About
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Gangyi Wu's published research.
Yong-Hui Jiang, MD, PhD
Publications
2011
Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3
Wang X, McCoy PA, Rodriguiz RM, Pan Y, Je HS, Roberts AC, Kim CJ, Berrios J, Colvin JS, Bousquet-Moore D, Lorenzo I, Wu G, Weinberg RJ, Ehlers MD, Philpot BD, Beaudet AL, Wetsel WC, Jiang YH. Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3. Human Molecular Genetics 2011, 20: 3093-3108. PMID: 21558424, PMCID: PMC3131048, DOI: 10.1093/hmg/ddr212.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPostsynaptic densityMajor clinical featuresHomer1b/cRole of Shank3Activity-dependent redistributionAutism spectrum disorderLong-term potentiationHuman ASD patientsSynaptic scaffolding proteinsHomozygous mutant miceClinical featuresMajor isoformsSynaptic dysfunctionAbnormal social behaviorCA1 hippocampusMale miceCognitive dysfunctionSynaptic transmissionExcitatory synapsesDendritic spinesMotor coordinationAMPA receptorsBehavioral abnormalitiesSHANK3 mutationsSevere impairment
2005
Ubiquitination of RhoA by Smurf1 promotes neurite outgrowth
Bryan B, Cai Y, Wrighton K, Wu G, Feng X, Liu M. Ubiquitination of RhoA by Smurf1 promotes neurite outgrowth. FEBS Letters 2005, 579: 1015-1019. PMID: 15710384, DOI: 10.1016/j.febslet.2004.12.074.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsRhoA protein levelsNeurite outgrowthE3 ubiquitin ligaseProteasome inhibitor MG132Protein levelsNon-neuronal cell typesIntracellular asymmetryCell polarityRho familyRho GTPasesUbiquitin ligasePromotes Neurite OutgrowthSubsequent ubiquitinationProteasomal degradationProtrusive activityEssential regulatorInhibitor MG132RhoA activitySmurf1Axonal pathfindingUbiquitinationNeuro2a cellsRhoACell typesProtrusion sites
2004
GEFT, A Rho Family Guanine Nucleotide Exchange Factor, Regulates Neurite Outgrowth and Dendritic Spine Formation*
Bryan B, Kumar V, Stafford L, Cai Y, Wu G, Liu M. GEFT, A Rho Family Guanine Nucleotide Exchange Factor, Regulates Neurite Outgrowth and Dendritic Spine Formation*. Journal Of Biological Chemistry 2004, 279: 45824-45832. PMID: 15322108, DOI: 10.1074/jbc.m406216200.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH KeywordsAnimalsCdc42 GTP-Binding ProteinCells, CulturedGuanine Nucleotide Exchange FactorsHumansNeuritesNF-kappa BP21-Activated KinasesProtein Serine-Threonine KinasesRac1 GTP-Binding ProteinRatsRats, Sprague-DawleyRho Guanine Nucleotide Exchange FactorsTranscription Factor AP-1Transcriptional ActivationConceptsGuanine nucleotide exchange factorsNucleotide exchange factorsExchange factorRho family guanine nucleotide-exchange factorNeurite outgrowthState of Rac1Dendritic spine formationCell fate determinationActin cytoskeletal organizationExchange of GDPActivation of RacNormal cell growthRac1/Cdc42Spine formationFate determinationEukaryotic cellsGene regulationNeuroblastoma cellsSmall GTPasesActive GTPDbl familyRho familyCellular processesRho GTPasesCytoskeletal organization
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