Luca Pasquini, MD, PhD
Assistant Professor of Radiology and Biomedical ImagingCards
About
Research
I use neuro-imaging, including advanced MRI techniques, to enhance the integration of cognitive neuroscience into clinical practice. My research interests include brain connectivity, artificial intelligence and molecular imaging.
Publications
2024
Cognitive Control Network and Language Reorganization in Patients with Brain Tumors
Pasquini L, Napolitano A, Spitoni L, Schmid M, Dellepiane F, Jenabi M, Peck K, Holodny A. Cognitive Control Network and Language Reorganization in Patients with Brain Tumors. American Journal Of Neuroradiology 2024, ajnr.a8638. PMID: 39730156, DOI: 10.3174/ajnr.a8638.Peer-Reviewed Original ResearchCognitive control networkLanguage reorganizationResting-state fMRIHealthy controlsFunctional magnetic resonance imagingControl networkTask-based fMRIResting state networksRight-handed patientsCognitive controlLanguage lateralizationReorganize languageEffect of lateralitySpeech deficitsLaterality indexFMRIAge-matched healthy controlsRight-handednessPatient's speechBrain tumorsTask-basedCognitive networksIndependent component analysisMagnetic resonance imagingBrainGut-brain axis and neuroplasticity in health and disease: a systematic review
Di Napoli A, Pasquini L, Visconti E, Vaccaro M, Rossi-Espagnet M, Napolitano A. Gut-brain axis and neuroplasticity in health and disease: a systematic review. La Radiologia Medica 2024, 130: 327-358. PMID: 39718685, DOI: 10.1007/s11547-024-01938-0.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imaging studyDiffusion tensor imagingHealthy subjectsArterial spin labelingGut-brain axisBrain connectivityStructural magnetic resonance imagingMagnetic resonance imaging studiesInflammatory bowel syndromeAssociated with connectivityMagnetic resonance imagingGut microbiotaBowel syndromeImaging studiesTranscranial magnetic stimulationTemporal cortexNon-human subjectsResonance imagingCurrent evidenceStructural MRISomatosensory cortexPatientsPsychiatric diseasesBrain functionTensor imagingRADT-45. INTEGRATION OF FUNCTIONAL MAGNETIC RESONANCE IMAGING INTO STEREOTACTIC RADIOSURGERY PLANNING TO REDUCE SYMPTOMATIC RADIATION NECROSIS
Gui C, Jenabi M, Daly J, Gillick C, Bradley T, Sze E, Maldonado R, Tiwari A, Stember J, Mankuzhy N, Yamada Y, Pike L, Pasquini L, Peck K, Ballangrud-Popovic Å, Holodny A, Imber B. RADT-45. INTEGRATION OF FUNCTIONAL MAGNETIC RESONANCE IMAGING INTO STEREOTACTIC RADIOSURGERY PLANNING TO REDUCE SYMPTOMATIC RADIATION NECROSIS. Neuro-Oncology 2024, 26: viii83-viii83. PMCID: PMC11554023, DOI: 10.1093/neuonc/noae165.0329.Peer-Reviewed Original ResearchStereotactic radiosurgerySymptomatic RNRadiation necrosisBrain metastasesNeurological symptomsDosimetric analysisTarget coverageComplications of stereotactic radiosurgeryMonths of SRSSacrificing target coverageSymptomatic radiation necrosisUnresectable brain metastasesMonths post-SRSEloquent cortical areasFunctional magnetic resonance imagingFocal neurological symptomsMagnetic resonance imagingRadiosurgery planningPost-SRSSRS plansPrimary motorEloquent areasNeurological functionPatientsResonance imagingEvolutionary Strategies Enable Systematic and Reliable Uncertainty Quantification: A Proof-of-Concept Pilot Study on Resting-State Functional MRI Language Lateralization
Stember J, Dishner K, Jenabi M, Pasquini L, K Peck K, Saha A, Shah A, O’Malley B, Ilica A, Kelly L, Arevalo-Perez J, Hatzoglou V, Holodny A, Shalu H. Evolutionary Strategies Enable Systematic and Reliable Uncertainty Quantification: A Proof-of-Concept Pilot Study on Resting-State Functional MRI Language Lateralization. Journal Of Imaging Informatics In Medicine 2024, 38: 576-586. PMID: 38980624, PMCID: PMC11810852, DOI: 10.1007/s10278-024-01188-6.Peer-Reviewed Original ResearchOut-of-distributionDeep neuroevolutionArtificial intelligenceOut-of-distribution imagesTrustworthy artificial intelligenceTest set accuracyUncertainty quantificationComputational complexityEffective uncertainty quantificationAleatoric uncertaintyDistribution entropyMedical diagnosisUQ methodsRadiology applicationsClinical workflowOptimal strategyEnablersNeuroevolutionExpert reviewUQ approachEnsembleExpert assessmentIntelligenceMapsModel ensembleTumor-induced modifications of resting-state networks in patients with glioma
Pasquini L, Napolitano A, Schmid M, Jenabi M, Peck K, Holodny A. Tumor-induced modifications of resting-state networks in patients with glioma. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2024 DOI: 10.58530/2024/3149.Peer-Reviewed Original ResearchBrain networksHealthy controlsResting-state functional MRITumor locationResting-state networksFunctional MRIAssociated with tumor locationTumor boundariesCognitive disabilitiesTumor-induced alterationsCognitive networksBrainChi-square testTumor effectWHO-gradeFunctional alterationsEloquent areasTumor growthGlioma patientsWidespread effectsTumorPatient networksPatientsGliomaAlterationsTumors Affect the Metabolic Connectivity of the Human Brain Measured by 18F-FDG PET
Pasquini L, Jenabi M, Graham M, Peck K, Schöder H, Holodny A, Krebs S. Tumors Affect the Metabolic Connectivity of the Human Brain Measured by 18F-FDG PET. Clinical Nuclear Medicine 2024, 49: 822-829. PMID: 38693648, PMCID: PMC11300165, DOI: 10.1097/rlu.0000000000005227.Peer-Reviewed Original ResearchConceptsHealthy controlsTemporal tumorF-FDGFrontal tumorF-FDG PET/MRIKarnofsky performance scoreF-FDG PETHigh-grade gliomasLow-grade gliomasLow KPSRadiation necrosisActive tumorMetabolic brain networkMetabolic connectivityHigher KPSBrain metabolic connectivityHemispheric tumorsLow-gradeSignificant hemispheric differencesSynaptic activityTumorPatientsBetweenness centralityLeft hemisphere tumorsGlucose metabolismCongenital Malformations of the Eye: A Pictorial Review and Clinico‐Radiological Correlations
Guarnera A, Valente P, Pasquini L, Moltoni G, Randisi F, Carducci C, Carboni A, Lucignani G, Napolitano A, Romanzo A, Longo D, Gandolfo C, Rossi-Espagnet M. Congenital Malformations of the Eye: A Pictorial Review and Clinico‐Radiological Correlations. Journal Of Ophthalmology 2024, 2024: 5993083. PMID: 38322500, PMCID: PMC10846927, DOI: 10.1155/2024/5993083.Peer-Reviewed Original ResearchOcular malformationsCongenital malformationsPictorial reviewWeeks of gestationClinico-radiological correlationOphthalmologic evaluationOphthalmological findingsMalformation severityImaging findingsMalformationsComplex syndromeQuality of lifeImaging protocolVision impairmentHeterogeneous spectrumAbnormalitiesClinical radiologistsEye formationGenetic conditionsEyesCausative eventChild growthComplete absenceImage featuresGestation
2023
Case Study #8: Alpha-Therapy with Radium-223 Dichloride for Metastatic Castration-Resistant Prostate Cancer
Pasquini L, Morris M. Case Study #8: Alpha-Therapy with Radium-223 Dichloride for Metastatic Castration-Resistant Prostate Cancer. 2023, 387-405. DOI: 10.1007/978-3-031-39005-0_19.Peer-Reviewed Original ResearchMetastatic castration-resistant prostate cancerCastration-resistant prostate cancerProstate cancerRadium-223Radiopharmaceutical therapyTreatment of metastatic castration-resistant prostate cancerMinimal bone marrow toxicityRadium-223 dichlorideVisceral metastatic diseaseBone marrow toxicityNearby cancer cellsBone painMarrow toxicityMetastatic diseaseOverall survivalCombination therapyMetastatic spreadBone involvementAlpha therapyClinical developmentTreatment strategiesPalliative effectCancer cellsCancerBoneFunctional MRI in Neuro-Oncology: State of the Art and Future Directions.
Pasquini L, Peck K, Jenabi M, Holodny A. Functional MRI in Neuro-Oncology: State of the Art and Future Directions. Radiology 2023, 308: e222028. PMID: 37668519, PMCID: PMC10546288, DOI: 10.1148/radiol.222028.Peer-Reviewed Original ResearchConceptsFunctional MRIClinical functional MRIAwake brain surgeryEloquent cortexStudy human brain functionHuman brain functionRegions of activationNeuro-oncologyFunctional neuroanatomyFMRI mapsPatients' performanceBrain functionEloquent cortical areasNeurovascular uncouplingCortical areasPlanning of patientsBrain mappingCortexIntraoperative brain mappingTumor resectionSurgical approachPatient complianceFuture directionsPatient preparationHand movementsAssociation of Lack of Speech Arrest During Cortical Stimulation With Interhemispheric Reorganization of the Functional Language Network in Patients With Brain Tumors.
Pasquini L, Tao A, Ferraro G, Jenabi M, Peck K, Napolitano A, Fahy T, Brennan C, Moss N, Tabar V, Makse H, Holodny A. Association of Lack of Speech Arrest During Cortical Stimulation With Interhemispheric Reorganization of the Functional Language Network in Patients With Brain Tumors. American Journal Of Roentgenology 2023, 221: 806-816. PMID: 37377358, DOI: 10.2214/ajr.23.29434.Peer-Reviewed Original ResearchConceptsLow-grade gliomasRight-hemispheric connectivityDirect cortical stimulationFunctional MRISpeech arrestSpeech deficitsLanguage reorganizationBroca's areaLanguage networkRight hemisphereLaterality indexAwake surgeryFunctional language networkTask-based fMRIExtent of resectionCortical stimulationMultivariate logistic regressionFunctional MRI activity mapsGraph theory analysisConsecutive patientsExtended resectionTumor locationTumor sizeLanguage plasticityInterhemispheric reorganization