Hanah Georges, PhD
Associate Research ScientistAbout
Research
Publications
2025
Identification of transcriptome markers associated with in vitro bovine embryo quality in single embryos and biopsies
Guzeloglu A, Bishop J, Georges H, Braun H, Menjivar N, Marquez M, Hansen T, Barfield J. Identification of transcriptome markers associated with in vitro bovine embryo quality in single embryos and biopsies. Biology Of Reproduction 2025, ioaf260. PMID: 41342381, DOI: 10.1093/biolre/ioaf260.Peer-Reviewed Original ResearchIntermediate Signaling Mechanisms Regulating Human Fetal Membrane Responses to Gram‐Positive Bacterial Peptidoglycan
Georges H, Fischer A, Abrahams V. Intermediate Signaling Mechanisms Regulating Human Fetal Membrane Responses to Gram‐Positive Bacterial Peptidoglycan. American Journal Of Reproductive Immunology 2025, 93: e70090. PMID: 40435036, PMCID: PMC12124414, DOI: 10.1111/aji.70090.Peer-Reviewed Original ResearchConceptsToll-like receptorsPro-inflammatory cytokines IL-1bFetal membrane explantsHuman FM explantsPathogenesis of chorioamnionitisP65-NFkBResponse to Gram-positive bacteriaP38 MAPKElevated levelsTLR2 agonist peptidoglycanCytokines IL-1bChemokine IL-8FM explantsNeonatal morbidityPreterm birthStimulation of TLR4Fetal membranesMembrane weakeningIL-1BIL-8TLR7/8 activationMembrane explantsSecreted factorsERK signalingLipopolysaccharide stimulationPostnatal Epigenetic Alterations in Calves Persistently Infected with Bovine Viral Diarrhea Virus
Kincade J, Murtazina D, Georges H, Gonzalez-Berrios C, Bishop J, Engle T, Henao-Tamayo M, Eder J, McDonald E, Deines D, Wright B, Van Campen H, Hansen T. Postnatal Epigenetic Alterations in Calves Persistently Infected with Bovine Viral Diarrhea Virus. Viruses 2025, 17: 708. PMID: 40431719, PMCID: PMC12115714, DOI: 10.3390/v17050708.Peer-Reviewed Original ResearchBuprenorphine induces human fetal membrane sterile inflammation
Lynn T, Kelleher M, Georges H, McCauley E, Logan R, Yonkers K, Abrahams V. Buprenorphine induces human fetal membrane sterile inflammation. Journal Of Reproductive Immunology 2025, 168: 104445. PMID: 39914058, PMCID: PMC11890952, DOI: 10.1016/j.jri.2025.104445.Peer-Reviewed Original ResearchConceptsOpioid-use disorderPreterm birthToll-like receptor 4Prostaglandin E2Sterile inflammationRate of preterm birthAssociated with pregnancy complicationsInnate immune toll-like receptor 4Maternal-fetal interfaceNeutrophil chemokine IL-8Induce sterile inflammationM-opioid receptorCytokines IL-1bInflammatory cytokines IL-6Chemokine IL-8Cytokines IL-6Maternal morbidityPregnancy complicationsOpioid useOpioid-usersHuman FMInflammatory profileMembrane weakeningIL-1BPreterm
2024
Predictors of Inflammation-Mediated Preterm Birth
Georges H, Norwitz E, Abrahams V. Predictors of Inflammation-Mediated Preterm Birth. Physiology 2024, 40: 26-36. PMID: 39106300, PMCID: PMC11918307, DOI: 10.1152/physiol.00022.2024.Peer-Reviewed Original ResearchEpigenetic Modifications of White Blood Cell DNA Caused by Transient Fetal Infection with Bovine Viral Diarrhea Virus
Van Campen H, Bishop J, Brink Z, Engle T, Gonzalez-Berrios C, Georges H, Kincade J, Murtazina D, Hansen T. Epigenetic Modifications of White Blood Cell DNA Caused by Transient Fetal Infection with Bovine Viral Diarrhea Virus. Viruses 2024, 16: 721. PMID: 38793603, PMCID: PMC11125956, DOI: 10.3390/v16050721.Peer-Reviewed Original ResearchTLR8‐activating miR‐146a‐3p is an intermediate signal contributing to fetal membrane inflammation in response to bacterial LPS
Georges H, Cassin C, Tong M, Abrahams V. TLR8‐activating miR‐146a‐3p is an intermediate signal contributing to fetal membrane inflammation in response to bacterial LPS. Immunology 2024, 172: 577-587. PMID: 38631842, PMCID: PMC11223956, DOI: 10.1111/imm.13794.Peer-Reviewed Original ResearchMiR-146a-3pPreterm birthFetal membranesToll-like receptorsExpression of miR-146a-3pLipopolysaccharide exposureMouse model of pregnancyIL-8Response to bacterial LPSAssociated with chorioamnionitisFetal membrane inflammationHuman FM explantsMouse fetal membranesInduced preterm birthBacterial lipopolysaccharideMaternal-fetal interfaceDanger signalsWild-type miceIn Vivo Mouse ModelModel of pregnancyInterleukin (IL)-8Pro-inflammatory roleResponse to bacterial lipopolysaccharideAssociated with elevated levelsResponse to LPS
2023
123 Identification of transcriptome markers for bovine embryo quality
Guzeloglu A, Bishop J, Georges H, Marquez M, Menjivar N, Hansen T, Barfield J. 123 Identification of transcriptome markers for bovine embryo quality. Reproduction Fertility And Development 2023, 36: 214-215. DOI: 10.1071/rdv36n2ab123.Peer-Reviewed Original Research
2022
Epigenomic and Proteomic Changes in Fetal Spleens Persistently Infected with Bovine Viral Diarrhea Virus: Repercussions for the Developing Immune System, Bone, Brain, and Heart
Georges H, Van Campen H, Bielefeldt-Ohmann H, Hansen T. Epigenomic and Proteomic Changes in Fetal Spleens Persistently Infected with Bovine Viral Diarrhea Virus: Repercussions for the Developing Immune System, Bone, Brain, and Heart. Viruses 2022, 14: 506. PMID: 35336913, PMCID: PMC8949278, DOI: 10.3390/v14030506.Peer-Reviewed Original Research
2020
Fetal Lymphoid Organ Immune Responses to Transient and Persistent Infection with Bovine Viral Diarrhea Virus
Knapek K, Georges H, Van Campen H, Bishop J, Bielefeldt-Ohmann H, Smirnova N, Hansen T. Fetal Lymphoid Organ Immune Responses to Transient and Persistent Infection with Bovine Viral Diarrhea Virus. Viruses 2020, 12: 816. PMID: 32731575, PMCID: PMC7472107, DOI: 10.3390/v12080816.Peer-Reviewed Original Research