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Research Assistant 1 HSS
Biography
Geena received a bachelor's degree in Psychology from Brown University. While pursuing her bachelor's, she complemented her studies by pursuing clinical work within programs focusing on schizophrenia, mood disorders, and addiction. Geena is currently a postgraduate associate in Anticevic Lab at Yale University School of Psychiatry.
Last Updated on October 07, 2024.
Research
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Geena Fram's published research.
Publications Timeline
A big-picture view of Geena Fram's research output by year.
Nicole Popp Santamauro, MA
Christopher Pittenger, MD, PhD
John Krystal, MD
Stephen Kichuk, MPH
Toral Surti, MD, PhD
Anahita Bassir Nia, MD
9Publications
41Citations
Publications
2025
Acute and post-dosing effects of single-dose psilocybin for obsessive-compulsive disorder in a randomized, double-blind, placebo-controlled trial: an interpretative phenomenological analysis
Ching T, Stahnke B, Shnayder S, Agin-Liebes G, Adams T, Amoroso L, Baiz O, Belser A, Bohner C, Burke M, D’Amico E, DePalmer G, Eilbott J, Fram G, Grazioplene R, Hokanson J, Jankovsky A, Kichuk S, Martins B, Purohit P, Schaer H, Sierra Y, Witherow C, Pittenger C, Kelmendi B. Acute and post-dosing effects of single-dose psilocybin for obsessive-compulsive disorder in a randomized, double-blind, placebo-controlled trial: an interpretative phenomenological analysis. Frontiers In Psychiatry 2025, 16: 1726818. PMID: 41450831, PMCID: PMC12728583, DOI: 10.3389/fpsyt.2025.1726818.Peer-Reviewed Original ResearchAltmetricConceptsObsessive-compulsive disorderObsessive-compulsive disorder symptomsPsilocybin experienceInterpretative phenomenological analysisSubjective effectsTreatment-refractory obsessive-compulsive disorderRandomized placebo-controlled trialSubjective effects of psilocybinEffects of psilocybinEvidence-based psychotherapiesAcute effectsPhenomenological analysisModerate to strong influencePsilocybin doseBehavioral effectsTherapeutic changeHigher-order themesPlacebo-controlled trialPsilocybinNon-directive supportDouble-blindParticipants' perspectivesDisordersAcute interferenceParticipantsA translational neuroscience & computational evaluation of a D1R partial agonist for schizophrenia (TRANSCENDS): Rationale and study design of a brain-based clinical trial
Fonteneau C, Tamayo Z, Price A, Pan L, Afriyie-Agyemang Y, Agrawal S, Butler A, Cail C, Calkins M, Chakilam S, Forselius-Bielen K, Fram G, Frazier A, Gil R, Govil P, Gray D, Grinband J, Gur R, Haubold N, Heffernan Z, Heneks M, Kegeles L, Kohler C, Lin C, Lu J, Mayer M, Pham P, Perlman G, Rahmati M, Ranganathan M, Santamauro N, Schutte C, Selloni A, Van Snellenberg J, Surti T, Wolf D, Zharyy C, Group T, Abi-Dargham A, Gur R, Lieberman J, Kantrowitz J, Anticevic A, Cho Y, Krystal J. A translational neuroscience & computational evaluation of a D1R partial agonist for schizophrenia (TRANSCENDS): Rationale and study design of a brain-based clinical trial. Journal Of Psychiatric Research 2025 DOI: 10.1016/j.jpsychires.2025.12.020.Peer-Reviewed Original ResearchConceptsPartial agonistCognitive impairmentSpatial working memoryDouble-blind doseWorking memoryD1/D5 receptorsFunctional neuroimagingNeural mechanismsSchizophreniaTranslational neuroscienceCognitive paradigmNeural circuitsUntreated symptomsD1RDecades of researchFMRIClinical trialsMicro-circuitryNeuroscienceAgonistsImpairmentStudy designD1/D5Clinical dataNeuroimaging
2024
Sexual orientation-themed obsessive-compulsive disorder in a lesbian woman: Phenomenology and implications for affirmative assessment and treatment
Schild S, Moore A, Mattera E, Fitzpatrick M, Entezar T, Fram G, Ching T. Sexual orientation-themed obsessive-compulsive disorder in a lesbian woman: Phenomenology and implications for affirmative assessment and treatment. Psychiatry Research Case Reports 2024, 3: 100211. DOI: 10.1016/j.psycr.2024.100211.Peer-Reviewed Original ResearchAltmetricConceptsSexual identitySexual orientation questionsObsessive-compulsive disorderInternalized homophobiaLesbian womenLGBTQ+ individualsAffirming careSexual orientationHeterosexual samplesCisgender womenAffirmative mannerLGBTQ+Orientation questionsHeterosexual patientsIntrusive doubtsCase exampleIdentityHomophobiaTransgenderWomenDanielleSexualityTherapy proceduresDisordersCommunityCorrigendum: Safety, feasibility, tolerability, and clinical effects of repeated psilocybin dosing combined with non-directive support in the treatment of obsessive-compulsive disorder: protocol for a randomized, waitlist-controlled trial with blinded ratings
Ching T, Amoroso L, Bohner C, D'Amico E, Eilbott J, Entezar T, Fitzpatrick M, Fram G, Grazioplene R, Hokanson J, Jankovsky A, Kichuk S, Martins B, Patel P, Schaer H, Shnayder S, Witherow C, Pittenger C, Kelmendi B. Corrigendum: Safety, feasibility, tolerability, and clinical effects of repeated psilocybin dosing combined with non-directive support in the treatment of obsessive-compulsive disorder: protocol for a randomized, waitlist-controlled trial with blinded ratings. Frontiers In Psychiatry 2024, 15: 1372373. PMID: 38435972, PMCID: PMC10905264, DOI: 10.3389/fpsyt.2024.1372373.Peer-Reviewed Original ResearchSafety, feasibility, tolerability, and clinical effects of repeated psilocybin dosing combined with non-directive support in the treatment of obsessive-compulsive disorder: protocol for a randomized, waitlist-controlled trial with blinded ratings
Ching T, Amoroso L, Bohner C, D’Amico E, Eilbott J, Entezar T, Fitzpatrick M, Fram G, Grazioplene R, Hokanson J, Jankovsky A, Kichuk S, Martins B, Patel P, Schaer H, Shnayder S, Witherow C, Pittenger C, Kelmendi B. Safety, feasibility, tolerability, and clinical effects of repeated psilocybin dosing combined with non-directive support in the treatment of obsessive-compulsive disorder: protocol for a randomized, waitlist-controlled trial with blinded ratings. Frontiers In Psychiatry 2024, 14: 1278823. PMID: 38264632, PMCID: PMC10803438, DOI: 10.3389/fpsyt.2023.1278823.Peer-Reviewed Original ResearchCitationsAltmetricConceptsObsessive-compulsive disorderPrimary outcomeNon-directive supportClinical effectsTreatment-refractory obsessive-compulsive disorderRefractory obsessive-compulsive disorderSingle-dose trialBlinded ratingsWaitlist-controlled trialDose selection strategiesOCD symptom reductionTreatment of OCDEffects of psilocybinSingle-site trialOCD symptomsInstitutional review boardBlinded independent ratersTrials of psilocybinYale-Brown ObsessiveWaitlist control designPrimary endpointMore dosesFuture trialsSingle dosePsilocybin treatment
2023
523. Analyzing Temporal Stability of Working Memory Deficits in Early-Course Psychosis Spectrum Disorders
Schutte C, Rahmati M, Fonteneau C, Fram G, Schleifer C, Adkinson B, Kolabaric A, Hill N, Santamauro N, Murray J, Repovš G, Cho Y, Anticevic A. 523. Analyzing Temporal Stability of Working Memory Deficits in Early-Course Psychosis Spectrum Disorders. Biological Psychiatry 2023, 93: s305-s306. DOI: 10.1016/j.biopsych.2023.02.763.Peer-Reviewed Original Research
2022
Illness Phase as a Key Assessment and Intervention Window for Psychosis
Kohler C, Wolf D, Abi-Dargham A, Anticevic A, Cho Y, Fonteneau C, Gil R, Girgis R, Gray D, Grinband J, Javitch J, Kantrowitz J, Krystal J, Lieberman J, Murray J, Ranganathan M, Santamauro N, Van Snellenberg J, Tamayo Z, Group T, D'Souza D, Srihari V, Gueorguieva R, Patel P, Forselius-Bielen K, Lu J, Butler A, Fram G, Afriyie-Agyemang Y, Selloni A, Cadavid L, Gomez-Luna S, Gupta A, Radhakrishnan R, Rashid A, Aker R, Abrahim P, Nia A, Surti T, Kegeles L, Carlson M, Goldberg T, Gangwisch J, Benedict E, Govil P, Brazis S, Mayer M, de la Garrigue N, Fallon N, Baumvoll T, Abeykoon S, Perlman G, Bobchin K, Elliott M, Schmidt L, Rush S, Port A, Heffernan Z, Laney N, Kantor J, Hohing T, Gur R, Gur R, Calkins M. Illness Phase as a Key Assessment and Intervention Window for Psychosis. Biological Psychiatry Global Open Science 2022, 3: 340-350. PMID: 37519466, PMCID: PMC10382701, DOI: 10.1016/j.bpsgos.2022.05.009.Peer-Reviewed Original ResearchCitationsConceptsIllness phasePotential critical windowsPhase-specific biomarkersDopaminergic abnormalitiesFunctional outcomeSpecialty careSymptom assessmentIllness stageChronic illnessClinical assessmentIllness trajectoryNeurophysiological biomarkersFunctional abnormalitiesClinical careEarly psychosisMemory dysfunctionPsychotic disordersTreatment targetsAllostatic adaptationIntervention windowClinical programsBrain developmentCritical windowDysfunctionIllness
2021
Dopamine D1R Receptor Stimulation as a Mechanistic Pro-cognitive Target for Schizophrenia
Abi-Dargham A, Javitch JA, Slifstein M, Anticevic A, Calkins ME, Cho YT, Fonteneau C, Gil R, Girgis R, Gur RE, Gur RC, Grinband J, Kantrowitz J, Kohler C, Krystal J, Murray J, Ranganathan M, Santamauro N, Van Snellenberg J, Tamayo Z, Wolf D, D’Souza D, Srihari V, Gueorguieva R, Patel P, Forselius-Bielen K, Lu J, Butler A, Fram G, Afriyie-Agyemang Y, Selloni A, Cadavid L, Gomez-Luna S, Gupta A, Radhakrishnan R, Rashid A, Aker R, Abrahim P, Nia A, Surti T, Kegeles L, Carlson M, Goldberg T, Gangwisch J, Benedict E, Govil P, Brazis S, Mayer M, de la Garrigue N, Fallon N, Baumvoll T, Abeykoon S, Perlman G, Bobchin K, Elliott M, Schmidt L, Rush S, Port A, Heffernan Z, Laney N, Kantor J, Hohing T, Gray D, Lieberman J. Dopamine D1R Receptor Stimulation as a Mechanistic Pro-cognitive Target for Schizophrenia. Schizophrenia Bulletin 2021, 48: 199-210. PMID: 34423843, PMCID: PMC8781338, DOI: 10.1093/schbul/sbab095.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCortical dopamine neurotransmissionPositive allosteric modulationImportant therapeutic targetPF-06412562Dopaminergic receptorsD1R stimulationDA levelsTolerable dosesLevel of stimulationDopamine neurotransmissionReceptor stimulationTherapeutic targetPartial agonistCognitive deficitsBiased agonismFull agonismTarget engagementAllosteric modulationNew drugsStimulationPoor bioavailabilitySchizophreniaOptimal stimulationDrugsExpression levels
2020
Mapping Neurodevelopmental Trajectories of Thalamo-Cortical Systems Across the Mental Health Spectra
Fonteneau C, Howell A, Fram G, Butler A, Afriyie-Agyemang Y, Ji L, Repovs G, Woodward N, Anticevic A. Mapping Neurodevelopmental Trajectories of Thalamo-Cortical Systems Across the Mental Health Spectra. Biological Psychiatry 2020, 87: s411-s412. DOI: 10.1016/j.biopsych.2020.02.1050.Peer-Reviewed Original Research
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