Khaled Alok, MD, MBA
InstructorAbout
Research
Publications
2025
Long-term seizure and functional outcomes following peri-insular hemispherotomy
Moussa B, Alok K, Nawfal O, Najjar M, Farhat S, Beydoun A. Long-term seizure and functional outcomes following peri-insular hemispherotomy. Epilepsy & Behavior 2025, 173: 110801. PMID: 41175666, DOI: 10.1016/j.yebeh.2025.110801.Peer-Reviewed Original Research
2024
CGRP as a potential mediator for the sexually dimorphic responses to traumatic brain injury
Li C, Ajmal E, Alok K, Powell K, Wadolowski S, Tambo W, Turpin J, Barthélemy E, Al-Abed Y, LeDoux D. CGRP as a potential mediator for the sexually dimorphic responses to traumatic brain injury. Biology Of Sex Differences 2024, 15: 44. PMID: 38816868, PMCID: PMC11138127, DOI: 10.1186/s13293-024-00619-x.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryChronic phase of traumatic brain injuryPhase of traumatic brain injuryTraumatic brain injury outcomesCalcitonin gene-related peptideBrain injuryDepression-like behaviorFemale ratsCalcitonin gene-related peptide inhibitionCalcitonin gene-related peptide expressionEndothelial nitric oxide synthaseOutcome of traumatic brain injuryBrain sub-regionsSexually dimorphic responseSevere traumatic brain injuryAnxiety-likeElevated levels of calcitonin gene-related peptideFemale sex hormonesSpatial memoryChronic phaseResultsFemale ratsNeuroprotective effectsCortical impactDimorphic responseBiological sexBioelectronic medicine in modulation of cortical spreading depolarization and beyond
Alok K, White T, Li C. Bioelectronic medicine in modulation of cortical spreading depolarization and beyond. Neural Regeneration Research 2024, 20: 481-482. PMID: 38819057, PMCID: PMC11317948, DOI: 10.4103/nrr.nrr-d-23-02059.Peer-Reviewed Original ResearchBrivaracetam-Associated Rhabdomyolysis Requiring Renal Replacement Therapy: A Case Report and Review of the Literature
Alok K, Lin A, Dematteo C, Abrar H, Levy Z. Brivaracetam-Associated Rhabdomyolysis Requiring Renal Replacement Therapy: A Case Report and Review of the Literature. Cureus 2024, 16: e58183. PMID: 38741805, PMCID: PMC11089833, DOI: 10.7759/cureus.58183.Peer-Reviewed Original ResearchFavorable adverse event profileSerum creatine kinase levelsCreatine kinase peakAdverse event profileSide effect profileCase of rhabdomyolysisCreatine kinase levelsRare adverse reactionLife-threatening rhabdomyolysisAssociation of rhabdomyolysisAdverse Event Reporting SystemSynaptic vesicle glycoprotein 2AEvent Reporting SystemEvent profileLevetiracetam useEffect profileCase reportAntiseizure medicationsKinase levelsAdverse reactionsRhabdomyolysisBrivaracetamLevetiracetamCurrent dataSV2ASuperficial Temporal Artery-to-Middle Cerebral Artery Bypass in Ischemic Stroke With Blood Pressure-Dependent Symptoms
Huang B, Huang C, Alok K, Chen A. Superficial Temporal Artery-to-Middle Cerebral Artery Bypass in Ischemic Stroke With Blood Pressure-Dependent Symptoms. Cureus 2024, 16: e56236. PMID: 38618338, PMCID: PMC11016294, DOI: 10.7759/cureus.56236.Peer-Reviewed Original ResearchSuperficial temporal artery-to-middle cerebral arteryEC-IC bypassSingle photon emission CTSuperficial temporal artery-to-middle cerebral artery bypassNational Institutes of Health Stroke ScaleMiddle cerebral arteryEC-ICTranscranial Doppler ultrasoundCT perfusionHemodynamic insufficiencyCerebral arteryPatient's National Institutes of Health Stroke ScaleCT perfusion imagingExtracranial-intracranial (EC-IC) bypassHealth Stroke ScaleArtery bypassNeurological deficitsEmission CTRight hemiparesisDoppler ultrasoundCore infarctIschemic stroke progressionStroke progressionIschemic penumbraCerebral flow
2023
E-251 Unusual course of the facial vein encountered during direct carotid cavernous fistula embolization
Alok K, Salame J. E-251 Unusual course of the facial vein encountered during direct carotid cavernous fistula embolization. 2023, a228-a228. DOI: 10.1136/jnis-2023-snis.350.Peer-Reviewed Original ResearchUnusual Course of the Facial Vein Encountered during Direct Carotid Cavernous Fistula Embolization
Salame J, Alok K. Unusual Course of the Facial Vein Encountered during Direct Carotid Cavernous Fistula Embolization. The Arab Journal Of Interventional Radiology 2023, 07: s1-s41. DOI: 10.1055/s-0043-1763466.Peer-Reviewed Original Research
2022
Membranous obstruction of the foramen of magendie: A case report, literature review and recommendations
Habashy K, Houshiemy M, Alok K, Kawtharani S, Shehab H, Darwish H. Membranous obstruction of the foramen of magendie: A case report, literature review and recommendations. Interdisciplinary Neurosurgery 2022, 27: 101414. DOI: 10.1016/j.inat.2021.101414.Peer-Reviewed Original ResearchFourth ventricleEnlarged fourth ventricleVentricle outlet obstructionForamen of MagendieCerebrospinal fluid dynamicsMembranous obstructionOutlet obstructionTetraventricular hydrocephalusCongenital malformationsTreatment algorithmCase reportChronic headacheCerebral ventricleInflammatory processDiagnostic approachVentricleGait disturbanceAdult womenHydrocephalusFVOOObstructionForamenLiterature reviewTreatment483 Improvement in Behavioral, Cellular and Molecular Outcomes with Connexin Inhibitors Administration in a Porcine Spinal Cord Injury Model
Alok K, Moussalem C, Minassian G, Baassiri W, Kobeissy F, Jurjus A, Hamade E, Ayoub A, Habib A, Fahs A, Houshiemy M, Bsat S, Alomari S, Omeis I. 483 Improvement in Behavioral, Cellular and Molecular Outcomes with Connexin Inhibitors Administration in a Porcine Spinal Cord Injury Model. Neurosurgery 2022, 68: 119-120. DOI: 10.1227/neu.0000000000001880_483.Peer-Reviewed Original ResearchSphenoid sinus pneumatization in Middle Eastern patients - implications for endoscopic skull base approaches
Alok K, Daccache M, Hebbo E, Jabbour K, Hammoud A, Aramouni K, Hourany R. Sphenoid sinus pneumatization in Middle Eastern patients - implications for endoscopic skull base approaches. Brain And Spine 2022, 2: 101549. DOI: 10.1016/j.bas.2022.101549.Peer-Reviewed Original Research
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Yale School of Medicine
Department of Neurosurgery, 310 Cedar St.
New Haven, CT 06520
United States