Jennefer Par-Young
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Associate Research Scientist
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Yale Co-Authors
Frequent collaborators of Jennefer Par-Young's published research.
Publications Timeline
A big-picture view of Jennefer Par-Young's research output by year.
Richard Bucala, MD, PhD
Insoo Kang, MD
Junghee Jenny Shin, MD, PhD
Min Shin, PhD
Hong-Jai Park
Juan Young, MD, MHS
17Publications
89Citations
Publications
2025
Enhanced antibody class switching and T cell responses to a self-amplifying RNA vs mRNA vaccine against SARS-CoV-2 spike protein 4547
Doherty E, Par-Young J, Osmani L, Filler R, Piecychna M, Abraham S, Jain N, Thambatti S, Nazaripour S, Thomas A, Leng L, Unutmaz D, Wilen C, Geall A, Kang I, Bucala R. Enhanced antibody class switching and T cell responses to a self-amplifying RNA vs mRNA vaccine against SARS-CoV-2 spike protein 4547. The Journal Of Immunology 2025, 214 DOI: 10.1093/jimmun/vkaf283.2218.Peer-Reviewed Original ResearchIncreased antibody diversification in mice vaccinated with a self-amplifying RNA versus mRNA directed against SARS-CoV-2 spike protein 9225
Par-Young J, Osmani L, Doherty E, Piecychna M, Abraham S, Jain N, Thambatti S, Nazaripour S, Thomas A, Leng L, Geall A, Kang I, Bucala R. Increased antibody diversification in mice vaccinated with a self-amplifying RNA versus mRNA directed against SARS-CoV-2 spike protein 9225. The Journal Of Immunology 2025, 214 DOI: 10.1093/jimmun/vkaf283.2654.Peer-Reviewed Original ResearchInvestigating cytotoxic and inflammatory human IL-7 receptor low effector memory CD8+ T cells in lupus
Lee S, Shin M, Lee Y, Osmani L, Seong W, Cai H, Par-Young J, Ahn J, Park H, Kim M, Unlu S, Kim H, Han M, Dong X, You S, Lee E, Kang I. Investigating cytotoxic and inflammatory human IL-7 receptor low effector memory CD8+ T cells in lupus. EBioMedicine 2025, 119: 105898. PMID: 40857939, PMCID: PMC12398881, DOI: 10.1016/j.ebiom.2025.105898.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCD8+ T cellsCD8+ T cell subsetsT cell subsetsT cellsPeripheral bloodNeutrophil extracellular trapsEffector memoryGene signatureLupus pathogenesisImaging Mass CytometryEffector memory CD8+ T cellsCD8+ T cell accumulationCD8+ T cell infiltrationKidney tissueMemory CD8+ T cellsType I IFN gene signatureCD8+ T cellsEM CD8+ T cellsAnalysis of immune cellsCytotoxic molecule expressionT cell infiltrationT cell accumulationAssociated with treatment outcomeKidney tissues of patientsT cell heterogeneityDecreased T helper 1 cell function underlies recurrent sinopulmonary infections in the 17q12 deletion syndrome
Shin J, Shin H, Gutierrez A, Yoo N, Par-Young J, Osmani L, Shin M, Sanchez-Lara P, Bucala R, Soffer G, Kang I. Decreased T helper 1 cell function underlies recurrent sinopulmonary infections in the 17q12 deletion syndrome. EBioMedicine 2025, 112: 105578. PMID: 39891996, PMCID: PMC11840234, DOI: 10.1016/j.ebiom.2025.105578.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsCD4+ T cellsRecurrent sinopulmonary infectionsT cell functionRNA-seq analysisT cellsHealthy controlsSinopulmonary infectionsRNA-seqT-betIFN-gFrequency of CD4+ T cellsCD4+ T cell functionTh1 transcription factor T-betDeletion syndromeFlow cytometryCompared to age-matched healthy controlsTranscription factor T-betDecreased T-betUrinary tract abnormalitiesAge-matched healthy controlsMultiplex assayDownstream effector cytokinesEffector cytokinesRecurrent infectionsTh17 cytokines
2024
AB1098 PHENOTYPIC ANALYSIS OF ANA POSITIVE PATIENTS REFERRED TO YALE LUPUS CLINIC
Par-Young J, Young J, Mirabella A, Kang I, Dong X. AB1098 PHENOTYPIC ANALYSIS OF ANA POSITIVE PATIENTS REFERRED TO YALE LUPUS CLINIC. Annals Of The Rheumatic Diseases 2024, 83: 1877-1878. DOI: 10.1136/annrheumdis-2024-eular.4645.Peer-Reviewed Original ResearchIL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4+ T cell responses following COVID-19 mRNA vaccination
Park H, Shin M, Shin J, Kim H, Kang B, Par-Young J, Unlu S, Afinogenova Y, Catanzaro J, Young J, Kim M, Lee S, Jeon S, You S, Racke M, Bucala R, Kang I. IL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4+ T cell responses following COVID-19 mRNA vaccination. EBioMedicine 2024, 103: 105114. PMID: 38640835, PMCID: PMC11041015, DOI: 10.1016/j.ebiom.2024.105114.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCD4+ T cellsCOVID-19 mRNA vaccinesAntigen-specific CD4+ T cell responsesT cell responsesPrimary antibody deficiencyCD4+ T cell responsesT cellsIL-1R1MRNA vaccinesIL-1IgG antibodiesAntigen-specific CD4+ T cellsCD4+ T cell responsesLevels of IL-1R1Human CD4+ T cellsIL-1 receptor 1Healthy individualsDose of COVID-19 mRNA vaccineAntigen-specific CD4IL-1R1 expressionT cell immunityRepetitive antigenic stimulationCytokines interleukin (IL)-1Immune response to virusesExpression of IL-1R1
2023
Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease
Young J, Park H, Kim M, Par-Young J, Bartlett H, Kim H, Unlu S, Osmani L, Shin M, Bucala R, van Dyck C, Allore H, Mecca A, You S, Kang I. Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease. Immunity & Ageing 2023, 20: 71. PMID: 38042785, PMCID: PMC10693128, DOI: 10.1186/s12979-023-00396-y.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPeripheral bloodT cellsAlzheimer's diseaseEM CD8Memory CD8Gene signatureAge-related immune changesIL-7 receptor alphaEffector memory CD8Strong risk factorT cell expansionAD genesAge-associated expansionImmune changesRisk factorsCD8Dementia patientsIL-7RNeuropsychological testingReceptor alphaNeurocognitive functionRT-qPCR resultsDisease severityPatientsNormal personsPOS0074-HPR EFFICACY OF E-CONSULTS COMPARED TO IN-PERSON REFERRALS OF ANA POSITIVE PATIENTS TO RHEUMATOLOGY CLINIC
Par-Young J, Young J, Kennedy F, Kang I, Dong X. POS0074-HPR EFFICACY OF E-CONSULTS COMPARED TO IN-PERSON REFERRALS OF ANA POSITIVE PATIENTS TO RHEUMATOLOGY CLINIC. Annals Of The Rheumatic Diseases 2023, 82: 248. DOI: 10.1136/annrheumdis-2023-eular.5070.Peer-Reviewed Original ResearchCitationsModulating IL-1β and its receptors shapes spike-specific CD4+ T cell responses to mRNA vaccination
Park H, Shin M, Shin J, Kim H, Kang B, Par-Young J, Unlu S, Afinogenova Y, Catanzaro J, Young J, Kim M, Lee S, You S, Racke M, Bucala R, Kang I. Modulating IL-1β and its receptors shapes spike-specific CD4+ T cell responses to mRNA vaccination. The Journal Of Immunology 2023, 210: 159.20-159.20. DOI: 10.4049/jimmunol.210.supp.159.20.Peer-Reviewed Original ResearchConceptsCOVID-19 mRNA vaccinesT cellsIL-1βIL-1R2MRNA vaccinesIL-1 receptor 1IL-1R1 expressionIL-1R2 expressionSpike-specific CD4Vaccine-induced CD4T cell immunityT cell responsesSpecific antibody productionMRNA vaccinationCell immunityDurable immunityIL-1R1IL-1BCD4Healthy individualsQuest DiagnosticsAntibody productionCell responsesReceptor 1Receptor system
2022
Correction to: Clinical features and high-risk indicators of central nervous system involvement in primary Sjögren’s syndrome
Fan W, Par-Young J, Li K, Zhang Y, Xiao P, Hua L, Leng L, Chen X, Bucala R. Correction to: Clinical features and high-risk indicators of central nervous system involvement in primary Sjögren’s syndrome. Clinical Rheumatology 2022, 42: 643-643. PMID: 36565380, PMCID: PMC9873696, DOI: 10.1007/s10067-022-06488-2.Peer-Reviewed Original Research
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