Iara Backes, MD, PhD
Hospital ResidentCards
About
Research
Publications
2026
Antibodies targeting HSV glycoprotein B require effector functions to protect neonatal mice
Slein M, Jiménez L, Backes I, Turnbaugh E, Garland C, MacDonald S, Balazs A, Leib D, Ackerman M. Antibodies targeting HSV glycoprotein B require effector functions to protect neonatal mice. Journal Of Virology 2026, 100: e00050-26. PMID: 41800909, PMCID: PMC13098214, DOI: 10.1128/jvi.00050-26.Peer-Reviewed Original Research
2025
Eliminating interactions with the viral Fc receptor improves antibody-mediated protection against neonatal HSV infection in mice
Slein M, Backes I, Jiménez L, Kelkar N, Garland C, Khanwalkar U, Sholukh A, Johnston C, Leib D, Ackerman M. Eliminating interactions with the viral Fc receptor improves antibody-mediated protection against neonatal HSV infection in mice. Science Translational Medicine 2025, 17: eadu8579-eadu8579. PMID: 41259538, PMCID: PMC13198879, DOI: 10.1126/scitranslmed.adu8579.Peer-Reviewed Original Research
2024
Effector functions are required for broad and potent protection of neonatal mice with antibodies targeting HSV glycoprotein D
Slein M, Backes I, Garland C, Kelkar N, Leib D, Ackerman M. Effector functions are required for broad and potent protection of neonatal mice with antibodies targeting HSV glycoprotein D. Cell Reports Medicine 2024, 5: 101417. PMID: 38350452, PMCID: PMC10897633, DOI: 10.1016/j.xcrm.2024.101417.Peer-Reviewed Original Research
2023
Evidence for the Role of a Second Fc-Binding Receptor in Placental IgG Transfer in Nonhuman Primates
Rosenberg Y, Ordonez T, Khanwalkar U, Barnette P, Pandey S, Backes I, Otero C, Goldberg B, Crowley A, Leib D, Shapiro M, Jiang X, Urban L, Lees J, Hessell A, Permar S, Haigwood N, Ackerman M. Evidence for the Role of a Second Fc-Binding Receptor in Placental IgG Transfer in Nonhuman Primates. MBio 2023, 14: e00341-23. PMID: 36946726, PMCID: PMC10127586, DOI: 10.1128/mbio.00341-23.Peer-Reviewed Original Research
2022
Maternally transferred mAbs protect neonatal mice from HSV-induced mortality and morbidity
Backes I, Byrd B, Slein M, Patel C, Taylor S, Garland C, MacDonald S, Balazs A, Davis S, Ackerman M, Leib D. Maternally transferred mAbs protect neonatal mice from HSV-induced mortality and morbidity. Journal Of Experimental Medicine 2022, 219: e20220110. PMID: 36156707, PMCID: PMC9516843, DOI: 10.1084/jem.20220110.Peer-Reviewed Original ResearchMonoclonal antibody therapy of herpes simplex virus: An opportunity to decrease congenital and perinatal infections
Backes I, Leib D, Ackerman M. Monoclonal antibody therapy of herpes simplex virus: An opportunity to decrease congenital and perinatal infections. Frontiers In Immunology 2022, 13: 959603. PMID: 36016956, PMCID: PMC9398215, DOI: 10.3389/fimmu.2022.959603.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2020
Hinge length contributes to the phagocytic activity of HIV-specific IgG1 and IgG3 antibodies
Chu T, Crowley A, Backes I, Chang C, Tay M, Broge T, Tuyishime M, Ferrari G, Seaman M, Richardson S, Tomaras G, Alter G, Leib D, Ackerman M. Hinge length contributes to the phagocytic activity of HIV-specific IgG1 and IgG3 antibodies. PLOS Pathogens 2020, 16: e1008083. PMID: 32092122, PMCID: PMC7058349, DOI: 10.1371/journal.ppat.1008083.Peer-Reviewed Original Research
2017
Maternal Antiviral Immunoglobulin Accumulates in Neural Tissue of Neonates To Prevent HSV Neurological Disease
Jiang Y, Patel C, Manivanh R, North B, Backes I, Posner D, Gilli F, Pachner A, Nguyen L, Leib D. Maternal Antiviral Immunoglobulin Accumulates in Neural Tissue of Neonates To Prevent HSV Neurological Disease. MBio 2017, 8: 10.1128/mbio.00678-17. PMID: 28679745, PMCID: PMC5573671, DOI: 10.1128/mbio.00678-17.Peer-Reviewed Original Research
2015
Brain-derived neurotrophic factor modulates angiotensin signaling in the hypothalamus to increase blood pressure in rats
Erdos B, Backes I, McCowan M, Hayward L, Scheuer D. Brain-derived neurotrophic factor modulates angiotensin signaling in the hypothalamus to increase blood pressure in rats. AJP Heart And Circulatory Physiology 2015, 308: h612-h622. PMID: 25576628, PMCID: PMC4360054, DOI: 10.1152/ajpheart.00776.2014.Peer-Reviewed Original ResearchAdrenal MedullaAngiotensin II Type 1 Receptor BlockersAngiotensinsAnimalsBlood PressureBody WeightBrain-Derived Neurotrophic FactorCardiovascular SystemDependovirusGene Transfer TechniquesGenetic VectorsHeart RateHypertensionInfusions, IntraventricularMaleParaventricular Hypothalamic NucleusProto-Oncogene MasProto-Oncogene ProteinsRats, Sprague-DawleyReceptor, Angiotensin, Type 1Receptors, G-Protein-CoupledRenin-Angiotensin SystemSignal TransductionStress, PsychologicalSympathetic Nervous SystemTime FactorsTyrosine 3-MonooxygenaseUp-Regulation
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