Gabriel P. A. Costa, MD
Postdoctoral AssociateDownloadHi-Res Photo
Cards
Education
MD
Universidade de Ribeirão Preto, Medicine (2024)
Universidade de Ribeirão Preto, Medicine (2024)
Pain and Addiction Interaction Neuroscience (PAIN) Lab
Publications Overview
- 32 Publications
- 106 Citations
- 19 Yale Co-Authors
Education
MD
Universidade de Ribeirão Preto, Medicine (2024)
Universidade de Ribeirão Preto, Medicine (2024)
Pain and Addiction Interaction Neuroscience (PAIN) Lab
Publications Overview
- 32 Publications
- 106 Citations
- 19 Yale Co-Authors
Education
MD
Universidade de Ribeirão Preto, Medicine (2024)
Universidade de Ribeirão Preto, Medicine (2024)
Pain and Addiction Interaction Neuroscience (PAIN) Lab
Publications Overview
- 32 Publications
- 106 Citations
- 19 Yale Co-Authors
About
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Titles
Postdoctoral Associate
Postdoctoral Associate, Psychiatry
Biography
Dr. Gabriel Costa is a Postdoctoral Associate in the Pain and Addiction Interactions Neuroscience (PAIN) Lab at Yale University, where his research focuses on addiction psychiatry, chronic pain medicine, and cannabinoid pharmacology. With a background in both medicine and engineering, he integrates clinical research methods with advanced data science approaches to explain clinical phenomena through mechanistic human laboratory studies.
His work aims to develop novel pharmacological interventions for individuals with co-occurring opioid use disorder and chronic pain, leveraging human experimental medicine, quantitative sensory testing, pharmacokinetic/pharmacodynamic modeling, and ecological momentary assessment. Through this multidisciplinary approach, Dr. Costa seeks to inform precision treatment strategies and advance the understanding of how cannabinoids and related compounds modulate pain and addiction processes.
Last Updated on September 10, 2025.
Appointments
Psychiatry
Postdoctoral AssociatePrimary
Other Departments & Organizations
- All Institutions
- Pain and Addiction Interaction Neurosciences (PAIN) Lab
- Psychiatry
Education & Training
- MD
- Universidade de Ribeirão Preto, Medicine (2024)
Research
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Overview
Public Health Interests
Clinical Trials; Behavioral Health; Mental Health; Statistical Computing; Randomized Trials; Substance Use, Addiction
ORCID
0009-0007-8702-5436- View Lab Website
Pain and Addiction Interaction Neuroscience (PAIN) Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Gabriel P. A. Costa's published research.
Joao P. De Aquino, MD
Julio Nunes, MD
Mehmet Sofuoglu, MD, PhD
Jeremy Weleff, DO
Ismene Petrakis, MD
Melissa C Funaro, MLS, MS
Publications
2026
Modulating the endocannabinoid system in alcohol use disorder: A translational systematic review and meta-analysis of preclinical and human studies
Costa G, Cerezo-Matias M, Funaro M, Bagdas D, Kaye A, Krystal J, Petrakis I, De Aquino J. Modulating the endocannabinoid system in alcohol use disorder: A translational systematic review and meta-analysis of preclinical and human studies. Molecular Psychiatry 2026, 1-23. PMID: 41760917, DOI: 10.1038/s41380-026-03523-5.Peer-Reviewed Original ResearchAltmetricConceptsAlcohol use disorderEndocannabinoid system modulationEndocannabinoid systemInverse agonistsUse disorderAlcohol use behaviorsHuman studiesConverging evidenceAffective processesCannabinoid receptorsMeta-analysesCannabidiolPharmacological treatmentNull effectMeta-analysisMethodological inconsistenciesUse behaviorsPreclinical evidenceSystematic reviewDose-response analysisAlcohol intakeAgonistsMechanism of actionPreclinical studiesDisordersCharacteristics of United States Food and Drug Administration Drug Recalls Involving Opioid Medications, 2002–2025
Nunes J, Costa G, De Aquino J. Characteristics of United States Food and Drug Administration Drug Recalls Involving Opioid Medications, 2002–2025. Pharmacoepidemiology And Drug Safety 2026, 35: e70341. PMID: 41725568, DOI: 10.1002/pds.70341.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsFood and Drug AdministrationUnited States Food and Drug AdministrationStates Food and Drug AdministrationChi-square testOpioid medicationsClass I-IIIInter-rater agreementDrug AdministrationClass IOpioidCohen's kIndependent reviewersMorphineMedication recallInter-RaterI-IIIHydromorphoneRecall reasonFentanylDelivery systemSeverityDescriptive analysisOxycodoneDrug recallHydrocodoneClinical Presentations and Treatment of Baclofen Toxicity and Withdrawal: A Systematic Review
Iqbal M, Modi P, Sehgal K, Costa G, Bhattacharya G, Nero N, Siddiqui J, Weleff J, Anand A. Clinical Presentations and Treatment of Baclofen Toxicity and Withdrawal: A Systematic Review. CNS Drugs 2026, 40: 419-449. PMID: 41555041, DOI: 10.1007/s40263-025-01254-9.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsClinical presentationCase reportBaclofen toxicityCase seriesMechanical ventilationJoanna Briggs Institute Critical Appraisal ChecklistObservational studySystematic reviewB receptor agonistOff-label dosesCritical Appraisal ChecklistCentral nervous system depressionLength of hospitalizationAlcohol use disorderRisk of biasNervous system depressionStandard clinical guidelinesIntrathecal baclofenAutonomic instabilityWithdrawal syndromePatient safetyPreclinical dataAppraisal ChecklistPrompt recognitionRetrospective study
2025
Exploring the effects of cannabidiol on pain sensitivity using quantitative sensory testing among individuals receiving methadone or buprenorphine for opioid use disorder: an open-label, proof-of-concept study
Costa G, Suh R, Sofuoglu M, De Aquino J. Exploring the effects of cannabidiol on pain sensitivity using quantitative sensory testing among individuals receiving methadone or buprenorphine for opioid use disorder: an open-label, proof-of-concept study. Addictive Behaviors Reports 2025, 23: 100654. PMID: 41496743, PMCID: PMC12767834, DOI: 10.1016/j.abrep.2025.100654.Peer-Reviewed Original ResearchAltmetricConceptsQuantitative sensory testingOpioid use disorderPain sensitivityUse disorderProof-of-concept studyCannabidiol's impactCBD doseOpen-labelChronic painPain managementQuantitative sensory testing measuresPlacebo-controlled randomized trialPain response patternsTolerability of cannabidiolHeat pain thresholdEffects of cannabidiolAdverse cognitive effectsOpioid use disorder treatmentSensory testingPain thresholdVerbal memorySubjective effectsCannabidiol doseAdverse eventsBuprenorphine groupDifferences in diagnosis and treatment across racial–ethnic groups with co-occurring chronic pain and opioid use disorder: a scoping review
Nunes J, Costa G, Cerezo-Matias M, Funaro M, Campbell C, De Aquino J. Differences in diagnosis and treatment across racial–ethnic groups with co-occurring chronic pain and opioid use disorder: a scoping review. Pain Medicine 2025, pnaf173. PMID: 41358971, DOI: 10.1093/pm/pnaf173.Peer-Reviewed Original ResearchConceptsChronic non-cancer painOpioid use disorderScoping ReviewMixed Methods Appraisal ToolNon-pharmacological pain treatmentsMethods Appraisal ToolNon-whitePatient-reported experiencesRisk of opioid misusePain-related distressOpioid use disorder diagnosisProvider decision-makingPRISMA-ScR guidelinesOpioid use disorder careOpioid prescribing ratesNon-cancer painRacial-ethnic differencesAccess-related factorsHigh riskUse disorderManagement of individualsRacial-ethnic groupsTreatment access barriersIntegrated careNon-white individualsExpanding Access to Buprenorphine and Methadone: Global Perspectives and Policy Recommendations
Nunes J, Costa G, De Aquino J, Adinoff B. Expanding Access to Buprenorphine and Methadone: Global Perspectives and Policy Recommendations. Substance Use & Addiction Journal 2025, 47: 595-610. PMID: 41317155, DOI: 10.1177/29767342251392342.Peer-Reviewed Original ResearchCitationsAltmetricConceptsNarrative review of peer-reviewedPolicy literaturePolicy recommendationsOverdose deathsUniversal coverageMOUD accessPolicyRegulatory reformPublic health systemNational scale-upEconomic gainsReview of peer-reviewedOpioid use disorderNarrative reviewGlobal burdenInternational evidenceU.S. coverageNational prevalence dataOpioid-related deathsCenters for Disease ControlHealth systemMortality dataRegulatory bottlenecksGlobal Burden of Disease StudyMainstream healthcareContingency management for unhealthy alcohol use: A systematic review and meta‐analysis
Alessi M, dos Santos Barbetta L, Andreata V, Leal A, Freitas R, Costa G, Nero N, Anand A. Contingency management for unhealthy alcohol use: A systematic review and meta‐analysis. Alcohol Clinical And Experimental Research 2025, 49: 2660-2674. PMID: 41261929, DOI: 10.1111/acer.70198.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsUnhealthy alcohol useAlcohol use disorderContingency managementAlcohol useSystematic reviewMeta-analysisUse disorderClinical utilityAlcohol consumptionGeneric inverse variance methodSevere alcohol use disorderTreatment of alcohol-related problemsMeasures of alcohol useSelf-reported alcohol consumptionNon-contingent rewardsInverse variance methodAlcohol-free daysTreatment-as-usualSubstance use disordersNon-randomized trialsROBINS-I toolAlcohol-related problemsRisk of biasEvidence-based approachConcurrent nicotineReadability, linguistic complexity, and stigma in ChatGPT responses to opioid use disorder FAQs: A comparative analysis
Campos V, Heringer D, Costa G, Oliva H, Anand A. Readability, linguistic complexity, and stigma in ChatGPT responses to opioid use disorder FAQs: A comparative analysis. American Journal On Addictions 2025 PMID: 41189042, DOI: 10.1111/ajad.70101.Peer-Reviewed Original Research135. Bridging Psychiatry and Endocrinology: A Case Report on Pheochromocytoma With Severe Medication Anxiety
Collins A, Heringer D, Costa G, Burns N. 135. Bridging Psychiatry and Endocrinology: A Case Report on Pheochromocytoma With Severe Medication Anxiety. Journal Of The Academy Of Consultation-Liaison Psychiatry 2025, 66: s115. DOI: 10.1016/j.jaclp.2025.10.137.Peer-Reviewed Original ResearchConceptsTobacco use Disorder and Chronic Pain: a Narrative Review of Integrated Treatment Approaches, Underlying Mechanisms, and Future Research Directions
da Rocha L, Costa G, Sofuoglu M, Castaldelli-Maia J, De Aquino J. Tobacco use Disorder and Chronic Pain: a Narrative Review of Integrated Treatment Approaches, Underlying Mechanisms, and Future Research Directions. Current Addiction Reports 2025, 12: 75. DOI: 10.1007/s40429-025-00687-y.Peer-Reviewed Original ResearchConceptsIntegrated treatment approachBrief motivational interventionChronic painEcological momentary assessmentEvidence-based careMethodological limitationsTobacco use disorderNarrative reviewHigh co-occurrenceTreatment approachesWell-powered randomized controlled trialsRandomized Controlled TrialsMomentary assessmentMood benefitsMotivational interventionUse disorderAdvanced careSmoking relapseOutcome expectationsTobacco useSmoking cessationPain managementPain-related stressEvidence baseFollow-up period
Academic Achievements & Community Involvement
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Honors
honor Early Career Investigator
04/07/2025National AwardCollege on Problems of Drug Dependencehonor John Renner Travel Award
01/07/2024National AwardAmerican Academy of Addiction Psychiatry
News & Links
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News
- February 27, 2026Source: Molecular Psychiatry
Modulating the Endocannabinoid System in Alcohol Use Disorder: A Translational Systematic Review and Meta-Analysis of Preclinical and Human Studies
- February 23, 2026
Yale Study Examines FDA Drug Recall Data Involving Opioid Medications
- January 12, 2026Source: Pain Medicine
Review: Differences in Diagnosis and Treatment Across Racial–Ethnic Groups with Co-Occurring Chronic Pain and Opioid Use Disorder
- December 02, 2025
Expanding Access to Buprenorphine and Methadone: Global Perspectives and Policy Recommendations
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