Krupa Jani, MD, PhD
InstructorCards
About
Research
Publications
2021
Malignancies diagnosed before and after anal squamous cell carcinomas: A SEER registry analysis
Jani K, Lu S, Murphy J, Romesser P, Jethwa K, Li D, Chundury A, Wu A, Hathout L, Hallemeier C, Jabbour S. Malignancies diagnosed before and after anal squamous cell carcinomas: A SEER registry analysis. Cancer Medicine 2021, 10: 3575-3583. PMID: 33960690, PMCID: PMC8178496, DOI: 10.1002/cam4.3909.Peer-Reviewed Original Research
2020
Increased Incidence of Malignancy Before and after Chemoradiation for Anal Squamous Cell Carcinoma: A Multi-Institutional Analysis
Jabbour S, Hallemeier C, Chang D, Lu S, Hristidis V, Jethwa K, Baclay J, Li D, Chakrani Z, Haddock M, Toesca D, Jani K, Wu A, Sandhyavenu H, Minneci M, Romesser P. Increased Incidence of Malignancy Before and after Chemoradiation for Anal Squamous Cell Carcinoma: A Multi-Institutional Analysis. International Journal Of Radiation Oncology • Biology • Physics 2020, 108: e597-e598. DOI: 10.1016/j.ijrobp.2020.07.1824.Peer-Reviewed Original ResearchThe Evolving Role of Radiotherapy in Locally Advanced Rectal Cancer and the Potential for Nonoperative Management
Khullar K, Patel N, Anderson C, Chundury A, Carpizo D, Feingold D, Grandhi M, Hochster H, Jani K, Kennedy T, Langan R, Spencer K, August D, Jabbour S, Department of Radiation Oncology R, Department of Surgery R, Division of Surgical Oncology R, Division of Medical Oncology R. The Evolving Role of Radiotherapy in Locally Advanced Rectal Cancer and the Potential for Nonoperative Management. TouchREVIEWS In Oncology & Haematology 2020, 16: 43. PMID: 32832093, PMCID: PMC7439775, DOI: 10.17925/ohr.2020.16.1.43.Peer-Reviewed Original Research
2019
PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor
Diehl K, Ge E, Weinberg D, Jani K, Allis C, Muir T. PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 22152-22157. PMID: 31611394, PMCID: PMC6825254, DOI: 10.1073/pnas.1911775116.Peer-Reviewed Original ResearchNucleation and Propagation of Heterochromatin by the Histone Methyltransferase PRC2: Geometric Constraints and Impact of the Regulatory Subunit JARID2
Ge E, Jani K, Diehl K, Müller M, Muir T. Nucleation and Propagation of Heterochromatin by the Histone Methyltransferase PRC2: Geometric Constraints and Impact of the Regulatory Subunit JARID2. Journal Of The American Chemical Society 2019, 141: 15029-15039. PMID: 31479253, PMCID: PMC6941475, DOI: 10.1021/jacs.9b02321.Peer-Reviewed Original ResearchHistone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase
Jani K, Jain S, Ge E, Diehl K, Lundgren S, Müller M, Lewis P, Muir T. Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 8295-8300. PMID: 30967505, PMCID: PMC6486736, DOI: 10.1073/pnas.1819029116.Peer-Reviewed Original Research
2016
Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape
Lu C, Jain SU, Hoelper D, Bechet D, Molden RC, Ran L, Murphy D, Venneti S, Hameed M, Pawel BR, Wunder JS, Dickson BC, Lundgren SM, Jani KS, De Jay N, Papillon-Cavanagh S, Andrulis IL, Sawyer SL, Grynspan D, Turcotte RE, Nadaf J, Fahiminiyah S, Muir TW, Majewski J, Thompson CB, Chi P, Garcia BA, Allis CD, Jabado N, Lewis PW. Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. Science 2016, 352: 844-849. PMID: 27174990, PMCID: PMC4928577, DOI: 10.1126/science.aac7272.Peer-Reviewed Original ResearchConceptsH3K36 methylationH3K36 methyltransferasesPolycomb Repressive Complex 1Repressive Complex 1H3 lysine 36Mesenchymal progenitor cellsMutant nucleosomesMethylation landscapeLysine 36H3K27 methylationHistone H3Target genesMethionine mutationMissense mutationsMethylationOncogenic mechanismsProgenitor cellsEnzymatic activityMethyltransferasesMutationsMesenchymal differentiationDifferentiationH3.1NucleosomesM mutation
2012
Computational Design of Targeted Inhibitors of Polo-Like Kinase 1 (Plk1)
Jani K, Dalafave D. Computational Design of Targeted Inhibitors of Polo-Like Kinase 1 (Plk1). Bioinformatics And Biology Insights 2012, 6: bbi.s8971. PMID: 22399850, PMCID: PMC3290105, DOI: 10.4137/bbi.s8971.Peer-Reviewed Original Research
2011
Computational Design of Small Molecules with Druglike Properties
Dalafave D, Jani K. Computational Design of Small Molecules with Druglike Properties. Biophysical Journal 2011, 100: 216a. DOI: 10.1016/j.bpj.2010.12.1393.Peer-Reviewed Original Research
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