Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsDenny Sakkas, PhD
About
Research
Publications
2026
Microfluidic automation improves oocyte recovery from follicular fluid of patients undergoing in vitro fertilization
Mutlu B, Civale S, Diettrich J, Gupta N, Barber T, Sayare M, Penzias A, Alper M, Toth T, Kapur R, Toner M, Sakkas D, Ozkumur E. Microfluidic automation improves oocyte recovery from follicular fluid of patients undergoing in vitro fertilization. Nature Medicine 2026, 32: 906-914. PMID: 41680481, PMCID: PMC13004694, DOI: 10.1038/s41591-026-04207-x.Peer-Reviewed Original ResearchConceptsIn vitro fertilizationFollicular fluidOocyte recoveryIn vitro fertilization success rateFollicular fluid of patientsHigh-quality blastocystsPatient treatmentIn vitro fertilization centerFluid of patientsLive birthsTreatment optionsClinical studiesEmbryo poolsMature oocytesGlobal health challengeFF samplesOocytesClinical practicePatientsSuccess rateTreatmentHealth challengesBlastocystInfertilityReply: immature oocyte proportion may or may not compromise ICSI outcomes, but methods do: a critical appraisal
Sripada V, Sakkas D, Vaughan D, Morse B, Fouks Y. Reply: immature oocyte proportion may or may not compromise ICSI outcomes, but methods do: a critical appraisal. Human Reproduction 2026, deag013. PMID: 41653405, DOI: 10.1093/humrep/deag013.Commentaries, Editorials and LettersThe impact of endometrial fluid on single euploid frozen embryo transfers, to cancel or not?
Patel K, Sakkas D, Morse B, Duvall D, Penzias A, Vaughan D. The impact of endometrial fluid on single euploid frozen embryo transfers, to cancel or not? Human Reproduction 2026, 41: 353-360. PMID: 41639890, DOI: 10.1093/humrep/deag010.Peer-Reviewed Original ResearchConceptsEuploid frozen embryo transferFrozen embryo transferLive birth rateFrozen embryo transfer cyclesEuploid FET cyclesEndometrial fluidCycle cancellationIncidence of EFEmbryo transferEuploid embryosEF groupFET cyclesPresence of EFLow incidenceLower live birth ratesPre-implantation genetic testingInclusion criteriaStudy funding/competing interest(sRetrospective cohort studyLogistic regression analysisSecondary analysisStatistically significant differenceTrophectoderm biopsyEndometrial pathologyCases of EF40th anniversary of Human Reproduction: reflecting on four decades of scientific excellence
Barratt C, Kirkegaard K, Sakkas D, Wise L, Williams A. 40th anniversary of Human Reproduction: reflecting on four decades of scientific excellence. Human Reproduction 2026, 41: 137-137. PMID: 41630363, DOI: 10.1093/humrep/deaf241.Commentaries, Editorials and LettersFertility preservation in patients with medical indications: a committee opinion
Medicine P, Gracia C, Amato P, Anderson J, Flyckt R, Hansen K, Hill M, Jain T, Jindal S, Kalra S, Pier B, Sakkas D, Steiner A, Tanrikut C, Trolice M, Senapati S, Smith R, Plowden T, Yauger B, Brannigan R, Ginsburg E, Robins J, Shannon C, Goldstein J, Brooks M. Fertility preservation in patients with medical indications: a committee opinion. Fertility And Sterility 2026, 125: 247-259. PMID: 41494900, DOI: 10.1016/j.fertnstert.2025.12.001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSperm Chromatin Structure Analysis and Clinical Correlations
Vaughan D, Sakkas D. Sperm Chromatin Structure Analysis and Clinical Correlations. 2026, 139-144. DOI: 10.1016/b978-0-443-21477-6.00048-1.BooksThe Preparation of Sperm
Sakkas D. The Preparation of Sperm. 2026, 196-200. DOI: 10.1016/b978-0-443-21477-6.00268-6.Books
2025
The reproductive endocrinology and infertility subspecialist: definition, training, and scope of practice in the United States
Medicine P, Gracia C, Amato P, Anderson J, Flyckt R, Hansen K, Hill M, Jain T, Jindal S, Kalra S, Pier B, Sakkas D, Steiner A, Tanrikut C, Yauger B, Brannigan R, Ginsburg E, Robins J, Shannon C, Brooks M. The reproductive endocrinology and infertility subspecialist: definition, training, and scope of practice in the United States. Fertility And Sterility 2025, 124: 1201-1209. DOI: 10.1016/j.fertnstert.2025.09.028.Peer-Reviewed Original ResearchReproductive endocrinologyMinimally invasive surgical approachComplex reproductive disorderMedical literatureInvasive surgical approachMolecular causesAssisted Reproductive TechnologyFemale reproductive tractReproductive disordersMinimal tissue traumaReproductive surgeryFemale reproductive systemSurgical approachEndocrine disordersTissue traumaInfertilityReproductive medicineHormone actionReproductive tractReproductive technologyIndividualization of careEndocrinologySubspecialistsLevels of careReproductive systemCapturing aberrant cell behaviors producing defects in human embryos via live imaging
Akizawa H, Domingo-Muelas A, Pardo-Figuerez M, Hernandez B, Ardestani G, Skory R, Venturas M, Tetlak P, Bissiere S, Sakkas D, Simon C, Plachta N. Capturing aberrant cell behaviors producing defects in human embryos via live imaging. Science Advances 2025, 11: eady6402. PMID: 41259532, PMCID: PMC12629204, DOI: 10.1126/sciadv.ady6402.Peer-Reviewed Original ResearchConceptsAberrant cell behaviorHuman embryosHuman preimplantation embryosHuman embryos in vitroEmbryos in vitroCell behaviorAbnormal chromosome organizationChromosome organizationPreimplantation embryosMitotic progressionDaughter cellsCondensed chromosomesMultipolar spindlesLagging chromosomesLive embryo imagingMitotic errorsEnucleated cellsMorphological defectsReproductive medicineDevelopmental failureLive imagingCytokinesisChromosomeComputational analysisEmbryosMitochondrial metabolism influences meiotic maturation in human oocytes of young and advanced maternal age women
Pietroforte S, Martins M, Barragan M, IbaƱez E, Vassena R, Popovic M, Sanchez T, Sakkas D, Zambelli F. Mitochondrial metabolism influences meiotic maturation in human oocytes of young and advanced maternal age women. Human Reproduction 2025, 40: 2260-2271. PMID: 41206610, DOI: 10.1093/humrep/deaf207.Peer-Reviewed Original ResearchConceptsAdvanced maternal ageAdvanced maternal age womenGV oocytesGerminal vesicleMII stageHuman oocytesMeiotic progressionAdvanced maternal age patientsMeiotic progression of oocytesFluorescence mean intensityHuman GV oocytesIn vitro maturationProgression of oocytesMitochondrial activityMitochondrial metabolismGV stageChi-square testGV breakdownImpaired mitochondrial metabolismHigher RatesMaternal ageMeiotic maturationComprehensive metabolismChromosome segregation errorsMetabolic dysfunction