Emily Sharp, PhD, ABPP
Associate Professor of NeurologyCards
About
Research
Publications
Featured Publications
Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [11C]UCB‐J
Mecca AP, O'Dell RS, Sharp ES, Banks ER, Bartlett HH, Zhao W, Lipior S, Diepenbrock NG, Chen M, Naganawa M, Toyonaga T, Nabulsi NB, Vander Wyk B, Arnsten AFT, Huang Y, Carson RE, van Dyck C. Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [11C]UCB‐J. Alzheimer's & Dementia 2022, 18: 2527-2536. PMID: 35174954, PMCID: PMC9381645, DOI: 10.1002/alz.12582.Peer-Reviewed Original ResearchConceptsSynaptic densityEarly Alzheimer's diseaseAlzheimer's diseaseCognitive performanceMajor pathological correlateGray matter volumePositron emission tomography (PET) imagingEmission Tomography ImagingPET imaging studiesIndividual cognitive domainsNeuropathologic studiesSignificant positive associationSynapse lossSynaptic alterationsPathological correlatesNeuropsychological test performanceMatter volumeCognitive impairmentSignificant associationImaging studiesDiseaseTomography imagingGlobal cognitionStrongest predictorPositive association
2024
Self‐reported hearing loss is associated with faster cognitive and functional decline but not diagnostic conversion in the ADNI cohort
Miller A, Sharp E, Wang S, Zhao Y, Mecca A, van Dyck C, O'Dell R, Initiative F. Self‐reported hearing loss is associated with faster cognitive and functional decline but not diagnostic conversion in the ADNI cohort. Alzheimer's & Dementia 2024 PMID: 39324520, DOI: 10.1002/alz.14252.Peer-Reviewed Original ResearchSelf-reported hearing lossFunctional Activities QuestionnaireHearing lossMild cognitive impairmentModifiable risk factorsMild cognitive impairment participantsFunctional declineImpairment diagnosisModified Preclinical Alzheimer Cognitive CompositeRate of functional declineRate of cognitive declinePreclinical Alzheimer Cognitive CompositeRisk factorsCognitive impairmentSignificant longitudinal associationsActivity QuestionnaireLongitudinal associationsAlzheimer's Disease Neuroimaging InitiativeLongitudinal relationshipCognitive compositeCN participantsIncreased riskCognitive declineParticipantsDiagnostic conversionDesign and implementation of community consultation for research conducted under exception from informed consent regulations for the PreVent and the PreVent 2 trials: Changes over time and during the COVID-19 pandemic
Gugel T, Adams K, Baranoski M, Yanez N, Kampp M, Johnson T, Aydin A, Fajardo E, Sharp E, Potnis A, Johnson C, Treggiari M. Design and implementation of community consultation for research conducted under exception from informed consent regulations for the PreVent and the PreVent 2 trials: Changes over time and during the COVID-19 pandemic. Clinical Trials 2024, 21: 671-680. PMID: 38676438, PMCID: PMC11512686, DOI: 10.1177/17407745241243045.Peer-Reviewed Original ResearchPublic disclosure activitiesCommunity consultationInstitutional review boardConsent regulationsIn-personEmergency researchRegulatory measuresCOVID-19 pandemicPublic disclosureSponsor-investigatorsPublic supportPrevention experimentsCommunity leadersIn-person eventsYear of implementationFood and Drug AdministrationHigher education levelCommunity concernsReview boardSelection biasProportion of respondentsMethod of contactClinical researchLocal communitiesCOVID-19
2020
Gene-Environment Covariance as a Mechanism of Declines in Openness in Late Adulthood
Beam C, Sharp E. Gene-Environment Covariance as a Mechanism of Declines in Openness in Late Adulthood. Innovation In Aging 2020, 4: 462-462. PMCID: PMC7742976, DOI: 10.1093/geroni/igaa057.1495.Peer-Reviewed Original Research
2019
Openness Declines in Advance of Death in Late Adulthood
Sharp ES, Beam CR, Reynolds CA, Gatz M. Openness Declines in Advance of Death in Late Adulthood. Psychology And Aging 2019, 34: 124-138. PMID: 30667240, PMCID: PMC6441733, DOI: 10.1037/pag0000328.Peer-Reviewed Original Research
2018
Effects of Normative Adjustments to the Montreal Cognitive Assessment
Pugh EA, Kemp EC, van Dyck CH, Mecca AP, Sharp ES, Initiative F. Effects of Normative Adjustments to the Montreal Cognitive Assessment. American Journal Of Geriatric Psychiatry 2018, 26: 1258-1267. PMID: 30314940, PMCID: PMC6779033, DOI: 10.1016/j.jagp.2018.09.009.Peer-Reviewed Original Research
2017
Personality predicts mortality risk: An integrative data analysis of 15 international longitudinal studies
Graham E, Rutsohn J, Turiano N, Bendayan R, Batterham P, Gerstorf D, Katz M, Reynolds C, Sharp E, Yoneda T, Bastarache E, Elleman L, Zelinski E, Johansson B, Kuh D, Barnes L, Bennett D, Deeg D, Lipton R, Pedersen N, Piccinin A, Spiro A, Muniz-Terrera G, Willis S, Schaie K, Roan C, Herd P, Hofer S, Mroczek D. Personality predicts mortality risk: An integrative data analysis of 15 international longitudinal studies. Journal Of Research In Personality 2017, 70: 174-186. PMID: 29230075, PMCID: PMC5722274, DOI: 10.1016/j.jrp.2017.07.005.Peer-Reviewed Original ResearchPattern of protective effectsLow conscientiousnessHigh neuroticismIntegrative data analysisPersonality traitsOlder baseline ageInternational longitudinal studyExtraversionNeuroticismLongitudinal studyPredictor of mortality riskBaseline ageU.S. studiesPersonsMortality riskAgreeablenessConscientiousnessPredictorsPredictors of mortalityParticipantsTraitsSmokingProtective effectAgeStudyCOGNITIVE TRAJECTORY PATTERNS PREDICT INCIDENT DEMENTIA RISK IN OLDER SWEDISH ADULTS
Munoz E, Gatz M, Pedersen N, Sharp E, Reynolds C. COGNITIVE TRAJECTORY PATTERNS PREDICT INCIDENT DEMENTIA RISK IN OLDER SWEDISH ADULTS. Innovation In Aging 2017, 1: 708-708. PMCID: PMC6248351, DOI: 10.1093/geroni/igx004.2535.Peer-Reviewed Original ResearchSwedish Adoption/Twin StudyExecutive function tasksCognitive performance measuresDementia riskAverage performance levelEpisodic memoryFunction tasksVerbal domainSpatial abilityCognitive trajectoriesCognitive dataLevel of performanceAdditional tasksSwedish adultsHARMONY studyTwin studiesMemoryAge 65Dementia onsetPerformance levelTaskTotal sampleAdultsIncident dementiaLinear decline
2011
Relationship Between Education and Dementia
Sharp ES, Gatz M. Relationship Between Education and Dementia. Alzheimer Disease & Associated Disorders 2011, 25: 289-304. PMID: 21750453, PMCID: PMC3193875, DOI: 10.1097/wad.0b013e318211c83c.Peer-Reviewed Original Research
2010
Cognitive Engagement and Cognitive Aging: Is Openness Protective?
Sharp ES, Reynolds CA, Pedersen NL, Gatz M. Cognitive Engagement and Cognitive Aging: Is Openness Protective? Psychology And Aging 2010, 25: 60-73. PMID: 20230128, PMCID: PMC2853722, DOI: 10.1037/a0018748.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overAlzheimer DiseaseCardiovascular DiseasesCognition DisordersDiseases in TwinsEducational StatusExploratory BehaviorFemaleHumansInterpersonal RelationsLeisure ActivitiesLongitudinal StudiesMaleMiddle AgedModels, PsychologicalMotivationSocial BehaviorStatistics as TopicSurveys and QuestionnairesTemperamentConceptsCognitive performanceSwedish Adoption/Twin StudyHigher cognitive test scoresLatent growth curve modelsCognitive test scoresGrowth curve modelsVerbal abilityCognitive agingCognitive domainsCognitive engagementCognitive testsSpatial abilityProcessing speedCognitive declineTest scoresLongitudinal trajectoriesHigh opennessTwin studiesCurve modelLongitudinal changesGlobal scoreOpennessDaily livingIndividualsMemory
Clinical Trials
Current Trials
Cognitive Training in Parkinson's Disease
HIC ID2000033352RoleSub InvestigatorPrimary Completion Date12/31/2027Recruiting ParticipantsGenderBothAge40+ years
Clinical Care
Overview
Emily Sharp, PhD, is a neuropsychologist at Yale Medicine with a specialty focus in memory disorders and Parkinson’s disease.
Dr. Sharp uses specialized neuropsychological measures to assess patients’ cognitive and emotional functioning, which provides neurologists and primary care physicians with important data for diagnosis and treatment planning.
“Neuropsychological testing allows us to see how a patient is doing within each domain of thinking, like memory, language, and attention. And those domains of thinking tend to correlate with different disorders. That can help the neurologist or referring provider better understand what’s going on,” she says.
Dr. Sharp spends several hours with patients, and interviews family members and caregivers, to form a complete picture of a patient’s current abilities. This information is then compiled into a detailed report with recommendations for the referring physician.
Dr. Sharp completed her PhD at the University of Southern California before finishing a two-year neuropsychology fellowship in Boston. Soon after, she joined Yale Medicine.
In addition to seeing patients, Dr. Sharp conducts research on the relationship between cognitive engagement and cognitive decline. She has a specific interest in interventions designed to identify, delay, and reduce the burden of cognitive impairment. She is a member of the clinical core faculty for the Yale Alzheimer’s Disease Research Center.