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2014
Disruption of TGF-β signaling in smooth muscle cell prevents flow-induced vascular remodeling
Gao F, Chambon P, Tellides G, Kong W, Zhang X, Li W. Disruption of TGF-β signaling in smooth muscle cell prevents flow-induced vascular remodeling. Biochemical And Biophysical Research Communications 2014, 454: 245-250. PMID: 25451249, DOI: 10.1016/j.bbrc.2014.10.092.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH KeywordsAnimalsCarotid ArteriesCell ProliferationHemodynamicsMacrophagesMaleMatrix Metalloproteinase 9MiceMice, Inbred C57BLMice, KnockoutMyocytes, Smooth MuscleProtein Serine-Threonine KinasesReceptor, Transforming Growth Factor-beta Type IIReceptors, Transforming Growth Factor betaSignal TransductionTransforming Growth Factor betaVascular RemodelingConceptsFlow-induced vascular remodelingSmooth muscle cellsVascular remodelingTGF-β signalingCarotid arteryMatrix metalloproteinaseLeft common carotid arteryPrincipal resident cellsProliferation of SMCsInfiltration of macrophagesCommon carotid arteryExpression of TGFBR2Deletion mouse modelTGF-β pathwayArterial remodelingPartial ligationMouse modelBackground miceResident cellsMuscle cellsArterial wallProminent inhibitionMiceCarotid mediaRemodelingDisruption of TGF-β signaling in smooth muscle cell prevents elastase-induced abdominal aortic aneurysm
Gao F, Chambon P, Offermanns S, Tellides G, Kong W, Zhang X, Li W. Disruption of TGF-β signaling in smooth muscle cell prevents elastase-induced abdominal aortic aneurysm. Biochemical And Biophysical Research Communications 2014, 454: 137-143. PMID: 25450370, DOI: 10.1016/j.bbrc.2014.10.053.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH KeywordsAnimalsAortic Aneurysm, AbdominalDisease Models, AnimalHeterozygoteMacrophagesMaleMatrix Metalloproteinase 9MiceMice, Inbred C57BLMice, KnockoutMyocytes, Smooth MusclePancreatic ElastaseProtein Serine-Threonine KinasesReceptor, Transforming Growth Factor-beta Type IIReceptors, Transforming Growth Factor betaSignal TransductionTransforming Growth Factor betaUp-RegulationConceptsAbdominal aortic aneurysmSmooth muscle cellsTGF-β pathwayAortic aneurysmElastase-induced abdominal aortic aneurysmMedial SMC lossPrincipal resident cellsFormation of AAAVascular smooth muscle cellsExpression of TGFBR2Matrix metalloproteinases (MMPs) expressionPathogenesis of aneurysmsTGF-β signalingAAA inductionMacrophage infiltrationAAA formationAneurysm formationSMC lossAAA pathogenesisBackground miceMetalloproteinases expressionAnimal modelsAortic wallResident cellsMuscle cells
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