Madeeha Nasir
Associate Research Scientist in The Child Study CenterCards
About
Research
Publications
2025
Longitudinal associations of electroconvulsive therapy with all-cause mortality and suicide deaths in severe unipolar or bipolar depression: a systematic review and meta-analysis
Rhee T, Shim S, Nasir M, McIntyre R, Kaster T, Wilkinson S. Longitudinal associations of electroconvulsive therapy with all-cause mortality and suicide deaths in severe unipolar or bipolar depression: a systematic review and meta-analysis. BMJ Mental Health 2025, 28: e302083. PMID: 41407487, PMCID: PMC12716550, DOI: 10.1136/bmjment-2025-302083.Peer-Reviewed Original ResearchConceptsBipolar depressionElectroconvulsive therapyAll-Cause MortalityMonths of follow-upTreatment-resistant mood disordersLongitudinal associationsSuicide deathsEffects of electroconvulsive therapyAssociation of electroconvulsive therapyDiagnosis of mental disordersLongitudinal cohort study designOutcome measuresRisk of all-cause mortalityElectroconvulsive therapy useFollow-upCohort study designSchizoaffective disorderMood disordersSuicide riskMental disordersModeration analysisRandom-effects modelUsual careAdjusted HRDepression
2024
Systematic Review and Meta-Analysis: Placebo Response in Randomized Controlled Trials of Tourette’s Disorder Medications
Macul Ferreira de Barros P, Farhat L, Behling E, Nasir M, Landeros-Weisenberger A, Bloch M. Systematic Review and Meta-Analysis: Placebo Response in Randomized Controlled Trials of Tourette’s Disorder Medications. Journal Of The American Academy Of Child And Adolescent Psychiatry 2024, 64: 577-592. PMID: 39505141, DOI: 10.1016/j.jaac.2024.10.011.Peer-Reviewed Original ResearchConceptsDrug-placebo differencesMagnitude of placebo responseTourette's disorderPaper self-identifiesPlacebo responseRandomized Controlled TrialsDrug responseChronic tic disorderAssociated with greater improvementStandardized mean changePlacebo armPlacebo-controlled randomized controlled trialsPharmacological interventionsMeta-analysisAssociated with larger improvementsStudy-level factorsClinical trialsPharmacological randomized controlled trialsDrug placeboPlacebo-controlled clinical trialPsychiatric conditionsControlled TrialsTic disordersTourette syndromeTourette
2022
Efficacy of Intravenous Ketamine in Adolescent Treatment-Resistant Depression: A Randomized Midazolam-Controlled Trial
Dwyer J, Landeros-Weisenberger A, Johnson J, Londono Tobon A, Flores J, Nasir M, Couloures K, Sanacora G, Bloch M. Efficacy of Intravenous Ketamine in Adolescent Treatment-Resistant Depression: A Randomized Midazolam-Controlled Trial. FOCUS The Journal Of Lifelong Learning In Psychiatry 2022, 20: 241-251. PMID: 37153136, PMCID: PMC10153503, DOI: 10.1176/appi.focus.22020004.Peer-Reviewed Original ResearchTreatment-resistant depressionDepression Rating ScaleIntravenous ketamineClinical trialsAdolescent treatment-resistant depressionAdult treatment-resistant depressionPlacebo-controlled clinical trialSignificant short-term efficacySerious adverse eventsPrimary outcome measureSingle intravenous infusionChildren's Depression Rating ScaleCrossover clinical trialShort-term efficacyMajor depressive disorderSingle ketamine infusionSymptoms 24 hoursLater time pointsKetamine’s safetyAdverse eventsAntidepressant medicationKetamine infusionPediatric populationSignificant morbidityIntravenous infusion