Jonathan Dranoff, MD
he/him/his
Professor of Medicine (Digestive Diseases)DownloadHi-Res Photo
Cards
Appointments
Digestive Diseases
Primary
Additional Titles
Director, Steatotic Liver Disease Program , Digestive Diseases, VA Connecticut Healthcare System
Contact Info
Yale School of Medicine
Department of Medicine (Digestive Diseases), PO Box 208019
New Haven, CT 06520-8019
United States
Appointments
Digestive Diseases
Primary
Additional Titles
Director, Steatotic Liver Disease Program , Digestive Diseases, VA Connecticut Healthcare System
Contact Info
Yale School of Medicine
Department of Medicine (Digestive Diseases), PO Box 208019
New Haven, CT 06520-8019
United States
Appointments
Digestive Diseases
Primary
Additional Titles
Director, Steatotic Liver Disease Program , Digestive Diseases, VA Connecticut Healthcare System
Contact Info
Yale School of Medicine
Department of Medicine (Digestive Diseases), PO Box 208019
New Haven, CT 06520-8019
United States
About
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Titles
Professor of Medicine (Digestive Diseases)
Positions outside Yale
Director, Steatotic Liver Disease Program , Digestive Diseases, VA Connecticut Healthcare System
Biography
Dr. Dranoff is a professor of medicine in the Section of Digestive Diseases. Dr. Dranoff is a physician/scholar who has expertise in several areas in liver disease pathophysiology. As director of the VA Connecticut Healthcare System Steatotic Liver Disease program, he has an interests in exercise and coffee consumption as approaches to moderate the effect of steatotic liver disease. Dr. Dranoff is also interested in drug-induced liver injury, including acetaminophen safety/toxicity in patients with advanced chronic liver disease.
Last Updated on October 06, 2023.
Appointments
Digestive Diseases
ProfessorPrimary
Other Departments & Organizations
Education & Training
- Fellow
- Yale University School of Medicine (1999)
- Resident
- Boston University Medical Center (1996)
- MD
- Drexel University (1993)
- BA
- Lehigh University (1991)
Research
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Overview
Medical Research Interests
Acetaminophen; Chemical and Drug Induced Liver Injury; Fibrosis; Liver Cirrhosis; Non-alcoholic Fatty Liver Disease
ORCID
0000-0003-3130-1909
Research at a Glance
Yale Co-Authors
Frequent collaborators of Jonathan Dranoff's published research.
Publications Timeline
A big-picture view of Jonathan Dranoff's research output by year.
Research Interests
Research topics Jonathan Dranoff is interested in exploring.
Michael H Nathanson, MD, PhD
Dhanpat Jain, MD
Tamar Taddei, MD
Basile Njei, MD, PhD, MPH, FRCP
James Lorenzen Boyer, MD, FACEP, FAASLD, FAPS
Joseph Lim, MD
97Publications
3,506Citations
Liver Cirrhosis
Non-alcoholic Fatty Liver Disease
Acetaminophen
Fibrosis
Publications
2025
Insulin resistance, metabolic dysfunction–associated steatotic liver disease, and advanced liver fibrosis in lean US adults: a population-based study
Njei B, Abdu M, Al-Ajlouni Y, Mohamed M, Deng Y, Osta E, Kanmounye U, Vilarinho S, Dranoff J, Lim J, Md, Echouffo Tcheugui J. Insulin resistance, metabolic dysfunction–associated steatotic liver disease, and advanced liver fibrosis in lean US adults: a population-based study. Baylor University Medical Center Proceedings 2025, 38: 637-645. PMID: 40821486, PMCID: PMC12351751, DOI: 10.1080/08998280.2025.2524199.Peer-Reviewed Original ResearchCitationsConceptsQuantitative insulin sensitivity check indexAdvanced liver fibrosisHomeostasis model assessmentHOMA-IRLiver fibrosisAge-adjusted prevalenceHOMA-BInsulin resistanceAssociated with advanced liver fibrosisLean adultsLiver diseaseLean individualsHigh riskSteatotic liver diseaseModel assessmentNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveyHuman immunodeficiency virusAssociated with HOMA-IRUS National Health and Nutrition Examination SurveyInsulin sensitivity check indexB cell functionVisceral adiposity indexControlled attenuation parameterNutrition Examination Survey
2024
S1927 Sounding the Alarm on Lean MASLD in US Adults: Insights From NHANES 2017-2020
Njei B, Boateng S, Mohamed M, Al-Ajlouni Y, Dranoff J, Lim J. S1927 Sounding the Alarm on Lean MASLD in US Adults: Insights From NHANES 2017-2020. The American Journal Of Gastroenterology 2024, 119: s1380-s1381. DOI: 10.14309/01.ajg.0001037076.71899.13.Peer-Reviewed Original ResearchDiagnostic Accuracy of Transient Elastography in Hepatosteatosis in Youth With Obesity
Tas E, Sundararajan D, Lo J, Morelli N, Garcia-Reyes Y, Ware M, Rahat H, Ou X, Na X, Sundaram S, Severn C, Pyle L, Børsheim E, Vajravelu M, Muzumdar R, Dranoff J, Cree M. Diagnostic Accuracy of Transient Elastography in Hepatosteatosis in Youth With Obesity. Journal Of The Endocrine Society 2024, 8: bvae110. PMID: 38895640, PMCID: PMC11185182, DOI: 10.1210/jendso/bvae110.Peer-Reviewed Original ResearchCitationsConceptsMRI fat fractionMagnetic resonance imagingPolycystic ovary syndromeVibration-controlled transient elastographyTransient elastographyDiagnostic accuracyDiagnostic accuracy of transient elastographyAccuracy of transient elastographyReceiver-operating characteristic curveFat fractionHepatosteatosis groupSignificant obesityDiagnostic performanceClinical trialsYouden indexLiver diseaseChildhood obesityHigh riskSteatotic liver diseaseLiver fatObesityResonance imagingCharacteristic curveHepatosteatosisDiagnostic methodsSu1576 CANNABIS USE DISORDER IS ASSOCIATED WITH INCREASED RISK OF ACUTE MYOCARDIAL INFARCTION IN US ADULTS WITH MASH CIRRHOSIS: A POPULATION-BASED ANALYSIS
Njei B, Ezeani C, Mohamed M, Nso N, Boateng S, Forsah S, Ameyaw P, Dimala C, Ugwendum D, Njei L, Lim J, Dranoff J. Su1576 CANNABIS USE DISORDER IS ASSOCIATED WITH INCREASED RISK OF ACUTE MYOCARDIAL INFARCTION IN US ADULTS WITH MASH CIRRHOSIS: A POPULATION-BASED ANALYSIS. Gastroenterology 2024, 166: s-1646-s-1647. DOI: 10.1016/s0016-5085(24)04245-8.Peer-Reviewed Original ResearchAASLD Practice Guideline on blood-based noninvasive liver disease assessment of hepatic fibrosis and steatosis
Sterling R, Patel K, Duarte-Rojo A, Asrani S, Alsawas M, Dranoff J, Fiel M, Murad M, Leung D, Levine D, Taddei T, Taouli B, Rockey D. AASLD Practice Guideline on blood-based noninvasive liver disease assessment of hepatic fibrosis and steatosis. Hepatology 2024, 81: 321-357. PMID: 38489523, DOI: 10.1097/hep.0000000000000845.Peer-Reviewed Original ResearchCitationsAltmetricAASLD Practice Guideline on noninvasive liver disease assessment of portal hypertension
Sterling R, Asrani S, Levine D, Duarte-Rojo A, Patel K, Fiel M, Leung D, Taouli B, Alsawas M, Murad M, Dranoff J, Taddei T, Rockey D. AASLD Practice Guideline on noninvasive liver disease assessment of portal hypertension. Hepatology 2024, 81: 1060-1085. PMID: 38489663, DOI: 10.1097/hep.0000000000000844.Peer-Reviewed Original ResearchCitationsAltmetricAccuracy of blood-based biomarkers for staging liver fibrosis in chronic liver disease: A systematic review supporting the AASLD Practice Guideline
Patel K, Asrani S, Fiel M, Levine D, Leung D, Duarte-Rojo A, Dranoff J, Nayfeh T, Hasan B, Taddei T, Alsawaf Y, Saadi S, Majzoub A, Manolopoulos A, Alzuabi M, Ding J, Sofiyeva N, Murad M, Alsawas M, Rockey D, Sterling R. Accuracy of blood-based biomarkers for staging liver fibrosis in chronic liver disease: A systematic review supporting the AASLD Practice Guideline. Hepatology 2024, 81: 358-379. PMID: 38489517, DOI: 10.1097/hep.0000000000000842.Peer-Reviewed Original ResearchCitationsAltmetricConceptsAminotransferase-to-platelet ratio indexChronic liver diseaseNonalcoholic fatty liver diseaseHepatitis B virusBlood-based biomarkersLiver diseaseFIB-4HIV-HCV co-infectionCo-InfectionFIB-4 <Alternative to liver biopsyFIB-4 >Pre-test probabilityBlood-based testLiver disease assessmentSystematic reviewStaging liver fibrosisComprehensive search of databasesHIV-HCVFatty liver diseaseProportional odds ratiosAdvanced fibrosisLiver biopsyViral hepatitisB virusAASLD Practice Guideline on imaging-based noninvasive liver disease assessment of hepatic fibrosis and steatosis.
Sterling R, Duarte-Rojo A, Patel K, Asrani S, Alsawas M, Dranoff J, Fiel M, Murad M, Leung D, Levine D, Taddei T, Taouli B, Rockey D. AASLD Practice Guideline on imaging-based noninvasive liver disease assessment of hepatic fibrosis and steatosis. Hepatology 2024, 81: 672-724. PMID: 38489518, DOI: 10.1097/hep.0000000000000843.Peer-Reviewed Original ResearchCitationsAltmetric
2023
Coffee, adenosine, and the liver
Dranoff J. Coffee, adenosine, and the liver. Purinergic Signalling 2023, 20: 21-28. PMID: 37755557, PMCID: PMC10828332, DOI: 10.1007/s11302-023-09968-5.Peer-Reviewed Original ResearchCitationsEffects of short‐term supervised exercise training on liver fat in adolescents with obesity: a randomized controlled trial
Tas E, Landes R, Diaz E, Bai S, Ou X, Buchmann R, Na X, Muzumdar R, Børsheim E, Dranoff J. Effects of short‐term supervised exercise training on liver fat in adolescents with obesity: a randomized controlled trial. Obesity 2023, 31: 2740-2749. PMID: 37731271, PMCID: PMC11519784, DOI: 10.1002/oby.23887.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHigh-intensity interval trainingCardiorespiratory fitnessOral glucose tolerance testDual-energy X-ray absorptiometryAttenuation parameter (CAP) scoreIntrahepatic triglyceride contentSerum alanine aminotransferaseGlucose tolerance testSteatotic liver diseaseX-ray absorptiometryLiver magnetic resonanceCardiometabolic markersCardiometabolic healthExercise trainingHIIT protocolsLiver diseaseLiver fatExercise protocolTolerance testCRF testAlanine aminotransferaseInterval trainingMRI-PDFFTriglyceride contentObesity
Academic Achievements & Community Involvement
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Activities
activity National Institutes of Health
02/08/2021 - PresentPeer Review Groups and Grant Study SectionsMemberDetailsRegular member, DDK-C Study Sectionactivity American Association for the Study of Liver Disease
2015 - 2017Peer Review Groups and Grant Study SectionsChairpersonDetailsChair, Liver Fibrosis Special Interest Groupactivity National Institutes of Health
02/09/2009 - 02/04/2013Peer Review Groups and Grant Study SectionsMemberDetailsRegular Member, Hepatobiliary Pathophysiology Study Sectionactivity American Association for the Study of Liver Disease
2008 - 2010Peer Review Groups and Grant Study SectionsMemberDetailsMember, Basic Research Committee
Honors
honor Member
02/17/2022National AwardAmerican Society for Clinical InvestigationDetailsUnited Stateshonor Fellow
02/17/2022International AwardAmerican Association for the Study of Liver DiseaseDetailsUnited Stateshonor Fellow
02/17/2022International AwardAmerican Gastroenterological AssociationDetailsUnited Stateshonor Member
02/17/2022National AwardAlpha Omega AlphaDetailsUnited States
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Academic Office Number
Mobile Phone Number
Mailing Address
Yale School of Medicine
Department of Medicine (Digestive Diseases), PO Box 208019
New Haven, CT 06520-8019
United States
Administrative Support
Locations
Hepatology Clinic; Building 2; 4th Floor
Academic Office
VA Connecticut Healthcare
950 Campbell Avenue, Wing Building 2, Fl 4, Rm 140
West Haven, CT 06516
Business Office
203.932.5711 x7232Business Office Fax
203.937.3873