Jasmine Saini, MBBS, MS
Hospital ResidentCards
About
Research
Publications
2024
Cognition in patients with mild autonomous cortisol secretion at baseline and post-adrenalectomy
Saini J, Nathani R, Singh S, Ebbehoj A, Thangamuthu K, Suresh M, Zhang C, Nevin S, Fell V, Atkinson E, Achenbach S, Stricker N, Bancos I. Cognition in patients with mild autonomous cortisol secretion at baseline and post-adrenalectomy. European Journal Of Endocrinology 2024, 191: 636-645. PMID: 39671564, PMCID: PMC11662234, DOI: 10.1093/ejendo/lvae157.Peer-Reviewed Original ResearchConceptsMild autonomous cortisol secretionReference subjectsT-scorePost-adrenalectomyBeck Depression InventoryComposite T-scoreAutonomous cortisol secretionSF-36Urine steroid profileImpact of adrenalectomyFrailty indexCross-sectional studyShort Form-36Longitudinal cohort studyNational Institutes of Health Toolbox Cognition BatteryCohort studyMultivariate analysisSteroid profileLower cognitionCortisol secretionPatientsAssociated with lower cognitionStandardized T scoresAdrenalectomyCognitive battery6612 Both Overt And Mild Hypercortisolism Accelerate Biological Aging
Yu K, Saini J, Farr J, Vanessa F, Khosla S, Bancos I. 6612 Both Overt And Mild Hypercortisolism Accelerate Biological Aging. Journal Of The Endocrine Society 2024, 8: bvae163.126. PMCID: PMC11454948, DOI: 10.1210/jendso/bvae163.126.Peer-Reviewed Original ResearchMild autonomous cortisol secretionP16<sup>INK4a</sup> expressionAutonomous cortisol secretionCushing's syndromeAdvanced glycation end productsP16<sup>INK4a</sup>Frailty index scoreSex-matched reference subjectsCortisol secretionCell senescenceReference subjectsSingle-center cross-sectional studyCompared to reference subjectsAdvanced glycation end product readerPresence of hypercortisolismOvert Cushing's syndromeIndex scoreHistory of cardiovascular diseaseEvidence of cell senescenceAssociated with history of cardiovascular diseaseAssociated with hypercortisolismRisk of comorbiditiesAssociated with CVDAging-related comorbiditiesAssociated with history12444 Steroid Profiling And Circadian Cortisol Secretion In Patients With Mild Autonomous Cortisol Secretion: A Single-Center Cross-Sectional Study
Saini J, Singh S, Ebbehøj A, Zhang C, Nathani R, Fell V, Atkinson E, Achenbach S, Rivard A, Singh R, Grebe S, Bancos I. 12444 Steroid Profiling And Circadian Cortisol Secretion In Patients With Mild Autonomous Cortisol Secretion: A Single-Center Cross-Sectional Study. Journal Of The Endocrine Society 2024, 8: bvae163.295. PMCID: PMC11454430, DOI: 10.1210/jendso/bvae163.295.Peer-Reviewed Original ResearchUrine steroid metabolomeAutonomous cortisol secretionSteroid metabolomeReference subjectsCortisol secretionMild autonomous cortisol secretionSteroid profileSteroid productionSingle-center cross-sectional studyCompared to reference subjectsUrine steroid profileSubgroup of patientsArea under the curveHigh-resolution mass spectrometry assayCross-sectional studyCircadian cortisol secretionMass spectrometry assaySingle-centerAndrogen ratioFree cortisolCircadian secretionPatientsMetabolomicsSteroidsSeparate days12430 Urine Steroid Profiling In Patients With Unilateral And Bilateral Mild Autonomous Cortisol Secretion
Salama B, Saini J, Fell V, Atkinson E, Achenbach S. 12430 Urine Steroid Profiling In Patients With Unilateral And Bilateral Mild Autonomous Cortisol Secretion. Journal Of The Endocrine Society 2024, 8: bvae163.317. PMCID: PMC11454782, DOI: 10.1210/jendso/bvae163.317.Peer-Reviewed Original ResearchMild autonomous cortisol secretionAutonomous cortisol secretionMacronodular adrenal hyperplasiaUrine steroid profileAdrenal hyperplasiaTumor bulkDehydroepiandrosterone sulfateDST cortisolBilateral macronodular adrenal hyperplasiaInterim analysis of patientsSteroid profileCortisol secretionInterim analysisSingle-center cross-sectional studyAdrenal mass sizeUrine steroid metabolomeBilateral adrenal adenomasCompared to patientsAnalysis of patientsPost-DST cortisolProfile of patientsHigh-resolution mass spectrometry assayPrevalence of comorbiditiesSteroid profile analysisPlasma steroid profiles12434 History Of Surgical Menopause Is Associated With An Accelerated “Adrenal Aging” In Menopausal Women
Saini J, Nathani R, Larson J, Fell V, Bancos I. 12434 History Of Surgical Menopause Is Associated With An Accelerated “Adrenal Aging” In Menopausal Women. Journal Of The Endocrine Society 2024, 8: bvae163.1608. PMCID: PMC11455288, DOI: 10.1210/jendso/bvae163.1608.Peer-Reviewed Original ResearchHistory of bilateral salpingo-oophorectomyBilateral salpingo-oophorectomyBilateral salpingo-oophorectomy groupNatural menopause groupNatural menopauseComparison to womenPostmenopausal womenSteroid metabolomeMenopause groupHistory of hormone replacement therapySingle-center cross-sectional studyIncreased risk of cardiovascular diseaseExogenous glucocorticoid useChronic opioid useHistory of surgical menopauseDuration of menopauseHormone replacement therapyIncreased cardiovascular morbidityRisk of cardiovascular diseaseAssociated with abnormalitiesSalpingo-oophorectomyCross-sectional studyAdvanced malignanciesGlucocorticoid useMedian age8714 Impact of Adrenalectomy Versus Conservative Therapy On Frailty In Mild Autonomous Cortisol Secretion: A Prospective Multi-Center Cohort Study
Bassiony M, Dogra P, Šambula L, Saini J, Ambroziak U, Kastelan D, Bancos I. 8714 Impact of Adrenalectomy Versus Conservative Therapy On Frailty In Mild Autonomous Cortisol Secretion: A Prospective Multi-Center Cohort Study. Journal Of The Endocrine Society 2024, 8: bvae163.213. PMCID: PMC11454724, DOI: 10.1210/jendso/bvae163.213.Peer-Reviewed Original ResearchNonfunctioning adrenal adenomasAutonomous cortisol secretionPost-dexamethasone cortisolTreated patientsFrailty indexCortisol secretionMulti-center cohort studyCompared to patientsImpact of adrenalectomyFrailty prevalenceAdrenal adenomaPost-adrenalectomyConservative therapyMedian ageCohort studyAdrenalectomyPatientsConservative managementFrailty assessmentAdverse health outcomesPrevalenceBaselineBaseline FIHealth outcomesImproved FI12434 History Of Surgical Menopause Is Associated With An Accelerated “Adrenal Aging” In Menopausal Women
Saini J, Nathani R, Larson J, Fell V, Bancos I. 12434 History Of Surgical Menopause Is Associated With An Accelerated “Adrenal Aging” In Menopausal Women. Journal Of The Endocrine Society 2024, 8: bvae163.1695. PMCID: PMC11453475, DOI: 10.1210/jendso/bvae163.1695.Peer-Reviewed Original ResearchHistory of bilateral salpingo-oophorectomyBilateral salpingo-oophorectomyBilateral salpingo-oophorectomy groupNatural menopause groupNatural menopauseComparison to womenPostmenopausal womenSteroid metabolomeMenopause groupHistory of hormone replacement therapySingle-center cross-sectional studyIncreased risk of cardiovascular diseaseExogenous glucocorticoid useChronic opioid useHistory of surgical menopauseDuration of menopauseHormone replacement therapyIncreased cardiovascular morbidityRisk of cardiovascular diseaseAssociated with abnormalitiesSalpingo-oophorectomyCross-sectional studyAdvanced malignanciesGlucocorticoid useMedian age8740 Visceral Adipose Tissue Assessment in Patients With Mild Autonomous Cortisol Secretion Using Dual-Energy X-Ray Absorptiometry: A Cross-Sectional Study
Saini J, Zhang C, Fell V, Atkinson E, Achenbach S, Bancos I. 8740 Visceral Adipose Tissue Assessment in Patients With Mild Autonomous Cortisol Secretion Using Dual-Energy X-Ray Absorptiometry: A Cross-Sectional Study. Journal Of The Endocrine Society 2024, 8: bvae163.321. PMCID: PMC11454869, DOI: 10.1210/jendso/bvae163.321.Peer-Reviewed Original ResearchDual-energy X-ray absorptiometryVisceral adipose tissueAutonomous cortisol secretionX-ray absorptiometryFat massReference subjectsLean massComputed tomographyFull-body DXA scanMild autonomous cortisol secretionVisceral adipose tissue assessmentDual-energy X-ray absorptiometry scanCortisol secretionAssociated with increased visceral adiposityFollow-up of patientsSingle-center cross-sectional studyCompared to reference subjectsDual-energyBMI-adjusted analysisAndroid fat massCross-sectional study of adultsDexamethasone suppression testGynoid fat massPost-DST cortisolBody composition measurements12429 Overnight Metyrapone Therapy In Patients With Mild Autonomous Cortisol Secretion (MACS): An Open Label Phase 2 Interventional Study
Ferreira E, Saini J, Larson J, Atkinson E, Powell C, Nevin S, Fell V, Bancos I. 12429 Overnight Metyrapone Therapy In Patients With Mild Autonomous Cortisol Secretion (MACS): An Open Label Phase 2 Interventional Study. Journal Of The Endocrine Society 2024, 8: bvae163.251. PMCID: PMC11453951, DOI: 10.1210/jendso/bvae163.251.Peer-Reviewed Original ResearchMild autonomous cortisol secretionAutonomous cortisol secretionMacronodular adrenal hyperplasiaOvernight metyraponeManagement of patientsAdrenal adenomaMetyrapone therapyAdrenal hyperplasiaCortisol secretionAdverse eventsDehydroepiandrosterone-sulfateIncidence of treatment related adverse eventsSeverity scoreTreatment-related adverse eventsTreatment related adverse eventsIncidence of cardiovascular morbidityPatients discontinued therapyBilateral adrenal adenomasClinical severity scoreSenescence biomarkersSingle-center studyEffective medical therapyAssociated with increased prevalenceRelated adverse eventsPost-dexamethasone cortisol12437 Impact Of Wearable Brain Sensing Meditation Device On Quality Of Life In Patients Recovering From Hypercortisolism Following Surgical Intervention: A Prospective Longitudinal Cohort Study
Saini J, Fard B, Suresh M, Sandooja R, Hleibiehova Y, Atkinson E, Achenbach S, Bancos I. 12437 Impact Of Wearable Brain Sensing Meditation Device On Quality Of Life In Patients Recovering From Hypercortisolism Following Surgical Intervention: A Prospective Longitudinal Cohort Study. Journal Of The Endocrine Society 2024, 8: bvae163.217. PMCID: PMC11455429, DOI: 10.1210/jendso/bvae163.217.Peer-Reviewed Original ResearchQuality of life of patientsSF-36Quality of lifeLife of patientsIntervention groupSF-36 mental component scoreSF-36 physical componentReference cohortGlucocorticoid withdrawal syndromeProspective longitudinal cohort studyMental component scoreShort Form-36Longitudinal cohort studySymptoms of fatiguePhysical functionAssociated with improvementsFollow-upProspective longitudinal studyEndogenous hypercortisolismBody painComponent scoresImprove patientCohort studyLimited interventionNo significant improvement