Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsLauren Sippel, PhD
About
Research
Publications
2026
State of the Science: MDMA‐assisted psychotherapy for the treatment of posttraumatic stress disorder
Morland L, Rothbaum B, Sippel L, Maples‐Keller J, Schnurr P. State of the Science: MDMA‐assisted psychotherapy for the treatment of posttraumatic stress disorder. Journal Of Traumatic Stress 2026 PMID: 41820235, DOI: 10.1002/jts.70060.Peer-Reviewed Original ResearchPosttraumatic stress disorderMDMA-ATCognitive behavior mechanismStress disorderTreatment of posttraumatic stress disorderBehavioral mechanisms of actionCognitive processing therapyProlonged exposure therapyTrauma-focused therapyActive comparator conditionsPsychedelic-assisted therapyEvidence-based treatmentsProcessing therapyMDMA effectsExposure therapyPsychedelic substancesPsychotherapySample generalizabilityRemission rateMDMADisordersRandomized Controlled TrialsCompare conditionsLimitations of methodologyU.S. Food and Drug Administration
2025
A preliminary evaluation of the effectiveness of massed delivery of PTSD psychotherapy in VA residential treatment
Holliday R, Holder N, Yamokoski C, Burden J, Sippel L, Harpaz-Rotem I, Smith N. A preliminary evaluation of the effectiveness of massed delivery of PTSD psychotherapy in VA residential treatment. General Hospital Psychiatry 2025, 97: 126-129. PMID: 41086558, DOI: 10.1016/j.genhosppsych.2025.10.004.Peer-Reviewed Original ResearchConceptsResidential rehabilitation treatment programsPosttraumatic stress disorderRates of treatment completionHierarchical linear modelingResidential treatmentSymptom changeTrajectories of symptom changeTreatment programsPTSD symptom assessmentsPTSD symptom changeDelivery of psychotherapyTreatment completionRehabilitation treatment programStress disorderPreliminary supportPsychotherapyVeteransPilot projectSymptom assessmentLength of stayPost-dischargeService deliveryPilot sitesTreatment decisionsDelivery approachesPsychosis-Related Posttraumatic Stress Disorder: True, True, and Unrelated?
Rustad J, Waaland R, Coughlin B, Sippel L, Neu N, Wilson B, Schwartz R, Fuller K, Stern T. Psychosis-Related Posttraumatic Stress Disorder: True, True, and Unrelated? The Primary Care Companion For CNS Disorders 2025, 27 PMID: 39919226, DOI: 10.4088/pcc.24f03831.Peer-Reviewed Original ResearchConceptsPsychiatric symptomsComorbid psychiatric symptomsPsychiatric consultation serviceTwice-weekly roundsMassachusetts General HospitalConsultation serviceDr SternManagement of hospitalized patientsSurgical inpatientsGeneral HospitalSymptomsPsychiatricPsychiatryInpatientsAuthor affiliationServicesConsultationHospitalClinicians
2024
Novel Pharmacologic and Other Somatic Treatment Approaches for Posttraumatic Stress Disorder in Adults: State of the Evidence
Sippel L, Hamblen J, Kelmendi B, Alpert J, Carpenter L, Grzenda A, Kraguljac N, McDonald W, Rodriguez C, Widge A, Nemeroff C, Schnurr P, Holtzheimer P, Biomarkers and Treatments T. Novel Pharmacologic and Other Somatic Treatment Approaches for Posttraumatic Stress Disorder in Adults: State of the Evidence. American Journal Of Psychiatry 2024, 181: 1045-1058. PMID: 39616450, DOI: 10.1176/appi.ajp.20230950.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderStress disorderPathophysiology of posttraumatic stress disorderNon-trauma-focused psychotherapyTrauma-focused psychotherapySomatic treatment approachesEvidence-based treatmentsAntidepressant medicationSomatic treatmentsPsychiatric disordersSomatic interventionsTranscranial magnetic stimulationPsychotherapyMagnetic stimulationTreatment approachesDisordersRecommended first-line treatmentAdultsFirst-line treatmentMedicationMechanism of actionMonotherapy strategySalienceSpecific treatmentEvidenceExamining the impact of brief couples‐based posttraumatic stress disorder treatments on anger and psychological aggression in veterans and their partners
Wells S, Knopp K, Wachsman T, Dillon K, Walker H, Sippel L, Morland L, Glassman L. Examining the impact of brief couples‐based posttraumatic stress disorder treatments on anger and psychological aggression in veterans and their partners. Journal Of Traumatic Stress 2024, 38: 165-173. PMID: 39318041, PMCID: PMC11794020, DOI: 10.1002/jts.23099.Peer-Reviewed Original ResearchPosttraumatic stress disorderPsychological aggressionCouples-based interventionsCognitive-behavioral conjoint therapyPosttraumatic stress disorder treatmentIntimate partnersVeterans' mental healthAngry temperamentInterpersonal functioningConjoint therapyAnger symptomsStress disorderDisorder treatmentAngerEffect sizeMental healthAggressionVeteransTreatment conditionsActive comparatorPosttreatmentImprove aspectsLoved onesTemperamentPartnersDesign of a randomized clinical trial of brief couple therapy for PTSD augmented with intranasal oxytocin
Sippel L, Wachsman T, Kelley M, Knopp K, Khalifian C, Maglione J, Glynn S, Macdonald A, Monson C, Flanagan J, Holtzheimer P, Morland L. Design of a randomized clinical trial of brief couple therapy for PTSD augmented with intranasal oxytocin. Contemporary Clinical Trials 2024, 141: 107534. PMID: 38614447, DOI: 10.1016/j.cct.2024.107534.Peer-Reviewed Original ResearchConceptsCognitive-behavioral conjoint therapyImproving posttraumatic stress disorderPosttraumatic stress disorderIntranasal oxytocinConjoint therapyMechanisms of posttraumatic stress disorderRelationship qualityInternational units of oxytocinVA San Diego Healthcare SystemMechanisms of changeCognitive-behavioralStress disorderCouple therapyRelationship satisfactionManual treatmentPreliminary evidenceIntimate relationshipsOxytocinPotential mechanisms of actionVeteransSelf-reported communication skillsPlaceboRandomized clinical trialsCommunication skillsClinical trialsSources of Social Support and Trauma Recovery: Evidence for Bidirectional Associations from a Recently Trauma-Exposed Community Sample
Sippel L, Liebman R, Schäfer S, Ennis N, Mattern A, Rozek D, Monson C. Sources of Social Support and Trauma Recovery: Evidence for Bidirectional Associations from a Recently Trauma-Exposed Community Sample. Behavioral Sciences 2024, 14: 284. PMID: 38667080, PMCID: PMC11047467, DOI: 10.3390/bs14040284.Peer-Reviewed Original ResearchPost-traumatic stress disorderPost-traumatic stress disorder symptomsSevere PTSD symptomsSources of social supportPTSD symptomsSocial supportMeasures of post-traumatic stress disorderPost-traumatic stress disorder severityRandom intercept cross-lagged panel modelTrauma-exposed community sampleTrauma recoveryCross-lagged panel modelLevels of post-traumatic stress disorderWithin-person increasesCross-lagged coefficientsPerceived Social SupportExposed to traumaIntimate partnersIntimate partner supportTrauma-exposedRI-CLPMStress disorderCommunity sampleBidirectional associationsCommunity individualsSustaining the collaborative chronic care model in outpatient mental health: a matrixed multiple case study
Kim B, Sullivan J, Brown M, Connolly S, Spitzer E, Bailey H, Sippel L, Weaver K, Miller C. Sustaining the collaborative chronic care model in outpatient mental health: a matrixed multiple case study. Implementation Science 2024, 19: 16. PMID: 38373979, PMCID: PMC10875770, DOI: 10.1186/s13012-024-01342-2.Peer-Reviewed Original ResearchConceptsCollaborative chronic care modelEvidence-based practiceChronic Care ModelOutpatient mental health clinicMental health clinicsCare modelHealth clinicsVeterans AffairsEvidence-based Collaborative Chronic Care ModelDepartment of Veterans AffairsIntegrated Promoting ActionOutpatient mental healthCare qualityProvider interviewsHealth disparitiesImplementation trialInternal facilitatorsHealth servicesInfluence implementationProvider collaborationMental healthResearch implementationImplementation supportClinical spaceInterdisciplinary coordinationAdaptation for sustainability in an implementation trial of team-based collaborative care
Miller C, Sullivan J, Connolly S, Richardson E, Stolzmann K, Brown M, Bailey H, Weaver K, Sippel L, Kim B. Adaptation for sustainability in an implementation trial of team-based collaborative care. Implementation Research And Practice 2024, 5: 26334895231226197. PMID: 38322803, PMCID: PMC10807389, DOI: 10.1177/26334895231226197.Peer-Reviewed Original ResearchEvidence-based practiceCollaborative chronic care modelImplementation facilitatorsCare practicesImplementation trialTeam-based collaborative careAdaptation of evidence-based practicesEvidence-based practice sustainabilityImplementation strategiesChronic Care ModelMental health teamsClinical care practicesPublic health endeavorsCollaborative careCare modelHealth teamsHealthcare interventionsInternal facilitatorsHealth endeavorsImprove healthcareImplementation timeframeConsensus processFacilitation supportMedical CenterQualitative data
2023
An examination of relationship satisfaction as a predictor of outcomes of brief couple therapy for posttraumatic stress disorder
Sippel L, Knopp K, Wachsman T, Khalifian C, Glynn S, Morland L. An examination of relationship satisfaction as a predictor of outcomes of brief couple therapy for posttraumatic stress disorder. Journal Of Traumatic Stress 2023, 36: 1115-1125. PMID: 37898980, DOI: 10.1002/jts.22984.Peer-Reviewed Original ResearchConceptsRelationship satisfactionBaseline relationship satisfactionPsychosocial functioningCouple therapyCognitive-behavioral conjoint therapyBehavioral Conjoint TherapyPTSD symptom severityPosttraumatic stress disorderBrief Couple TherapyRelationship distressDyadic treatmentPTSD symptomsConjoint therapyStress disorderDistressed individualsDistressed rangeCAPS-5Military veteransSymptom severityPTSDSatisfactionIntimate relationshipsFunctioningTreatment conditionsFamily education