Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsLuca Fabris, MD, PhD, FAASLD
Associate Professor Adjunct of Medicine (Digestive Diseases), Internal MedicineAbout
Research
Publications
2025
Cancer-associated thrombosis in cholangiocarcinoma: Exploring a phenotype of tumor aggressiveness
Fabris L, Frión-Herrera Y, Cadamuro M, Campello E, Simioni P. Cancer-associated thrombosis in cholangiocarcinoma: Exploring a phenotype of tumor aggressiveness. Biochimica Et Biophysica Acta (BBA) - Reviews On Cancer 2025, 1880: 189457. PMID: 40987389, DOI: 10.1016/j.bbcan.2025.189457.Peer-Reviewed Original ResearchVenous thromboembolismPrognostic factorsPhenotypes of tumor aggressivenessOccurrence of venous thromboembolismRisk of bleedingSubgroup of patientsCancer-associated thrombosisCancer-related morbidityLiver malignanciesTumor aggressivenessHypercoagulable stateTumor progressionWorse outcomesClinical significanceCholangiocarcinomaTreatment approachesCancer typesPrediction scoreRiskMalignancyThromboprophylaxisBleedingCase Report: jaundice in the young: the complexity of rare diseases beyond cholangiopathies
Guglielmo S, Pasin F, Biolo M, Mescoli C, Vio S, Fabris L, Simioni P. Case Report: jaundice in the young: the complexity of rare diseases beyond cholangiopathies. Frontiers In Gastroenterology 2025, 4: 1579928. DOI: 10.3389/fgstr.2025.1579928.Peer-Reviewed Original ResearchAutoimmune hemolytic anemiaInflammatory bowel diseaseSerum IgG4 levelsAutoimmune pancreatitisCorticosteroid therapyIgG4 levelsClinical presentationAssociated with elevated serum IgG4 levelsDiagnosis of type 2 AIPComplication of autoimmune pancreatitisSuspicion of autoimmune pancreatitisElevated serum IgG4 levelsRemission of jaundiceType 2 AIPAssociated with inflammatory bowel diseaseBile duct dilatationPositive Coombs testDiagnosis of Crohn's diseaseMild weight lossPancreato-biliary diseasesPresentation of diseasePale stoolsAbdominal painClinical responseUnnecessary surgeryTHU-125 Activation of coagulation system and platelet aggregation in patients with primary sclerosing cholangitis and cholangiocarcinoma
Frion-Herrera Y, Venturin C, Cadamuro M, Nuozzi G, Radu C, Mescoli C, Cillo U, Gringeri E, Campello E, Strazzabosco M, Cigliano A, Calvisi D, Simioni P, Fabris L. THU-125 Activation of coagulation system and platelet aggregation in patients with primary sclerosing cholangitis and cholangiocarcinoma. Journal Of Hepatology 2025, 82: s446-s447. DOI: 10.1016/s0168-8278(25)01271-1.Peer-Reviewed Original ResearchOncostatin M modulates the biology of cholangiocarcinoma cells and the tumor microenvironment
Porro N, Nurcis J, De Siervi S, Cadamuro M, Turato C, Mantovani S, Oliviero B, Fabris L, Mondelli M, Marra F, Parola M, Caligiuri A, Pastore M, Cannito S, Gentilini A. Oncostatin M modulates the biology of cholangiocarcinoma cells and the tumor microenvironment. Digestive And Liver Disease 2025, 57: s18. DOI: 10.1016/j.dld.2025.01.031.Peer-Reviewed Original ResearchTumor microenvironmentOncostatin MStromal cellsFibrotic tumor microenvironmentPrimary hepatic stellate cellsCultured stromal cellsHuman iCCA cell linesResistance to chemotherapyCell migrationTumor-stroma interactionsDose-dependent increaseExpression of oncostatin MCancer-associated fibroblastsHepatic stellate cellsOncostatin M receptorAggressive tumorsInvasion of iCCA cellsHuman CCA specimensPoor prognosisPeritumoral tissuesCancer-associated pathwaysIncreased cell migrationConditioned mediumTumorCancer cells
2024
Editor's Note: Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma.
Cadamuro M, Spagnuolo G, Sambado L, Indraccolo S, Nardo G, Rosato A, Brivio S, Caslini C, Stecca T, Massani M, Bassi N, Novelli E, Spirli C, Fabris L, Strazzabosco M. Editor's Note: Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma. Cancer Research 2024, 84: 3909. PMID: 39544086, DOI: 10.1158/0008-5472.can-24-3017.Peer-Reviewed Original ResearchMachine learning application to histology for the study of cholangiopathies (BiliQML): A chance to put liver biopsy back to its former glory?
Venturin C, Fabris L. Machine learning application to histology for the study of cholangiopathies (BiliQML): A chance to put liver biopsy back to its former glory? AJP Gastrointestinal And Liver Physiology 2024, 327: g733-g736. PMID: 39378378, DOI: 10.1152/ajpgi.00173.2024.Peer-Reviewed Original ResearchComparative performance of methylation DNA markers, brushing cytology, and FISH in diagnosing malignant biliary strictures.
Banales J, Lapitz A, Fabris L. Comparative performance of methylation DNA markers, brushing cytology, and FISH in diagnosing malignant biliary strictures. Hepatology 2024, 81: 389-392. PMID: 39116342, DOI: 10.1097/hep.0000000000001050.Peer-Reviewed Original ResearchProcoagulant phenotype of virus-infected pericytes is associated with portal thrombosis and intrapulmonary vascular dilations in fatal COVID-19
Cadamuro M, Lasagni A, Radu C, Calistri A, Pilan M, Valle C, Bonaffini P, Vitiello A, Toffanin S, Venturin C, Friòn-Herrera Y, Sironi S, Alessio M, Previtali G, Seghezzi M, Gianatti A, Strazzabosco M, Strain A, Campello E, Spiezia L, Palù G, Frigo A, Tosoni A, Nebuloni M, Parolin C, Sonzogni A, Simioni P, Fabris L. Procoagulant phenotype of virus-infected pericytes is associated with portal thrombosis and intrapulmonary vascular dilations in fatal COVID-19. Journal Of Hepatology 2024, 81: 872-885. PMID: 38908437, DOI: 10.1016/j.jhep.2024.06.014.Peer-Reviewed Original ResearchConceptsIntrapulmonary vascular dilatationWorsening respiratory failureSARS-CoV-2 infectionRespiratory failureFatal COVID-19Procoagulant phenotypeSARS-CoV-2Development of intrapulmonary vascular dilatationsVascular dilatationAssociated with portal thrombosisComplication of COVID-19 infectionTissue factorWork-up of patientsHuman pulmonary microvascular endothelial cellsEndothelial cellsObliterative portal venopathyPulmonary microvascular endothelial cellsAbsence of cirrhosisFatal respiratory failureAssociated with younger ageSevere liver diseaseDevelopment of hypoxemiaPathophysiology of thrombosisPortal vein branchesSevere COVID-19Mast cells and histamine in cholangiocarcinoma: exploring overlooked avenues for enhanced patient management
Fabris L, Pol J. Mast cells and histamine in cholangiocarcinoma: exploring overlooked avenues for enhanced patient management. Gut 2024, 73: 1229-1231. PMID: 38631898, DOI: 10.1136/gutjnl-2024-332288.Peer-Reviewed Original ResearchSex and Gender in Ageing and Longevity: Highlights From an International Course
Candore G, Accardi G, Aiello A, Baggio G, Bellini T, Calabrese V, Carreca A, Carreca I, Masucci A, Cattaneo M, Dato S, Di Bona D, Fabris L, Gambino C, Di Lorenzo G, Franceschi C, Ligotti M, Manfrinato M, Puca A, Tamburello M, Vassallo R, Caruso C. Sex and Gender in Ageing and Longevity: Highlights From an International Course. Translational Medicine UniSa 2024, 26: 15-29. PMID: 38560614, PMCID: PMC10980291, DOI: 10.37825/2239-9747.1049.Peer-Reviewed Original Research