Emily Sirotich
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Research
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Featured Publications
Definition of a critical bleed in patients with immune thrombocytopenia: Communication from the ISTH SSC Subcommittee on Platelet Immunology
Sirotich E, Guyatt G, Gabe C, Ye Z, Beck C, Breakey V, Cooper N, Cuker A, Charness J, de Wit K, DiRaimo J, Fein S, Grace R, Hassan Z, Jamula E, Kang M, Manski C, O'Connor C, Pai M, Paynter D, Porter S, Pruitt B, Strachan G, Webert K, Yan J, Kelton J, Bakchoul T, Arnold D. Definition of a critical bleed in patients with immune thrombocytopenia: Communication from the ISTH SSC Subcommittee on Platelet Immunology. Journal Of Thrombosis And Haemostasis 2021, 19: 2082-2088. PMID: 34327824, DOI: 10.1111/jth.15368.Peer-Reviewed Original ResearchConceptsImmune thrombocytopeniaSevere thrombocytopeniaGuideline panelCritical anatomical sitesLow platelet countISTH SSC SubcommitteeBleeding eventsMajor bleedsOngoing bleedPlatelet immunologyCompartment syndromeHemodynamic instabilityRespiratory compromisePhysiologic riskPlatelet countAutoimmune diseasesUrgent treatmentPatient representativesAnatomical sitesThrombocytopeniaUpcoming guidelinesPatientsBleedStandardized definitionsClinical expertsRemoving barriers and disparities in health: lessons from the COVID-19 pandemic
Sirotich E, Hausmann J. Removing barriers and disparities in health: lessons from the COVID-19 pandemic. Nature Reviews Rheumatology 2020, 17: 125-126. PMID: 33028959, PMCID: PMC7540430, DOI: 10.1038/s41584-020-00524-8.Peer-Reviewed Original ResearchPerformance characteristics of platelet autoantibody testing for the diagnosis of immune thrombocytopenia using strict clinical criteria
Gabe C, Sirotich E, Li N, Ivetic N, Nazy I, Smith J, Kelton J, Arnold D. Performance characteristics of platelet autoantibody testing for the diagnosis of immune thrombocytopenia using strict clinical criteria. British Journal Of Haematology 2021, 194: 439-443. PMID: 34109621, DOI: 10.1111/bjh.17566.Peer-Reviewed Original ResearchConceptsPlatelet autoantibody testingImmune thrombocytopeniaAutoantibody testingPlatelet autoantibodiesITP patientsDiagnosis of ITPCertain patient subsetsAnti-glycoprotein IIb/IIIaStrict clinical criteriaHigh pretest probabilityAntigen capture assayIIb/IIIaPatient subsetsClinical criteriaPretest probabilityTreatment responsePatientsHigher optical density valuesOptical density valuesThrombocytopeniaAutoantibodiesCapture assayDiagnosisSpecificityTestingPutting patients at the centre of COVID-19 research.
Sirotich E. Putting patients at the centre of COVID-19 research. Nature 2020 PMID: 32710008, DOI: 10.1038/d41586-020-02226-3.Peer-Reviewed Original Research
2024
Treatment of Critical Bleeds in Patients With Immune Thrombocytopenia: A Systematic Review
Chowdhury S, Sirotich E, Guyatt G, Gill D, Modi D, Venier L, Mahamad S, Chowdhury M, Eisa K, Beck C, Breakey V, de Wit K, Porter S, Webert K, Cuker A, O'Connor C, ‐DiRaimo J, Yan J, Manski C, Kelton J, Kang M, Strachan G, Hassan Z, Pruitt B, Pai M, Grace R, Paynter D, Charness J, Cooper N, Fein S, Agarwal A, Nazaryan H, Siddiqui I, Leong R, Pallapothu S, Wen A, Xu E, Liu B, Shafiee A, Rathod P, Kwon H, Dookie J, Zeraatkar D, Thabane L, Couban R, Arnold D. Treatment of Critical Bleeds in Patients With Immune Thrombocytopenia: A Systematic Review. European Journal Of Haematology 2024 PMID: 39552264, DOI: 10.1111/ejh.14351.Peer-Reviewed Original ResearchImmune thrombocytopeniaCritical bleedingTPO-RAsPlatelet transfusionsCritically bleeding patientsPlatelet count responseSystematic reviewReview of treatmentBleeding patientsIVIGEvidence-based protocolsBleedingBleeding emergenciesCorticosteroidsSystematic review of treatmentsPatientsSplenectomyPatient outcomesIndividualized treatmentThrombocytopeniaPlateletTransfusionEffects of individual treatmentsTreatmentStudy designDermatologist and pharmacist perspectives of a collaborative co-management program
Sirotich E, Katini S, Stroedecke N, Luon S, Cohen J. Dermatologist and pharmacist perspectives of a collaborative co-management program. Archives Of Dermatological Research 2024, 316: 460. PMID: 38967646, DOI: 10.1007/s00403-024-03202-x.Peer-Reviewed Original ResearchRestrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support
Radford M, Estcourt L, Sirotich E, Pitre T, Britto J, Watson M, Brunskill S, Fergusson D, Dorée C, Arnold D. Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support. 2024, 2024: cd011305. PMID: 38780066, PMCID: PMC11112982, DOI: 10.1002/14651858.cd011305.pub3.Peer-Reviewed Original ResearchConceptsRed blood cell transfusion strategyHaematopoietic stem cell transplantationLiberal transfusion strategyClinically significant bleedingRestrictive transfusion strategyNon-randomised studiesTransfusion strategyIntensive chemotherapyRandomised controlled trialsRed blood cellsSignificant bleedingAll-cause mortalityLength of hospital admissionAcute leukemiaHaematological malignanciesRisk of clinically significant bleedingHaematopoietic stem cell supportProspective non-randomised studyRisk ratioControlled trialsQuality of lifeStem cell supportStem cell transplantationMalignant haematological disordersCochrane Central Register of Controlled TrialsRole of Creation of Plain Language Summaries to Disseminate COVID-19 Research Findings to Patients With Rheumatic Diseases
Maheswaranathan M, Akpabio A, Tomasella L, Coler-Reilly A, Richards D, Howard R, Gore-Massy M, Ladone N, Sirotich E. Role of Creation of Plain Language Summaries to Disseminate COVID-19 Research Findings to Patients With Rheumatic Diseases. The Journal Of Rheumatology 2024, 51: jrheum.2023-0998. PMID: 38224986, DOI: 10.3899/jrheum.2023-0998.Peer-Reviewed Original ResearchTreatment of critical bleeding events in patients with immune thrombocytopenia: a protocol for a systematic review and meta-analysis
Sirotich E, Nazaryan H, Chowdhury S, Guyatt G, Agarwal A, Leong R, Wen A, Xu E, Liu B, Pallapothu S, Rathod P, Kwon H, Dookie J, Shafiee A, Charness J, DiRaimo J, Paynter D, Pruitt B, Strachan G, Couban R, Ye Z, Arnold D. Treatment of critical bleeding events in patients with immune thrombocytopenia: a protocol for a systematic review and meta-analysis. Systematic Reviews 2024, 13: 21. PMID: 38184622, PMCID: PMC10770981, DOI: 10.1186/s13643-023-02436-6.Peer-Reviewed Original ResearchConceptsCritical bleedingSystematic reviewEvidence-based treatment protocolsBleeding-related mortalityCochrane Central RegisterEvidence-based recommendationsFull-text screeningBleeding eventsImmune thrombocytopeniaRecommendations AssessmentCentral RegisterControlled TrialsPrimary outcomeSevere thrombocytopeniaPlatelet countEligible studiesPatient outcomesEmergency settingOvid MEDLINEObservational studyTreatment protocolHigh riskMedical emergencyElectronic databasesMethodsLiterature search
2023
Impact of Risk Factors on COVID‐19 Outcomes in Unvaccinated People With Rheumatic Diseases: A Comparative Analysis of Pandemic Epochs Using the COVID‐19 Global Rheumatology Alliance Registry
Yazdany J, Ware A, Wallace Z, Bhana S, Grainger R, Hachulla E, Richez C, Cacoub P, Hausmann J, Liew J, Sirotich E, Jacobsohn L, Strangfeld A, Mateus E, Hyrich K, Gossec L, Carmona L, Lawson‐Tovey S, Kearsley‐Fleet L, Schaefer M, Ribeiro S, Al‐Emadi S, Hasseli R, Müller‐Ladner U, Specker C, Schulze‐Koops H, Bernardes M, Fraga V, Rodrigues A, Sparks J, Ljung L, Di Giuseppe D, Tidblad L, Wise L, Duarte‐García A, Ugarte‐Gil M, Colunga‐Pedraza I, Martínez‐Martínez M, Alpizar‐Rodriguez D, Xavier R, Isnardi C, Pera M, Pons‐Estel G, Izadi Z, Gianfrancesco M, Carrara G, Scirè C, Zanetti A, Machado P. Impact of Risk Factors on COVID‐19 Outcomes in Unvaccinated People With Rheumatic Diseases: A Comparative Analysis of Pandemic Epochs Using the COVID‐19 Global Rheumatology Alliance Registry. Arthritis Care & Research 2023, 76: 274-287. PMID: 37643903, DOI: 10.1002/acr.25220.Peer-Reviewed Original ResearchB-cell depleting therapySevere COVID-19Rheumatic diseasesCOVID-19 outcomesUnvaccinated peopleRisk factorsWorse outcomesCOVID-19Severe COVID-19 outcomesTumor necrosis factor inhibitorsHigh disease activityNecrosis factor inhibitorsConnective tissue diseaseCOVID-19 severityCOVID-19 vaccineThird of individualsLogistic regression modelsCOVID-19 diagnosisOrdinal logistic regression modelsLow HDI regionsMore comorbiditiesUnvaccinated patientsDisease activityUnvaccinated individualsFactor inhibitors