Gabriel P. A. Costa, MD
Postdoctoral AssociateDownloadHi-Res Photo
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Education
MD
Universidade de Ribeirão Preto, Medicine (2024)
Universidade de Ribeirão Preto, Medicine (2024)
Pain and Addiction Interaction Neuroscience (PAIN) Lab
Publications Overview
- 22 Publications
- 71 Citations
- 16 Yale Co-Authors
Education
MD
Universidade de Ribeirão Preto, Medicine (2024)
Universidade de Ribeirão Preto, Medicine (2024)
Pain and Addiction Interaction Neuroscience (PAIN) Lab
Publications Overview
- 22 Publications
- 71 Citations
- 16 Yale Co-Authors
Education
MD
Universidade de Ribeirão Preto, Medicine (2024)
Universidade de Ribeirão Preto, Medicine (2024)
Pain and Addiction Interaction Neuroscience (PAIN) Lab
Publications Overview
- 22 Publications
- 71 Citations
- 16 Yale Co-Authors
About
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Titles
Postdoctoral Associate
Postdoctoral Associate, Psychiatry
Biography
Dr. Gabriel Costa is a Postdoctoral Associate in the Pain and Addiction Interactions Neuroscience (PAIN) Lab at Yale University, where his research focuses on addiction psychiatry, chronic pain medicine, and cannabinoid pharmacology. With a background in both medicine and engineering, he integrates clinical research methods with advanced data science approaches to explain clinical phenomena through mechanistic human laboratory studies.
His work aims to develop novel pharmacological interventions for individuals with co-occurring opioid use disorder and chronic pain, leveraging human experimental medicine, quantitative sensory testing, pharmacokinetic/pharmacodynamic modeling, and ecological momentary assessment. Through this multidisciplinary approach, Dr. Costa seeks to inform precision treatment strategies and advance the understanding of how cannabinoids and related compounds modulate pain and addiction processes.
Last Updated on September 10, 2025.
Appointments
Psychiatry
Postdoctoral AssociatePrimary
Other Departments & Organizations
- Pain and Addiction Interaction Neurosciences (PAIN) Lab
- Psychiatry
Education & Training
- MD
- Universidade de Ribeirão Preto, Medicine (2024)
Research
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Overview
Public Health Interests
Behavioral Health; Clinical Trials; Mental Health; Randomized Trials; Statistical Computing; Substance Use, Addiction
ORCID
0009-0007-8702-5436- View Lab Website
Pain and Addiction Interaction Neuroscience (PAIN) Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Gabriel P. A. Costa's published research.
Joao P. De Aquino, MD
Julio Nunes, MD
Mehmet Sofuoglu, MD, PhD
Jeremy Weleff, DO
Brian Pittman
Ismene Petrakis, MD
Publications
2025
Readability, linguistic complexity, and stigma in ChatGPT responses to opioid use disorder FAQs: A comparative analysis
Campos V, Heringer D, Costa G, Oliva H, Anand A. Readability, linguistic complexity, and stigma in ChatGPT responses to opioid use disorder FAQs: A comparative analysis. American Journal On Addictions 2025 PMID: 41189042, DOI: 10.1111/ajad.70101.Peer-Reviewed Original ResearchTobacco–cannabis co‐use in adults ≥50: Trends, medical marijuana laws, and cessation implications—Letter to the Editor
Costa G, Asnes S, De Aquino J. Tobacco–cannabis co‐use in adults ≥50: Trends, medical marijuana laws, and cessation implications—Letter to the Editor. American Journal On Addictions 2025 PMID: 41025258, DOI: 10.1111/ajad.70088.Peer-Reviewed Original ResearchQuantitative sensory testing of pain in persons with opioid use disorder on opioid agonist treatment: a scoping review
Oliveira D, Costa G, Fontenele R, Córdoba-Delgado M, Funaro M, Campbell C, Fiellin D, Angarita G, De Aquino J. Quantitative sensory testing of pain in persons with opioid use disorder on opioid agonist treatment: a scoping review. Pain Medicine 2025, pnaf132. PMID: 40990827, DOI: 10.1093/pm/pnaf132.Peer-Reviewed Original ResearchConceptsQuantitative sensory testingOpioid use disorderOpioid agonist treatmentQST measuresAgonist treatmentQuantitative sensory testing methodologyQuantitative sensory testing outcomesUse disorderNon-OAT opioidsPain processing abnormalitiesPain sensitivity changesPain-related outcomesCold pain toleranceCentral sensitizationSystematic literature searchPain mechanismsPain modulationNeuroadaptive changesPain responseChronic painTreatment responseProlonged abstinencePainWeb of ScienceOpioidImpact of X-Waiver Elimination on Post-Hospital Discharge Buprenorphine Prescribing: An Interrupted Time Series Analysis.
Wang PR, Mascha EJ, Li Y, Bobak L, Dorney I, Costa G, Barnett B, Anand A. Impact of X-Waiver Elimination on Post-Hospital Discharge Buprenorphine Prescribing: An Interrupted Time Series Analysis. J Addict Med 2025 PMID: 40794490, DOI: 10.1097/ADM.0000000000001568.Peer-Reviewed Original ResearchCannabis use frequency is associated with emotion dysregulation among persons receiving long-term opioid therapy for chronic pain: A psychophysiological study
De Aquino J, Costa G, Nunes J, Hudak J, Odette M, Garland E. Cannabis use frequency is associated with emotion dysregulation among persons receiving long-term opioid therapy for chronic pain: A psychophysiological study. Drug And Alcohol Dependence 2025, 275: 112812. PMID: 40779835, PMCID: PMC12396927, DOI: 10.1016/j.drugalcdep.2025.112812.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsEmotion regulation capacitiesLong-term opioid therapyCannabis use frequencySkin conductance responsesFrequent cannabis useCannabis useChronic painPain severityEmotion dysregulationCognitive reappraisalOpioid therapyAssociated with more frequent cannabis useReappraisal of negative stimuliAssociated with emotion dysregulationRegulation capacityPatterns of cannabis useHeavy cannabis useEmotion regulation interventionAssociated with more daysBrief Pain InventoryNegative stimuliPassive viewingCorrugator electromyographyPsychophysiological measuresConductance responsesThe Role of Childhood Trauma in Chronic Pain and Substance Use Among Individuals Receiving Methadone Treatment for Opioid Use Disorder.
Costa G, Ra J, Meyerovich J, Pittman B, C Nunes J, De Aquino J. The Role of Childhood Trauma in Chronic Pain and Substance Use Among Individuals Receiving Methadone Treatment for Opioid Use Disorder. Journal Of Addiction Medicine 2025 PMID: 40728216, DOI: 10.1097/adm.0000000000001553.Peer-Reviewed Original ResearchConceptsOpioid use disorderChildhood Trauma QuestionnaireChildhood traumaSubstance useCannabis initiationUse disorderBrief Pain InventoryEmotional abuseAge of cannabis initiationPain severityChronic painHigher childhood trauma scoresHistory of childhood traumaLikelihood of cannabis useLevels of emotional abuseChildhood trauma exposureChildhood trauma scoresTrauma-focused assessmentAlcohol consumptionHigher alcohol useOpioid use disorder treatment programsTrauma exposureTrauma QuestionnaireCannabis useTrauma subscalesPain interference, alcohol use, and metabolic health: Insights from a nationally representative study
Costa G, Suh R, Nunes J, Pittman B, Sofuoglu M, Petrakis I, De Aquino J. Pain interference, alcohol use, and metabolic health: Insights from a nationally representative study. Alcohol Clinical And Experimental Research 2025, 49: 1768-1777. PMID: 40568749, DOI: 10.1111/acer.70108.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNational Health and Nutrition Examination SurveyPain interferenceHeavy alcohol useAlcohol usePhysical activityHealth and Nutrition Examination SurveyMetabolic dysfunctionSleep durationNutrition Examination SurveyQuasi-Poisson regression modelCross-sectional analysisTherapeutic approachesComplex patient populationHours of sleepExamination SurveyUS adultsPrimary exposureSecondary analysisChronic painMetabolic healthInteractive associationsClinical outcomesPathophysiological domainsHigher TyGPatient populationPharmacotherapies for Binge Eating Disorder: Systematic Review and Network Meta‐Analysis
Costa G, Assunção B, Belfort‐DeAguiar R, Nunes J. Pharmacotherapies for Binge Eating Disorder: Systematic Review and Network Meta‐Analysis. Obesity Reviews 2025, 26: e13936. PMID: 40344489, DOI: 10.1111/obr.13936.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsBinge Eating DisorderTolerability of pharmacological interventionsBinge-eating episode frequencyEating disorder scoresMedication discontinuation ratesOverall effect sizePharmacological treatment optionsBinge-eating episodesCompulsive overeatingPsychiatric diagnosisDisorder scoresEpisode frequencyLisdexamfetamineAssessment instrumentsRecurrent episodesEffect sizeAdverse eventsPhysical healthDasotralineDiscontinuation ratesRemission rateDerSimonian-Laird random-effects modelPharmacological interventionsLandscape of pharmacotherapyBingeLetter to the Editor: Effect of Nicotine Replacement Therapy on Perioperative Pain Management and Opioid Requirement in Abstinent Tobacco Smokers Undergoing Spinal Fusion: A Double-Blind Randomized Controlled Trial
Costa G, De Aquino J. Letter to the Editor: Effect of Nicotine Replacement Therapy on Perioperative Pain Management and Opioid Requirement in Abstinent Tobacco Smokers Undergoing Spinal Fusion: A Double-Blind Randomized Controlled Trial. Journal Of Neurosurgical Anesthesiology 2025, 37: 418-419. PMID: 40325556, DOI: 10.1097/ana.0000000000001041.Peer-Reviewed Original Research522 The Bidirectional Relationship Between Pain and Tobacco Use: Insights From The Population Assessment of Tobacco and Health Study
Costa G, Nunes J, Suh R, Sofuoglu M, De Aquino J. 522 The Bidirectional Relationship Between Pain and Tobacco Use: Insights From The Population Assessment of Tobacco and Health Study. Journal Of Pain 2025, 29: 105320. DOI: 10.1016/j.jpain.2025.105320.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
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Honors
honor Early Career Investigator
04/07/2025National AwardCollege on Problems of Drug Dependencehonor John Renner Travel Award
01/07/2024National AwardAmerican Academy of Addiction Psychiatry
News & Links
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News
- December 02, 2025
Expanding Access to Buprenorphine and Methadone: Global Perspectives and Policy Recommendations
- October 15, 2025Source: Current Addiction Reports
Tobacco Use Disorder and Chronic Pain: A Narrative Review of Integrated Treatment Approaches, Underlying Mechanisms, and Future Research Directions
- September 25, 2025Source: Pain Medicine
Quantitative Sensory Testing of Pain in Persons with Opioid Use Disorder on Opioid Agonist Treatment: A Scoping Review
- August 11, 2025Source: Drug and Alcohol Dependence
Cannabis Use Frequency is Associated with Emotion Dysregulation Among Persons Receiving Long-Term Opioid Therapy for Chronic Pain
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