Felipe Larios, MD
Postdoctoral AssociateAbout
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Postdoctoral Associate
Biography
Dr. Larios is a Postdoctoral Associate in the Section of General Internal Medicine at Yale School of Medicine, where he conducts research under the mentorship of Drs. Alissa Chen and Kasia Lipska. His work focuses on improving the quality, safety, and equity of care for patients with chronic endocrine and metabolic diseases through the use of large-scale clinical data and real-world evidence.
Trained as a physician in Lima, Peru, he developed an early interest in academic medicine and in using health services research and clinical epidemiology to address questions that directly impact healthcare delivery. He is particularly interested in generating evidence that supports thoughtful, patient-centered longitudinal care for people living with chronic conditions. Prior to joining Yale, he was a Research Fellow in the Knowledge and Evaluation Research Unit at Mayo Clinic, where he applied AI-enabled methods to investigate thyroid cancer overdiagnosis and overtreatment.
At Yale, Dr. Larios studies obesity and diabetes outcomes, with a particular focus on patient-reported and clinical outcomes associated with GLP-1 receptor agonist therapies in older adults, as well as insulin affordability and rationing following the Inflation Reduction Act. He plans to pursue a career as an academic endocrinologist, combining patient care with collaborative research that advances evidence-based care and improves the lives of people living with chronic disease.
Departments & Organizations
Education & Training
- Research Fellowship
- Mayo Clinic (2026)
- MD
- Universidad Peruana Cayetano Heredia (2023)
Research
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Overview
Medical Research Interests
Public Health Interests
ORCID
0009-0005-9790-566X
Research at a Glance
Publications Timeline
Research Interests
Thyroid Nodule
Delivery of Health Care
Publications
Featured Publications
Artificial intelligence-enabled analysis of radiology reports: epidemiology and outcomes of incidental thyroid findings
Larios F, Borras-Osorio M, Wu Y, Claros A, Toro-Tobon D, Cabezas E, Loor-Torres R, Chavez M, Maldonado K, Andrango L, Jimenez M, Alzamora I, Al Zahidy M, Montero M, Proano A, Jacome C, Fan J, Ponce-Ponte O, Branda M, Ospina N, Brito J. Artificial intelligence-enabled analysis of radiology reports: epidemiology and outcomes of incidental thyroid findings. The Journal Of Clinical Endocrinology & Metabolism 2026, dgag186. PMID: 42037237, DOI: 10.1210/clinem/dgag186.Peer-Reviewed Original ResearchAltmetricConceptsIncidental thyroid findingsHigher oddsThyroid findingsThyroid cancer diagnosisLow-risk cancersEmergency medicineOlder adultsHigher BMINuclear medicine scansCancer diagnosisNodule characteristicsLogistic regressionNeck CTThyroid nodule diagnosisChest CTClinical outcomesThyroid diseaseImaging ReportingFollow-upBody regionsRadiology reportsPrevalenceAdultsNatural language processing pipelineThyroidThe “care” in healthcare: from efficient processing to human responsiveness
Larios F, Randall L, Hargraves I, Gionfriddo M, Montori V. The “care” in healthcare: from efficient processing to human responsiveness. Primary Dental Journal 2025, 14: 53-56. PMID: 41378789, DOI: 10.1177/20501684251394067.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsFactors and Outcomes of Inappropriate Thyroid Ultrasonography
Larios F, Toro-Tobon D, Jacome C, Ponce-Ponte O, Maldonado K, Andrango L, Proano A, Fan J, Loor-Torres R, Al Zahidy M, Claros A, Mulanovich K, Cabezas E, Wu Y, Branda M, Bischoff L, Ospina N, Brito J. Factors and Outcomes of Inappropriate Thyroid Ultrasonography. JAMA Otolaryngology - Head & Neck Surgery 2025, 151: 843-852. PMID: 40773204, PMCID: PMC12332758, DOI: 10.1001/jamaoto.2025.2049.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsThyroid ultrasonographyCohort studyPotential patient harmIn-person appointmentsThyroid cancer incidenceThyroid cancer casesThyroid cancerThyroid nodulesBaseline characteristicsBody mass indexClinical outcomesThyroid cancer diagnosisPatient harmCancer incidenceRetrospective cohort studyClinical encountersBaseline characteristics of patientsMain OutcomesCancer casesIn-personCancer diagnosisPapillary thyroid cancerCharacteristics of patientsClinical sitesDetection of thyroid nodulesIs Unplanned Excision of Soft Tissue Sarcomas Associated with Worse Oncological Outcomes?—A Systematic Review and Meta-Analysis
Larios F, Gonzalez M, Ruiz-Arellanos K, Silva G, Pretell-Mazzini J. Is Unplanned Excision of Soft Tissue Sarcomas Associated with Worse Oncological Outcomes?—A Systematic Review and Meta-Analysis. Cancers 2024, 16: 443. PMID: 38275885, PMCID: PMC10814439, DOI: 10.3390/cancers16020443.Peer-Reviewed Original ResearchCitationsConceptsFive-year LRFSUnplanned excisionSoft tissue sarcomasTumor bedSurgery ratesTissue sarcomasUnplanned excisions of soft tissue sarcomasPresence of residual diseaseGroup of rare neoplasmsExcision of soft tissue sarcomasAssociated with worse outcomesTumor bed excisionFive-year OSAmputation rateResidual diseaseResidual tumorOncological outcomesLocal recurrenceHigher amputation rateRare neoplasmsWorse outcomesLRFSBenign massesRisk ratioTumor
2025
Evaluating the Total Healthcare Cost of Inappropriately Ordered Thyroid Ultrasounds
Toro-Tobon D, Thao V, Borah B, Jacome C, Larios F, Guevara K, Andrango L, Proano A, Fan J, Loor-Torres R, Al Zahidy M, Cabezas E, Wu Y, Branda M, Ospina N, Brito J. Evaluating the Total Healthcare Cost of Inappropriately Ordered Thyroid Ultrasounds. Journal Of The Endocrine Society 2025, 9: bvaf143. PMID: 40980541, PMCID: PMC12448871, DOI: 10.1210/jendso/bvaf143.Peer-Reviewed Original ResearchCitationsAltmetricConceptsTotal healthcare costsHealthcare costsProcedural costsYears of follow-upRetrospective cohort studyMayo Clinic sitesThyroid cancer diagnosisUS healthcare costsCost-saving interventionThyroid ultrasoundAdult patientsFollow-upCohort studyPrimary outcomeSecondary analysisClinical sitesPatientsCancer diagnosisNatural language processing algorithmsCost reduction strategiesHealthcareLanguage processing algorithmsTotal costThyroidectomyBiopsyIn insulin-naive T2D, weekly efsitora was noninferior to daily degludec for reducing HbA1c at 52 wk.
Larios F, Gionfriddo M, Montori V. In insulin-naive T2D, weekly efsitora was noninferior to daily degludec for reducing HbA1c at 52 wk. Annals Of Internal Medicine 2025, 178: jc10. PMID: 39761579, DOI: 10.7326/annals-24-03438-jc.Peer-Reviewed Original ResearchAltmetricIn T1D, weekly efsitora was noninferior to daily degludec for reducing HbA1c but increased severe hypoglycemia at 26 wk.
Larios F, Gionfriddo M, Montori V. In T1D, weekly efsitora was noninferior to daily degludec for reducing HbA1c but increased severe hypoglycemia at 26 wk. Annals Of Internal Medicine 2025, 178: jc11. PMID: 39761586, DOI: 10.7326/annals-24-03440-jc.Peer-Reviewed Original Research
2024
What Are the Research Highlights of Periprosthetic Joint Infections From the 100 Most Cited Studies?
Gonzalez M, Acosta J, Davis J, Larios F, Olsen A, Chen A. What Are the Research Highlights of Periprosthetic Joint Infections From the 100 Most Cited Studies? Arthroplasty Today 2024, 30: 101564. PMID: 39559547, PMCID: PMC11570763, DOI: 10.1016/j.artd.2024.101564.Peer-Reviewed Original ResearchCitationsConceptsCitation countsMedian citation numberPublication yearCitation numberJournal of publicationPeriprosthetic joint infectionWeb of Science databasesLoE IIJoint infectionCitationsOrthopaedic journalsResearch highlightsPeriprosthetic joint infection patientsDefinition of periprosthetic joint infectionScience databasesRandomized Controlled TrialsWebCohort studyPeriprosthetic joint infection definitionsCited studiesTotal joint arthroplastyControlled TrialsJournalsFoot and Ankle Soft Tissue Sarcomas – Treatment and Oncologic Outcomes: A Systematic Review of the Literature
Fanfan D, Alvarez J, Shae J, Gonzalez M, Larios F, Pretell-Mazzini J. Foot and Ankle Soft Tissue Sarcomas – Treatment and Oncologic Outcomes: A Systematic Review of the Literature. Foot & Ankle Orthopaedics 2024, 9: 2473011424s00296. PMCID: PMC11686739, DOI: 10.1177/2473011424s00296.Peer-Reviewed Original ResearchConceptsSystematic reviewRisk factorsHigh riskDisease-specific survivalSoft tissue sarcomasAssociated with poor disease-specific survivalPoor disease-specific survivalAssociated with higher riskDisease-specific deathQuality appraisalSTROBE guidelinesLocal recurrenceAnklePositive marginsPRISMA guidelinesUnplanned excisionTissue sarcomasHigh risk of local recurrenceAmputationRisk of local recurrenceSoft tissue sarcoma treatmentFootHigh-grade tumorsType of surgeryRiskUse of computer-assisted hexapod external fixators for complex foot and ankle reconstructions – An analysis of functional outcomes and complications
Larios F, Gonzalez M, Ruiz-Arellanos K, Inchaustegui M, Pretell-Mazzini J, de la Blanca J. Use of computer-assisted hexapod external fixators for complex foot and ankle reconstructions – An analysis of functional outcomes and complications. Foot And Ankle Surgery 2024, 31: 153-159. PMID: 39245585, DOI: 10.1016/j.fas.2024.08.010.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAmerican Orthopaedic Foot and Ankle ScoreComplex footExternal fixationQuality of life outcomesShort Form SurveyTaylor Spatial FrameQuality-of-life outcomesPreoperative scoresHexapod external fixatorAnkle conditionsAnkle pathologyAnkle ScoreAnkle deformityScoring domainsTL-HEXTrueLok-HexAnkle reconstructionAnklePost-operative complicationsPrimary outcomeCircular external fixatorPost-operative improvementLife outcomesAnalysis of functional outcomesExternal fixation frame
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