Gabriel P. A. Costa, MD
Postdoctoral AssociateDownloadHi-Res Photo
Cards
Education
MD
Universidade de Ribeirão Preto, Medicine (2024)
Universidade de Ribeirão Preto, Medicine (2024)
Pain and Addiction Interaction Neuroscience (PAIN) Lab
Publications Overview
- 33 Publications
- 155 Citations
- 21 Yale Co-Authors
Education
MD
Universidade de Ribeirão Preto, Medicine (2024)
Universidade de Ribeirão Preto, Medicine (2024)
Pain and Addiction Interaction Neuroscience (PAIN) Lab
Publications Overview
- 33 Publications
- 155 Citations
- 21 Yale Co-Authors
Education
MD
Universidade de Ribeirão Preto, Medicine (2024)
Universidade de Ribeirão Preto, Medicine (2024)
Pain and Addiction Interaction Neuroscience (PAIN) Lab
Publications Overview
- 33 Publications
- 155 Citations
- 21 Yale Co-Authors
About
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Titles
Postdoctoral Associate
Postdoctoral Associate, Psychiatry
Biography
Dr. Gabriel Costa is a Postdoctoral Associate in the Pain and Addiction Interactions Neuroscience (PAIN) Lab at Yale University, where his research focuses on addiction psychiatry, chronic pain medicine, and cannabinoid pharmacology. With a background in both medicine and engineering, he integrates clinical research methods with advanced data science approaches to explain clinical phenomena through mechanistic human laboratory studies.
His work aims to develop novel pharmacological interventions for individuals with co-occurring opioid use disorder and chronic pain, leveraging human experimental medicine, quantitative sensory testing, pharmacokinetic/pharmacodynamic modeling, and ecological momentary assessment. Through this multidisciplinary approach, Dr. Costa seeks to inform precision treatment strategies and advance the understanding of how cannabinoids and related compounds modulate pain and addiction processes.
Last Updated on September 10, 2025.
Appointments
Psychiatry
Postdoctoral AssociatePrimary
Other Departments & Organizations
- Pain and Addiction Interaction Neurosciences (PAIN) Lab
- Psychiatry
Education & Training
- MD
- Universidade de Ribeirão Preto, Medicine (2024)
Research
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Overview
Public Health Interests
Behavioral Health; Clinical Trials; Mental Health; Substance Use, Addiction; Randomized Trials; Statistical Computing
ORCID
0009-0007-8702-5436- View Lab Website
Pain and Addiction Interaction Neuroscience (PAIN) Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Gabriel P. A. Costa's published research.
Joao P. De Aquino, MD
Julio Nunes, MD
Mehmet Sofuoglu, MD, PhD
Jeremy Weleff, DO
Brian Pittman
Ismene Petrakis, MD
Publications
2026
Recent cannabis exposure and acute nicotine effects: insights from randomized, double-blind, placebo-controlled intravenous nicotine studies
Costa G, MacLean R, Sofuoglu M, De Aquino J. Recent cannabis exposure and acute nicotine effects: insights from randomized, double-blind, placebo-controlled intravenous nicotine studies. The International Journal Of Neuropsychopharmacology 2026, 29: pyag030. PMID: 42189934, PMCID: PMC13322297, DOI: 10.1093/ijnp/pyag030.Peer-Reviewed Original ResearchCitationsAn opioid-withholding human laboratory paradigm during opioid agonist treatment for opioid use disorder and chronic pain: Phase- and dose-dependent effects of cannabidiol
P. A. Costa G, Sofuoglu M, Compton P, Ranganathan M, Pittman B, De Aquino J. An opioid-withholding human laboratory paradigm during opioid agonist treatment for opioid use disorder and chronic pain: Phase- and dose-dependent effects of cannabidiol. Neuropsychopharmacology 2026, 1-10. PMID: 42162267, PMCID: PMC13213852, DOI: 10.1038/s41386-026-02443-w.Peer-Reviewed Original ResearchCitationsAltmetricBrief Report: Is once daily enough? Assessing the impact of timing of methadone dose on pain sensitivity via quantitative sensory testing in persons with opioid use disorder
Costa G, Riggione C, Meyerovich J, Barry D, De Aquino J. Brief Report: Is once daily enough? Assessing the impact of timing of methadone dose on pain sensitivity via quantitative sensory testing in persons with opioid use disorder. American Journal On Addictions 2026 PMID: 42046174, PMCID: PMC13132031, DOI: 10.1111/ajad.70162.Peer-Reviewed Original ResearchAltmetricModulating the endocannabinoid system in alcohol use disorder: A translational systematic review and meta-analysis of preclinical and human studies
Costa G, Cerezo-Matias M, Funaro M, Bagdas D, Kaye A, Krystal J, Petrakis I, De Aquino J. Modulating the endocannabinoid system in alcohol use disorder: A translational systematic review and meta-analysis of preclinical and human studies. Molecular Psychiatry 2026, 31: 3849-3871. PMID: 41760917, PMCID: PMC13269127, DOI: 10.1038/s41380-026-03523-5.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsThis study investigates targeting the endocannabinoid system for alcohol use disorder, finding promising preclinical results for cannabidiol and CB1 receptor modulators, but inconsistent human trial outcomes highlight the need for better-designed clinical studies.Characteristics of United States Food and Drug Administration Drug Recalls Involving Opioid Medications, 2002–2025
Nunes J, Costa G, De Aquino J. Characteristics of United States Food and Drug Administration Drug Recalls Involving Opioid Medications, 2002–2025. Pharmacoepidemiology And Drug Safety 2026, 35: e70341. PMID: 41725568, DOI: 10.1002/pds.70341.Peer-Reviewed Original ResearchClinical Presentations and Treatment of Baclofen Toxicity and Withdrawal: A Systematic Review
Iqbal M, Modi P, Sehgal K, Costa G, Bhattacharya G, Nero N, Siddiqui J, Weleff J, Anand A. Clinical Presentations and Treatment of Baclofen Toxicity and Withdrawal: A Systematic Review. CNS Drugs 2026, 40: 419-449. PMID: 41555041, DOI: 10.1007/s40263-025-01254-9.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
2025
Exploring the effects of cannabidiol on pain sensitivity using quantitative sensory testing among individuals receiving methadone or buprenorphine for opioid use disorder: an open-label, proof-of-concept study
Costa G, Suh R, Sofuoglu M, De Aquino J. Exploring the effects of cannabidiol on pain sensitivity using quantitative sensory testing among individuals receiving methadone or buprenorphine for opioid use disorder: an open-label, proof-of-concept study. Addictive Behaviors Reports 2025, 23: 100654. PMID: 41496743, PMCID: PMC12767834, DOI: 10.1016/j.abrep.2025.100654.Peer-Reviewed Original ResearchCitationsAltmetricDifferences in diagnosis and treatment across racial–ethnic groups with co-occurring chronic pain and opioid use disorder: a scoping review
Nunes J, Costa G, Cerezo-Matias M, Funaro M, Campbell C, De Aquino J. Differences in diagnosis and treatment across racial–ethnic groups with co-occurring chronic pain and opioid use disorder: a scoping review. Pain Medicine 2025, 27: 613-626. PMID: 41358971, DOI: 10.1093/pm/pnaf173.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsExpanding Access to Buprenorphine and Methadone: Global Perspectives and Policy Recommendations
Nunes J, Costa G, De Aquino J, Adinoff B. Expanding Access to Buprenorphine and Methadone: Global Perspectives and Policy Recommendations. Substance Use & Addiction Journal 2025, 47: 595-610. PMID: 41317155, DOI: 10.1177/29767342251392342.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricContingency management for unhealthy alcohol use: A systematic review and meta‐analysis
Alessi M, dos Santos Barbetta L, Andreata V, Leal A, Freitas R, Costa G, Nero N, Anand A. Contingency management for unhealthy alcohol use: A systematic review and meta‐analysis. Alcohol Clinical And Experimental Research 2025, 49: 2660-2674. PMID: 41261929, DOI: 10.1111/acer.70198.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
Academic Achievements & Community Involvement
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Honors
honor Near-Peer Mentorship Program – Mentee Award
08/06/2026National AwardAmerican College of Neuropsychopharmacology (ACNP)honor Early Career Investigator
04/07/2025National AwardCollege on Problems of Drug Dependencehonor John Renner Travel Award
01/07/2024National AwardAmerican Academy of Addiction Psychiatry
News & Links
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News
- August 11, 2026
Costa, Oliva Chosen for 2027 ACNP Near-Peer Mentorship Program
- May 21, 2026Source: Neuropsychopharmacology
An Opioid-Withholding Human Laboratory Paradigm During Opioid Agonist Treatment for Opioid Use Disorder and Chronic Pain: Phase- and Dose-Dependent Effects of Cannabidiol
- February 27, 2026Source: Molecular Psychiatry
Modulating the Endocannabinoid System in Alcohol Use Disorder: A Translational Systematic Review and Meta-Analysis of Preclinical and Human Studies
- February 23, 2026
Yale Study Examines FDA Drug Recall Data Involving Opioid Medications
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