID: PMC4368598, DOI: 10.1371/journal.pone.0120254.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDimethyl fumarate treatmentKelch-like ECH-associated protein 1In vitro effectsDimethyl fumarateDelayed-release dimethyl fumarateEffect of dimethyl fumarateErythroid derived 2)-like 2Treatment of psoriasisNuclear translocationDepletion in vitroRobust transcriptional responseAcute reductionDepletion of GSHECH-associated protein 1Monoethyl fumarateMultiple sclerosisProtein 1GSH levelsPharmacological propertiesTreatmentUnique actionsDegree of activationDivergent effectsDifferential effectsGSH
2014
Dimethyl fumarate alters microglia phenotype and protects neurons against proinflammatory toxic microenvironments
Peng H, Matos M, Wipke B, Arnold M, Scannevin R. Dimethyl fumarate alters microglia phenotype and protects neurons against proinflammatory toxic microenvironments. Journal Of Neuroimmunology 2014, 275: 224. DOI: 10.1016/j.jneuroim.2014.08.602.Peer-Reviewed Original ResearchCitationsDimethyl Fumarate and Monoethyl Fumarate Exhibit Differential Effects on Glutathione, Keap1 and Nrf2 Activation In Vitro (P1.204)
Scannevin R, Brennan M, Matos M, Hronowski X, Gao B, Juhasz P, Rhodes K. Dimethyl Fumarate and Monoethyl Fumarate Exhibit Differential Effects on Glutathione, Keap1 and Nrf2 Activation In Vitro (P1.204). Neurology 2014, 82 DOI: 10.1212/wnl.82.10_supplement.p1.204.Peer-Reviewed Original Research