Le Zhao
Staff Affiliate - YNHHCards
About
Research
Publications
2025
Correction: LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and metastasis
Hou P, Zhao Y, Li Z, Yao R, Ma M, Gao Y, Zhao L, Zhang Y, Huang B, Lu J. Correction: LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and metastasis. Cell Death & Disease 2025, 16: 340. PMID: 40280900, PMCID: PMC12032008, DOI: 10.1038/s41419-025-07683-0.Commentaries, Editorials and Letters
2024
Multi-protomics analysis identified host cellular pathways perturbed by tick-borne encephalitis virus infection
Sui L, Wang W, Guo X, Zhao Y, Tian T, Zhang J, Wang H, Xu Y, Chi H, Xie H, Xu W, Liu N, Zhao L, Song G, Wang Z, Zhang K, Che L, Zhao Y, Wang G, Liu Q. Multi-protomics analysis identified host cellular pathways perturbed by tick-borne encephalitis virus infection. Nature Communications 2024, 15: 10435. PMID: 39616195, PMCID: PMC11608235, DOI: 10.1038/s41467-024-54628-w.Peer-Reviewed Original ResearchBET degrader exhibits lower antiproliferative activity than its inhibitor via EGR1 recruiting septins to promote E2F1-3 transcription in triple-negative breast cancer
Liu N, Wang S, Li M, Zhao N, Wang D, Zhang R, Yu M, Zhao L, Zhang S, Han F, Zhao Y, Liu Q. BET degrader exhibits lower antiproliferative activity than its inhibitor via EGR1 recruiting septins to promote E2F1-3 transcription in triple-negative breast cancer. Pharmacological Research 2024, 208: 107377. PMID: 39209080, DOI: 10.1016/j.phrs.2024.107377.Peer-Reviewed Original ResearchAnimalsAntineoplastic AgentsBromodomain Containing ProteinsCell Cycle ProteinsCell Line, TumorCell ProliferationE2F Transcription FactorsE2F1 Transcription FactorE2F3 Transcription FactorEarly Growth Response Protein 1FemaleGene Expression Regulation, NeoplasticHumansMediator Complex Subunit 1MiceMice, NudeTranscription FactorsTranscription, GeneticTriple Negative Breast NeoplasmsClass IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation
Cheung K, Zhao L, Sharma R, Ghosh A, Appiah M, Sun Y, Jaganathan A, Hu Y, LeJeune A, Xu F, Han X, Wang X, Zhang F, Ren C, Walsh M, Xiong H, Tsankov A, Zhou M. Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2312111121. PMID: 38657041, PMCID: PMC11067014, DOI: 10.1073/pnas.2312111121.Peer-Reviewed Original Research
2023
BRD4‐PRC2 represses transcription of T‐helper 2‐specific negative regulators during T‐cell differentiation
Zhao L, Wang Y, Jaganathan A, Sun Y, Ma N, Li N, Han X, Sun X, Yi H, Fu S, Han F, Li X, Xiao K, Walsh M, Zeng L, Zhou M, Cheung K. BRD4‐PRC2 represses transcription of T‐helper 2‐specific negative regulators during T‐cell differentiation. The EMBO Journal 2023, 42: embj2022111473. PMID: 36719036, PMCID: PMC10015369, DOI: 10.15252/embj.2022111473.Peer-Reviewed Original Research
2022
Polyamines from myeloid-derived suppressor cells promote Th17 polarization and disease progression
Hu C, Zhen Y, Ma Z, Zhao L, Wu H, Shu C, Pang B, Yu J, Xu Y, Zhang X, Wang X, Yi H. Polyamines from myeloid-derived suppressor cells promote Th17 polarization and disease progression. Molecular Therapy 2022, 31: 569-584. PMID: 36307990, PMCID: PMC9931554, DOI: 10.1016/j.ymthe.2022.10.013.Peer-Reviewed Original Research
2017
BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice
Cheung K, Lu G, Sharma R, Vincek A, Zhang R, Plotnikov A, Zhang F, Zhang Q, Ju Y, Hu Y, Zhao L, Han X, Meslamani J, Xu F, Jaganathan A, Shen T, Zhu H, Rusinova E, Zeng L, Zhou J, Yang J, Peng L, Ohlmeyer M, Walsh M, Zhang D, Xiong H, Zhou M. BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 2952-2957. PMID: 28265070, PMCID: PMC5358349, DOI: 10.1073/pnas.1615601114.Peer-Reviewed Original Research
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