Felicia A. Hardi
Wu Tsai Postdoc. Assoc. in Psych & PsychiatryAbout
Research
Publications
2025
Trauma-predictive brain network connectivity adaptively responds to mild acute stress
Hardi F, Ye J, Zhou I, Bai Z, Nguyen D, Loetscher K, Pratt J, Harris B, Gee D, Goldfarb E. Trauma-predictive brain network connectivity adaptively responds to mild acute stress. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2505965122. PMID: 40737323, PMCID: PMC12327799, DOI: 10.1073/pnas.2505965122.Peer-Reviewed Original ResearchConceptsBrain networksTrauma exposureAcute stressCommunity sampleConnectome-based predictive modelingCommunity sample of adultsAssociated with lower depressive symptomsMedial frontal cortexSalience network connectivityDefault mode networkMild acute stressLower depressive symptomsConnectivity of brain networksBrain network connectivityStress-exposed groupsSample of adultsSubsample of participantsFunctional connectivity networksRelative to controlsSalience networkFrontal cortexMode networkDepressive symptomsTraumatic experiencesMotor regions133. Trauma-Predictive Brain Networks Dynamically Respond to Acute Stress
Hardi F, Ye J, Zhou I, Bai Z, Nguyen D, Loetscher K, Pratt J, Gee D, Goldfarb E. 133. Trauma-Predictive Brain Networks Dynamically Respond to Acute Stress. Biological Psychiatry 2025, 97: s150. DOI: 10.1016/j.biopsych.2025.02.370.Peer-Reviewed Original Research
2024
Developmental Timing of Associations Among Parenting, Brain Architecture, and Mental Health
Michael C, Gard A, Tillem S, Hardi F, Dunn E, Smith A, McLoyd V, Brooks-Gunn J, Mitchell C, Monk C, Hyde L. Developmental Timing of Associations Among Parenting, Brain Architecture, and Mental Health. JAMA Pediatrics 2024, 178: 1326-1336. PMID: 39466276, PMCID: PMC11581745, DOI: 10.1001/jamapediatrics.2024.4376.Peer-Reviewed Original ResearchConceptsParental psychological aggressionWarm parentingMiddle childhoodMental healthLate childhoodBrain architectureAssociated with mental healthPsychological aggressionLongitudinal birth cohort studyHarsh parentingLong-term health outcomesNeural associationsAssociated with reduced anxietyEarly adulthoodFunctional magnetic resonance imagingYouth-reported anxietyDevelopmental timing of exposureAssociated with brain developmentHealth outcomesMental illnessPopulation-basedMain OutcomesEarly childhoodCumulative associationDepressive symptomsMother–child closeness and adolescent structural neural networks: a prospective longitudinal study of low-income families
Hong S, Hardi F, Tillem S, Goetschius L, Brooks-Gunn J, McLoyd V, Lopez-Duran N, Mitchell C, Hyde L, Monk C. Mother–child closeness and adolescent structural neural networks: a prospective longitudinal study of low-income families. Social Cognitive And Affective Neuroscience 2024, 19: nsae083. PMID: 39512200, PMCID: PMC11631430, DOI: 10.1093/scan/nsae083.Peer-Reviewed Original ResearchConceptsMother-child closenessLow-income familiesStudy of low-income familiesWhite matter organizationAged 9Increased global efficiencyPositive youth developmentChild reportsBrain organizationProspective longitudinal studyMatter organizationLongitudinal sampleAffectionate bondYouth developmentNeural pathwaysGlobal efficiencyConnectional organizationStructural networkChildrenChildhood adversity and adolescent mental health: Examining cumulative and specificity effects across contexts and developmental timing.
Hardi F, Peckins M, Mitchell C, McLoyd V, Brooks-Gunn J, Hyde L, Monk C. Childhood adversity and adolescent mental health: Examining cumulative and specificity effects across contexts and developmental timing. Development And Psychopathology 2024, 37: 1954-1970. PMID: 39359017, PMCID: PMC11965435, DOI: 10.1017/s0954579424001512.Peer-Reviewed Original ResearchYouth psychopathologyChildhood adversityPredictive of internalizing symptomsPredictors of internalizing symptomsImpact of childhood adversityFuture of familiesTiming of adversityAdolescent mental healthPsychological aggressionExternalizing symptomsMiddle childhoodParenting stressPsychopathologyLongitudinal sampleStructured life course modeling approachMental healthAdversityAged 9Early childhoodSpecific effectsAged 3ChildhoodSymptomsYouthToddlerhoodLatent Profiles of Childhood Adversity, Adolescent Mental Health, and Neural Network Connectivity
Hardi F, Beltz A, McLoyd V, Brooks-Gunn J, Huntley E, Mitchell C, Hyde L, Monk C. Latent Profiles of Childhood Adversity, Adolescent Mental Health, and Neural Network Connectivity. JAMA Network Open 2024, 7: e2430711. PMID: 39196556, PMCID: PMC11358864, DOI: 10.1001/jamanetworkopen.2024.30711.Peer-Reviewed Original ResearchConceptsMental healthAdolescent mental healthHigh adversityPopulation-based birth cohortChildhood adversityMultiple adversitiesAged 0 to 9 yearsMaternal mental healthAdverse childhood experiencesMultiple risk factorsAdverse profilePsychiatric morbidityMain OutcomesAdverse levelsBirth cohortSalience networkFrontoparietal networkHigher symptomsYouth-report measureCohort studyBrain healthLatent profilesLow adversityBrain connectivityChildhood experiencesData-driven, generalizable prediction of adolescent sleep disturbances in the multisite Adolescent Brain Cognitive Development Study
McCurry K, Toda-Thorne K, Taxali A, Angstadt M, Hardi F, Heitzeg M, Sripada C. Data-driven, generalizable prediction of adolescent sleep disturbances in the multisite Adolescent Brain Cognitive Development Study. Sleep 2024, 47: zsae048. PMID: 38366843, PMCID: PMC11168765, DOI: 10.1093/sleep/zsae048.Peer-Reviewed Original ResearchConceptsAdolescent Brain Cognitive DevelopmentSleep disturbanceAdolescent Brain Cognitive Development StudyDomains of psychopathologyHost of negative outcomesCognitive Development StudyCanonical correlation analysisAdolescent sleep disturbancesNon-parametric permutation testEarly adolescenceCognitive developmentNegative outcomesFollow-up dataDemographic variablesAdolescentsCanonical correlationSleepExcessive daytime somnolenceParticipantsAfrican American/Black raceDevelopment studiesDaytime somnolenceDemographic factorsCorrelation analysisSleep breathing disorders
2023
Poverty, Brain Development, and Mental Health: Progress, Challenges, and Paths Forward
Monk C, Hardi F. Poverty, Brain Development, and Mental Health: Progress, Challenges, and Paths Forward. Annual Review Of Developmental Psychology 2023, 5: 309-330. DOI: 10.1146/annurev-devpsych-011922-012402.Peer-Reviewed Original ResearchNeuroscience modelsNeuroimaging findingsIntervention researchEffect sizeMental healthBrain developmentInterpretation of findingsAssociated with changesIssues of reliabilityBrainInterindividual heterogeneityMethodological challengesEventual policy changePsychopathologyFindingsNeuroscienceAdolescentsAdulthoodChildhoodPolicy changesReplicate testsChildrenAdvanced analytical approachesInterventionEarly childhood household instability, adolescent structural neural network architecture, and young adulthood depression: A 21-year longitudinal study
Hardi F, Goetschius L, Tillem S, McLoyd V, Brooks-Gunn J, Boone M, Lopez-Duran N, Mitchell C, Hyde L, Monk C. Early childhood household instability, adolescent structural neural network architecture, and young adulthood depression: A 21-year longitudinal study. Developmental Cognitive Neuroscience 2023, 61: 101253. PMID: 37182338, PMCID: PMC10200816, DOI: 10.1016/j.dcn.2023.101253.Peer-Reviewed Original ResearchConceptsNeural mechanismsNeural mechanisms of riskStructural network organizationIncreased depressive symptomsMechanisms of riskLevels of symptomsMental health concernsStructural network efficiencyWhite matter structuresAdulthood anxietyDepressive symptomsGlobal network efficiencyHousehold instabilityNeural developmentTemporal regionsLongitudinal sampleStructural connectivityFronto-lateralMatter structuresExploratory analysisNetwork efficiencyNetwork organizationDepressionWhite matterSymptoms
2022
Adolescent functional network connectivity prospectively predicts adult anxiety symptoms related to perceived COVID‐19 economic adversity
Hardi F, Goetschius L, McLoyd V, Lopez‐Duran N, Mitchell C, Hyde L, Beltz A, Monk C. Adolescent functional network connectivity prospectively predicts adult anxiety symptoms related to perceived COVID‐19 economic adversity. Journal Of Child Psychology And Psychiatry 2022, 64: 918-929. PMID: 36579796, PMCID: PMC9880614, DOI: 10.1111/jcpp.13749.Peer-Reviewed Original ResearchConceptsFunctional network connectivityDorsal anterior cingulateEconomic adversitySusceptible to adversityUnsupervised community detection algorithmFunctional neural connectivityVentral striatumSubgenual cingulateAnterior cingulateEmotional processingAnxiety symptomsNeural signaturesEmotional networkBrain regionsNeuroimaging dataPopulation-based sampleA individualsStressful eventsAnxietySelf-ReportAdverse experiencesSubgroup membershipNeural connectionsDepressionYoung adults