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2024
A tradeoff between efficiency and robustness in the hippocampal-neocortical memory network during human and rodent sleep
Hahn M, Lendner J, Anwander M, Slama K, Knight R, Lin J, Helfrich R. A tradeoff between efficiency and robustness in the hippocampal-neocortical memory network during human and rodent sleep. Progress In Neurobiology 2024, 242: 102672. PMID: 39369838, DOI: 10.1016/j.pneurobio.2024.102672.Peer-Reviewed Original ResearchConceptsNon-REM sleepInformation coding efficiencyConsolidation processCoding efficiencyStates of disengagementPopulation codeInformation processing capacityMemory consolidationTask engagementCognitive resourcesMemory formationNeural population codesInformation-theoretic perspectiveCognitive engagementBrain statesInformation processingRobust codesIntracranial studiesMemory networkCoding regimeSleepNeocortexPattern repetitionExternal worldProcessing capacityDefining slow wave sleep without slow waves
Lendner J, Helfrich R. Defining slow wave sleep without slow waves. Trends In Neurosciences 2024, 47: 853-855. PMID: 39327160, DOI: 10.1016/j.tins.2024.09.002.Peer-Reviewed Original ResearchMultiple Intrinsic Timescales Govern Distinct Brain States in Human Sleep
Lendner J, Lin J, Larsson P, Helfrich R. Multiple Intrinsic Timescales Govern Distinct Brain States in Human Sleep. Journal Of Neuroscience 2024, 44: e0171242024. PMID: 39187378, PMCID: PMC11484545, DOI: 10.1523/jneurosci.0171-24.2024.Peer-Reviewed Original ResearchConceptsPower spectrumBrain statesDecay processAperiodic activityIntrinsic timescalesHuman intracranial electroencephalographyTimescalesDecaySpectraNeuronal oscillationsDecay functionNonrapid eye movement sleepElectrophysiological power spectrumPhysical propertiesEye movement sleepNeural populationsRegion-specific mannerHuman sleepTemporal regularityStateMovement sleepOscillationsSuperpositionPharmacological modulationSpectral Slope and Lempel–Ziv Complexity as Robust Markers of Brain States during Sleep and Wakefulness
Höhn C, Hahn M, Lendner J, Hoedlmoser K. Spectral Slope and Lempel–Ziv Complexity as Robust Markers of Brain States during Sleep and Wakefulness. ENeuro 2024, 11: eneuro.0259-23.2024. PMID: 38471778, PMCID: PMC10978822, DOI: 10.1523/eneuro.0259-23.2024.Peer-Reviewed Original ResearchConceptsImpact of sleep stagesTask engagementHealthy male human subjectsBrain statesMeasures of brain activityMale human subjectsWithin-subject designN3 sleepREM sleepSpectral slopeSleep stagesBrain activityTask performanceNeurological disordersSleepFrequency rangeHuman subjectsRobust markersLempel-Ziv complexity
2023
Human REM sleep recalibrates neural activity in support of memory formation
Lendner J, Niethard N, Mander B, van Schalkwijk F, Schuh-Hofer S, Schmidt H, Knight R, Born J, Walker M, Lin J, Helfrich R. Human REM sleep recalibrates neural activity in support of memory formation. Science Advances 2023, 9: eadj1895. PMID: 37624898, PMCID: PMC10456851, DOI: 10.1126/sciadv.adj1895.Peer-Reviewed Original ResearchConceptsRapid eye movementNeural activityMemory consolidationSleep-dependent memory consolidationIn vivo two-photon calcium imagingOvernight memory consolidationRegulation of neural activityHuman REM sleepLong-term memoryTwo-photon calcium imagingBenefit memoryLack of in vivo dataBrain activityMemory formationREM sleepNeural population activityCalcium imagingEye movementsMemoryPopulation activityNeural population dynamicsScalp electroencephalographyElectroencephalographyForgettingHow Can I Run Sleep and Anesthesia Studies with Intracranial EEG?
Lendner J, Helfrich R. How Can I Run Sleep and Anesthesia Studies with Intracranial EEG? Studies In Neuroscience, Psychology And Behavioral Economics 2023, 315-330. DOI: 10.1007/978-3-031-20910-9_20.Peer-Reviewed Original ResearchIntracranial recordingsPresence of slow wavesGeneral anesthesiaDelta oscillationsDecreased responseMechanism-of-actionSleep networksIntracranial EEGClinical routineSleep physiologyNetwork levelAnesthesiaNeural recordingsAnesthesia recordsAnesthetic drugsAnesthesia studiesNeurological disordersSlow wavesSleepNetworkContext of epilepsyEEGRoad mapBehavioral correlatesTechnical prerequisitesAn evolutionary conserved division-of-labor between archicortical and neocortical ripples organizes information transfer during sleep
van Schalkwijk F, Weber J, Hahn M, Lendner J, Inostroza M, Lin J, Helfrich R. An evolutionary conserved division-of-labor between archicortical and neocortical ripples organizes information transfer during sleep. Progress In Neurobiology 2023, 227: 102485. PMID: 37353109, DOI: 10.1016/j.pneurobio.2023.102485.Peer-Reviewed Original ResearchOscillatory and aperiodic neuronal activity in working memory following anesthesia
Lendner J, Harler U, Daume J, Engel A, Zöllner C, Schneider T, Fischer M. Oscillatory and aperiodic neuronal activity in working memory following anesthesia. Clinical Neurophysiology 2023, 150: 79-88. PMID: 37028144, DOI: 10.1016/j.clinph.2023.03.005.Peer-Reviewed Original ResearchConceptsVerbal learningMemory functionBrain activityCognitive impairmentWorking Memory TaskWorking memory accuracyAssociated with cognitive impairmentMemory taskWorking memoryMemory accuracyMemory deficitsNeuropsychological assessmentElectroencephalographic biomarkerPostoperative cognitive impairmentNeuronal activityPreoperative performanceElectroencephalography markersAperiodic activityPostoperative sessionsMale patientsGeneral anesthesiaImpairmentMemoryScalp electroencephalographyPatients
2022
Consciousness is supported by near-critical slow cortical electrodynamics
Toker D, Pappas I, Lendner J, Frohlich J, Mateos D, Muthukumaraswamy S, Carhart-Harris R, Paff M, Vespa P, Monti M, Sommer F, Knight R, D’Esposito M. Consciousness is supported by near-critical slow cortical electrodynamics. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2024455119. PMID: 35145021, PMCID: PMC8851554, DOI: 10.1073/pnas.2024455119.Peer-Reviewed Original ResearchConceptsNear-critical behaviorLow-frequency cortical oscillationsPhase transitionElectrodynamicsCortical oscillatory dynamicsElectrical oscillationsCortical oscillationsOscillatory dynamicsOscillationsInformation processingChaos testCortical information processingCortical networksTransitionPsychedelic stateCortex of humansChaosModified 0StateDisorders of consciousnessMagnetoencephalographyCortical activityUnconscious stateConscious stateGeneralized seizures
2021
Aperiodic sleep networks promote memory consolidation
Helfrich R, Lendner J, Knight R. Aperiodic sleep networks promote memory consolidation. Trends In Cognitive Sciences 2021, 25: 648-659. PMID: 34127388, PMCID: PMC9017392, DOI: 10.1016/j.tics.2021.04.009.Peer-Reviewed Original Research
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