Emily Sutton, PhD
Postdoctoral AssociateAbout
Research
Publications
2026
Signaling to make human ribosomes: Connections between the cytoplasm and the nucleolus
Lawrence I, Sutton E, Bhaskar S, Baserga S. Signaling to make human ribosomes: Connections between the cytoplasm and the nucleolus. Molecular Cell 2026, 86: 469-490. PMID: 41610859, PMCID: PMC12866967, DOI: 10.1016/j.molcel.2026.01.007.Peer-Reviewed Original ResearchConceptsRibosome biogenesisMammalian target of rapamycin complex 1Extracellular signal-regulated kinaseTarget of rapamycin complex 1Casein kinase IIKinase Signaling PathwayRapamycin complex 1Signal-regulated kinaseMammalian targetPhosphorylation eventsRegulatory networksHuman ribosomeCellular processesProtein phosphorylationMitotic machineryRibosomeCell cycleBiogenesisCellular growthSignaling pathwayHuman cellsCytoplasmic organellesNucleolusCytoplasmProteinA high-throughput screen for nucleolar function reveals a role for the signaling protein, SPRR3, in ribosome biogenesis
Sutton E, Bryant C, Gbenoba J, Lawrence I, Baserga S. A high-throughput screen for nucleolar function reveals a role for the signaling protein, SPRR3, in ribosome biogenesis. Journal Of Biological Chemistry 2026, 302: 111132. PMID: 41513095, PMCID: PMC12876706, DOI: 10.1016/j.jbc.2026.111132.Peer-Reviewed Original ResearchConceptsPre-rRNA transcriptionRibosome biogenesisGenome-wide siRNA screenRegulation of ribosome biogenesisMCF10A breast epithelial cellsNucleolar stress responsePre-ribosomal RNAAkt phosphorylationA549 lung carcinoma cellsProline-rich proteinsBreast epithelial cellsPre-rRNASiRNA screenPhosphorylation of AktNucleolar functionSignaling proteinsHigh-throughput screeningSerine 473MCF10A cellsBiogenesisLung carcinoma cellsNucleolar numberRibosomeStress responseAssociated with cancer
2022
Time-Dependent Studies of Oxaliplatin and Other Nucleolar Stress-Inducing Pt(II) Derivatives
Pigg H, Yglesias M, Sutton E, McDevitt C, Shaw M, DeRose V. Time-Dependent Studies of Oxaliplatin and Other Nucleolar Stress-Inducing Pt(II) Derivatives. ACS Chemical Biology 2022, 17: 2262-2271. PMID: 35917257, DOI: 10.1021/acschembio.2c00399.Peer-Reviewed Original ResearchConceptsNucleolar stressStress inductionHigh overall degreeSpecific cellular responsesRibosome biogenesisRRNA transcriptionConformation showCellular responsesCell deathDNA damageKey intermolecular interactionsH drug treatmentMechanistic understandingCellular accumulationSmall moleculesDNA adduct formationInductionBiogenesisTranscriptionStressInhibitionAdduct formationInteractionPotential explanationConformation
2021
Early nucleolar responses differentiate mechanisms of cell death induced by oxaliplatin and cisplatin
Sutton EC, DeRose VJ. Early nucleolar responses differentiate mechanisms of cell death induced by oxaliplatin and cisplatin. Journal Of Biological Chemistry 2021, 296: 100633. PMID: 33819479, PMCID: PMC8131322, DOI: 10.1016/j.jbc.2021.100633.Peer-Reviewed Original Research
2019
Tracking the cellular targets of platinum anticancer drugs: Current tools and emergent methods
Sutton E, McDevitt C, Yglesias M, Cunningham R, DeRose V. Tracking the cellular targets of platinum anticancer drugs: Current tools and emergent methods. Inorganica Chimica Acta 2019, 498: 118984. DOI: 10.1016/j.ica.2019.118984.Peer-Reviewed Original ResearchNucleolar Stress Induction by Oxaliplatin and Derivatives
Sutton EC, McDevitt CE, Prochnau JY, Yglesias MV, Mroz AM, Yang MC, Cunningham RM, Hendon CH, DeRose VJ. Nucleolar Stress Induction by Oxaliplatin and Derivatives. Journal Of The American Chemical Society 2019, 141: 18411-18415. PMID: 31670961, PMCID: PMC7735645, DOI: 10.1021/jacs.9b10319.Peer-Reviewed Original ResearchMonofunctional platinum(II) compounds and nucleolar stress: is phenanthriplatin unique?
McDevitt CE, Yglesias MV, Mroz AM, Sutton EC, Yang MC, Hendon CH, DeRose VJ. Monofunctional platinum(II) compounds and nucleolar stress: is phenanthriplatin unique? JBIC Journal Of Biological Inorganic Chemistry 2019, 24: 899-908. PMID: 31494760, PMCID: PMC7660985, DOI: 10.1007/s00775-019-01707-9.Peer-Reviewed Original Research