Marcus Hughes, MD
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Assistant Professor
Biography
Dr. Marcus Hughes is an Assistant Professor of Psychiatry at Yale School of Medicine and an Attending Psychiatrist on the Interventional Psychiatry Service (IPS) at Yale-New Haven Psychiatric Hospital. He is a former chief resident of IPS and a 2023 graduate of the Yale Psychiatry Residency Program. Additionally, he is the faculty advisor for the Solomon Carter Fuller Association, involved in resident-level didactics, and an interviewer for the Yale Psychiatry Residency Program.
He is predominantly interested in equitable investigation and implementation of novel pharmacological interventions, particularly psychedelic and psychedelic-like molecules, and their application in the treatment of mood and substance use disorders. Clinical responsibilities include treating patients on the busy ketamine/esketamine, electroconvulsive therapy (ECT), and transcranial magnetic stimulation (TMS) services at Yale-New Haven Psychiatric Hospital. Dr. Hughes promotes social justice and equity in practice with a focus on cultural and structural competencies.
Dr. Hughes is a member of Alpha Omega Alpha and was an American Psychiatric Association Foundation Diversity Leadership Fellow from 2022-2024. His favorite pastimes include thinking, reading, making photographs, making paintings, listening to funk and jazz, and fixed gear cycling.
Appointments
Psychiatry
Assistant ProfessorPrimary
Other Departments & Organizations
- Interventional Psychiatry Service
- Psychiatry
Education & Training
- Chief Resident of IPS
- Yale School of Medicine (2024)
- Resident
- Yale School of Medicine (2024)
- MD
- Rutgers New Jersey Medical School (2018)
- BS
- Rutgers University , Biology (2013)
Research
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Research at a Glance
Yale Co-Authors
Publications Timeline
Michael Bloch, MD, MS
Rachel Katz, MD, BS
Publications
Featured Publications
Treatment-Resistant Depression
Hughes M, Levine S. Treatment-Resistant Depression. In: England J, ed. Encyclopedia of the Neurological Sciences. 3rd ed. Elsevier - Academic Press; 2025:177-188.ChaptersEthnoracial inclusion in clinical trials of psychedelics: a systematic review.
Hughes ME, Garcia-Romeu A. Ethnoracial inclusion in clinical trials of psychedelics: a systematic review. EClinicalMedicine 2024, 74: 102711. PMID: 39050106, DOI: 10.1016/j.eclinm.2024.102711.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2025
Letter: Food and Drug Administration Clearance of Transcranial Magnetic Stimulation for Adolescent Depression in the Absence of Data Supporting Efficacy
Kumpf K, Hughes M, Bloch M. Letter: Food and Drug Administration Clearance of Transcranial Magnetic Stimulation for Adolescent Depression in the Absence of Data Supporting Efficacy. Journal Of Child And Adolescent Psychopharmacology 2025, 35: 369-371. PMID: 40275809, DOI: 10.1089/cap.2024.0142.Commentaries, Editorials and LettersCitations
2024
Nitrous Oxide in the Treatment of Depression: A Brief Review
Hughes, M. E. Nitrous Oxide in the Treatment of Depression: A Brief Review. Am. J. Psychiatry Resid. J. 2024, 20(2), 18–21. https://doi.org/https://doi.org/10.1176/appi.ajp-rj.2024.200207Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSafe Delivery of Electroconvulsive Therapy in a Patient With Obstructive Sleep Apnea and a Hypoglossal Nerve Stimulator: A Case Report.
Hughes M, Cohen T, Ostroff R, Katz R. Safe Delivery of Electroconvulsive Therapy in a Patient With Obstructive Sleep Apnea and a Hypoglossal Nerve Stimulator: A Case Report. J ECT 2024 PMID: 39589131, DOI: 10.1097/YCT.0000000000001089.Peer-Reviewed Case Reports and Technical Notes
2023
Changing approaches to treating opioid withdrawal in the USA
Hughes M, Edinoff A, Sue K. Changing approaches to treating opioid withdrawal in the USA. The Lancet Psychiatry 2023, 10: 378-380. PMID: 37167986, DOI: 10.1016/s2215-0366(23)00145-1.Commentaries, Editorials and LettersCitationsAltmetric
2022
The Crucial Role of Black, Latinx, and Indigenous Leadership in Harm Reduction and Addiction Treatment
Hughes M, Suhail-Sindhu S, Namirembe S, Jordan A, Medlock M, Tookes HE, Turner J, Gonzalez-Zuniga P. The Crucial Role of Black, Latinx, and Indigenous Leadership in Harm Reduction and Addiction Treatment. American Journal Of Public Health 2022, 112: s136-s139. PMID: 35349317, PMCID: PMC8965189, DOI: 10.2105/ajph.2022.306807.Commentaries, Editorials and LettersCitationsAltmetric
Academic Achievements & Community Involvement
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Activities
activity Alpha Omega Alpha
05/05/2022 - PresentProfessional OrganizationsMemberactivity Integrating Psychedelic Coursework into Higher Education
06/18/2025 - PresentOral PresentationPsychedelic Science 2025DetailsDenver, CO, United StatesSponsored by Brain Futures
Honors
honor Sheldon Miller Early Career Award
12/04/2022National AwardAmerican Academy of Addiction Psychiatry
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