Robust pleiotropy-decomposed polygenic scores identify distinct contributions to elevated coronary artery disease polygenic risk
Hu J, Ye Y, Zhang C, Ruan Y, Natarajan P, Zhao H. Robust pleiotropy-decomposed polygenic scores identify distinct contributions to elevated coronary artery disease polygenic risk. PLOS Computational Biology 2025, 21: e1013191. PMID: 40570042, PMCID: PMC12212871, DOI: 10.1371/journal.pcbi.1013191.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresCAD-PRSUK BiobankCoronary artery disease polygenic risk scoreSummary-level dataCAD-related traitsSamples of European ancestryCoronary artery diseaseHigh-risk individualsPotential genetic heterogeneityCurrent smokingPolygenic scoresPolygenic riskTargeted interventionsEuropean ancestryRisk scorePleiotropic regionsRisk predictionGenetic heterogeneityBiological functionsPleiotropySignificant interactionPhenotypic heterogeneityBlood pressureDisease interpretation
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