Erica Hwang
Research
Publications
2024
Association between fine particulate matter and eczema: A cross-sectional study of the All of Us Research Program and the Center for Air, Climate, and Energy Solutions.
Chen G, Hwang E, Leonard C, Cohen J. Association between fine particulate matter and eczema: A cross-sectional study of the All of Us Research Program and the Center for Air, Climate, and Energy Solutions. PLOS ONE 2024, 19: e0310498. PMID: 39536018, PMCID: PMC11560005, DOI: 10.1371/journal.pone.0310498.Peer-Reviewed Original ResearchConceptsPM2.5 concentrationsAmbient air pollutionUs Research ProgramAir pollutionCross-sectional studyAnnual PM2.5 concentrationCohort of American adultsPM2.5 exposureParticulate matterPM2.5Odds of eczemaPrevalence of eczemaAssociated with eczemaRisk of eczemaEnvironmental hazardsAtopic comorbiditiesPollutionSmoking statusTargeted interventionsZip codesAmerican adultsLogistic regressionAmerican cohortDemographic factorsOne-way analysis of varianceSpatial transcriptomics reveals organized and distinct immune activation in cutaneous granulomatous disorders
Daccache J, Park E, Junejo M, Abdelghaffar M, Hwang E, Mohanty C, Singh C, Wang G, Wheeler J, Shields B, Nelson C, Wang Y, Damsky W. Spatial transcriptomics reveals organized and distinct immune activation in cutaneous granulomatous disorders. Journal Of Allergy And Clinical Immunology 2024, 154: 1216-1231. PMID: 39098508, PMCID: PMC11560686, DOI: 10.1016/j.jaci.2024.07.021.Peer-Reviewed Original ResearchCutaneous sarcoidosisNecrobiotic xanthogranulomaGranulomatous disorderGranuloma annulareNecrobiosis lipoidicaImmune activationMacrophage activationCutaneous granulomatous disordersPattern of immune activationType 2 immune activationActivation of Th1Pattern of Th1Alternative macrophage activationAlternative macrophage polarizationAlteration of extracellular matrixPatterns of macrophage activationCases of CSPredominant inflammationExtracellular matrix alterationsTh17 immunityT-helperTh2 polarizationIL-32Histological changesChemokine signalingLB863 Spatial transcriptomics reveals structurally organized and distinct immune polarization in inflammatory cutaneous granulomatous disorders
Daccache J, Park E, Junejo M, Abdelghaffar M, Hwang E, Mohanty C, Singh C, Wang G, Wheeler J, Shields B, Nelson C, Wang Y, Damsky W. LB863 Spatial transcriptomics reveals structurally organized and distinct immune polarization in inflammatory cutaneous granulomatous disorders. Journal Of Investigative Dermatology 2024, 144: s150. DOI: 10.1016/j.jid.2024.06.1243.Peer-Reviewed Original ResearchFacile adipocyte uptake and liver/adipose tissue delivery of conjugated linoleic acid-loaded tocol nanocarriers for a synergistic anti-adipogenesis effect
Hsu C, Liao C, Lin Z, Alalaiwe A, Hwang E, Lin T, Fang J. Facile adipocyte uptake and liver/adipose tissue delivery of conjugated linoleic acid-loaded tocol nanocarriers for a synergistic anti-adipogenesis effect. Journal Of Nanobiotechnology 2024, 22: 50. PMID: 38317220, PMCID: PMC10845550, DOI: 10.1186/s12951-024-02316-8.Peer-Reviewed Original ResearchConceptsAcetyl-CoA carboxylaseFatty acid synthaseAnti-adipogenesis effectConjugated linoleic acidLipogenic enzymes acetyl-CoA carboxylaseEnzyme acetyl-CoA carboxylaseNanostructured lipid carriersIn vitro adipocyte modelsAnti-adipogenic activityAcid synthaseAdipogenesis inhibitionAdipocyte modelInhibit adipogenesisAdipose tissueAdipocytesAdipogenesisAdipocyte hypertrophyIn vivo rat modelLipid-based nanocarriersA-tocopherolReduced body weightObese ratsRat modelTotal cholesterolFat accumulation
2023
Retrospective assessment of immunologic and histologic heterogeneity in granuloma annulare by cytokine staining
Hwang E, Lee T, Okifo K, Murphy M, Damsky W. Retrospective assessment of immunologic and histologic heterogeneity in granuloma annulare by cytokine staining. International Journal Of Dermatology 2023, 63: 655-659. PMID: 38135676, PMCID: PMC11055676, DOI: 10.1111/ijd.16998.Peer-Reviewed Original ResearchNeutrophil-targeted combinatorial nanosystems for suppressing bacteremia-associated hyperinflammation and MRSA infection to improve survival rates
Chang Y, Lin C, Chen C, Hwang E, Alshetaili A, Yu H, Fang J. Neutrophil-targeted combinatorial nanosystems for suppressing bacteremia-associated hyperinflammation and MRSA infection to improve survival rates. Acta Biomaterialia 2023, 174: 331-344. PMID: 38061677, DOI: 10.1016/j.actbio.2023.11.040.Peer-Reviewed Original ResearchConceptsMethicillin-resistant Staphylococcus aureusMethicillin-resistant Staphylococcus aureus infectionIntracellular bacterial countsMouse bacteremia modelBacteremia modelSurvival rateEffective treatmentInhibition of cytokine releaseMedian survival timeDecreased neutrophil activationImproved survival ratesOrgan distributionIncreased survival rateMRSA coloniesAntibody-conjugated nanoparticlesMRSA burdenOrgan dysfunctionCytokine releaseLy6GCytokine/chemokine releaseProlonged circulationPeripheral organsTargeted nanoparticlesFree drugSurvival timeMachine learning analysis of pretreatment skin biopsies predicts nonresponse to dupilumab in patients with eczematous dermatitis
Murphy M, Hwang E, Singh K, Lee T, Cohen J, Damsky W. Machine learning analysis of pretreatment skin biopsies predicts nonresponse to dupilumab in patients with eczematous dermatitis. British Journal Of Dermatology 2023, 190: 132-134. PMID: 37818837, DOI: 10.1093/bjd/ljad389.Peer-Reviewed Original ResearchTopically applied pH-responsive nanogels for alkyl radical-based therapy against psoriasiform hyperplasia
Nirmal G, Liao C, Lin Z, Alshetaili A, Hwang E, Yang S, Fang J. Topically applied pH-responsive nanogels for alkyl radical-based therapy against psoriasiform hyperplasia. Drug Delivery 2023, 30: 2245169. PMID: 37585684, PMCID: PMC10416745, DOI: 10.1080/10717544.2023.2245169.Peer-Reviewed Original ResearchSmall interfering RNA-based nanotherapeutics for treating skin-related diseases
Chang Y, Huang T, Alalaiwe A, Hwang E, Fang J. Small interfering RNA-based nanotherapeutics for treating skin-related diseases. Expert Opinion On Drug Delivery 2023, 20: 757-772. PMID: 37088710, DOI: 10.1080/17425247.2023.2206646.Peer-Reviewed Original ResearchConceptsDifferent nanoparticle typesMechanism of RNAiRNA interferenceSkin delivery systemsLarge-scale productionNanoparticle productsSiRNA deliveryNanoparticle typesSiRNA applicationCutaneous targetingSkin targetingSkin disease managementSkin deliveryPotential applicationsDelivery systemGreat potentialNanocarriersNanotherapeuticsSkin-related diseasesSkin therapySkin penetrationNucleic acidsImproved targetingNanoparticlesTargeting
2022
The role of cytokines/chemokines in an aging skin immune microenvironment
Lin Z, Hsu C, Hwang E, Wang P, Fang J. The role of cytokines/chemokines in an aging skin immune microenvironment. Mechanisms Of Ageing And Development 2022, 210: 111761. PMID: 36496171, DOI: 10.1016/j.mad.2022.111761.Peer-Reviewed Original ResearchConceptsCytokines/chemokinesCutaneous barrier functionTransepidermal water lossLoss of elasticityImmune environmentImmune microenvironmentImmune cellsLifestyle habitsImmunological perspectiveEpidermal thinningImmune systemOverall healthChemokinesBarrier functionSkin agingIndividual exposurePhysiological declineCell-cell crosstalkSkinCytokinesIndividual healthHost cellsHealthCellsExposure