Deguang Song
Associate Research ScientistCards
Contact Info
Immunobiology
10 Amistad RM102
New Haven, CT 06509
United States
About
Copy Link
Titles
Associate Research Scientist
Research
Copy Link
Research at a Glance
Yale Co-Authors
Frequent collaborators of Deguang Song's published research.
Publications Timeline
A big-picture view of Deguang Song's research output by year.
Noah Wolcott Palm, PhD
Jason Crawford, PhD
Anjelica Martin Rajaniemi, BS, RLATG
Mytien Nguyen
Jaime González-Hernández
Andrew Goodman, PhD
13Publications
752Citations
Publications
2026
Commensal-derived acetylcholine enhances mucosal immune education
Song D, Duncan-Lowey B, Khetrapal V, Hamchand R, Deng T, Brown H, Wu A, Martin A, Bauer K, Zhao Y, Nguyen M, Sonnert N, Leopold S, Wu Q, Crawford J, Palm N. Commensal-derived acetylcholine enhances mucosal immune education. Nature 2026, 655: 1027-1036. PMID: 42236946, PMCID: PMC13391359, DOI: 10.1038/s41586-026-10592-7.Peer-Reviewed Original ResearchCitationsAltmetric
2025
Discovery of a Widespread Polyamine–Low-Molecular-Weight Thiol Hybrid Pathway in Clostridioides difficile
Hunt R, Oh J, Jain A, Kuo T, Berardi D, Jian W, Song D, Wu Q, Goodman A, Palm N, Zimmermann M, Johnson C, Crawford J. Discovery of a Widespread Polyamine–Low-Molecular-Weight Thiol Hybrid Pathway in Clostridioides difficile. ACS Infectious Diseases 2025, 11: 2246-2264. PMID: 40671632, PMCID: PMC12403189, DOI: 10.1021/acsinfecdis.5c00286.Peer-Reviewed Original ResearchCitationsAltmetricTryptamine Metabolism and Functionalization in Gut Commensal Bacteria Expand Human Tryptamine Signaling Responses
Park H, Song D, Nguyen M, Palm N, Crawford J. Tryptamine Metabolism and Functionalization in Gut Commensal Bacteria Expand Human Tryptamine Signaling Responses. ACS Chemical Biology 2025, 20: 1775-1782. PMID: 40577169, PMCID: PMC12372651, DOI: 10.1021/acschembio.5c00313.Peer-Reviewed Original ResearchCitationsActivity of GPCR-targeted drugs influenced by human gut microbiota metabolism
Wu Q, Song D, Zhao Y, Verdegaal A, Turocy T, Duncan-Lowey B, Goodman A, Palm N, Crawford J. Activity of GPCR-targeted drugs influenced by human gut microbiota metabolism. Nature Chemistry 2025, 17: 808-821. PMID: 40181149, PMCID: PMC12412589, DOI: 10.1038/s41557-025-01789-w.Peer-Reviewed Original ResearchCitationsAltmetric
2024
Mucosal sugars delineate pyrazine vs pyrazinone autoinducer signaling in Klebsiella oxytoca
Hamchand R, Wang K, Song D, Palm N, Crawford J. Mucosal sugars delineate pyrazine vs pyrazinone autoinducer signaling in Klebsiella oxytoca. Nature Communications 2024, 15: 8902. PMID: 39406708, PMCID: PMC11480411, DOI: 10.1038/s41467-024-53185-6.Peer-Reviewed Original ResearchCitationsAltmetricHuman AKR1C3 binds agonists of GPR84 and participates in an expanded polyamine pathway
Dudkina N, Park H, Song D, Jain A, Khan S, Flavell R, Johnson C, Palm N, Crawford J. Human AKR1C3 binds agonists of GPR84 and participates in an expanded polyamine pathway. Cell Chemical Biology 2024, 32: 126-144.e18. PMID: 39163853, PMCID: PMC11748234, DOI: 10.1016/j.chembiol.2024.07.011.Peer-Reviewed Original ResearchCitationsThe Xenorhabdus nematophila LrhA transcriptional regulator modulates production of γ-keto-N-acyl amides with inhibitory activity against mutualistic host nematode egg hatching
Lam Y, Hamchand R, Mucci N, Kauffman S, Dudkina N, Reagle E, Casanova-Torres Á, DeCuyper J, Chen H, Song D, Thomas M, Palm N, Goodrich-Blair H, Crawford J. The Xenorhabdus nematophila LrhA transcriptional regulator modulates production of γ-keto-N-acyl amides with inhibitory activity against mutualistic host nematode egg hatching. Applied And Environmental Microbiology 2024, 90: e00528-24. PMID: 38916293, PMCID: PMC11267870, DOI: 10.1128/aem.00528-24.Peer-Reviewed Original ResearchCitationsA host–microbiota interactome reveals extensive transkingdom connectivity
Sonnert N, Rosen C, Ghazi A, Franzosa E, Duncan-Lowey B, González-Hernández J, Huck J, Yang Y, Dai Y, Rice T, Nguyen M, Song D, Cao Y, Martin A, Bielecka A, Fischer S, Guan C, Oh J, Huttenhower C, Ring A, Palm N. A host–microbiota interactome reveals extensive transkingdom connectivity. Nature 2024, 628: 171-179. PMID: 38509360, DOI: 10.1038/s41586-024-07162-0.Peer-Reviewed Original ResearchCitationsAltmetric
2023
Mitochondrial dysfunction promotes microbial composition that negatively impacts on ulcerative colitis development and progression
Peña-Cearra A, Song D, Castelo J, Palacios A, Lavín J, Azkargorta M, Elortza F, Fuertes M, Pascual-Itoiz M, Barriales D, Martín-Ruiz I, Fullaondo A, Aransay A, Rodríguez H, Palm N, Anguita J, Abecia L. Mitochondrial dysfunction promotes microbial composition that negatively impacts on ulcerative colitis development and progression. Npj Biofilms And Microbiomes 2023, 9: 74. PMID: 37805634, PMCID: PMC10560208, DOI: 10.1038/s41522-023-00443-y.Peer-Reviewed Original ResearchCitationsAltmetricHighly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions
Chen H, Rosen C, González-Hernández J, Song D, Potempa J, Ring A, Palm N. Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions. Cell 2023, 186: 3095-3110.e19. PMID: 37321219, PMCID: PMC10330796, DOI: 10.1016/j.cell.2023.05.024.Peer-Reviewed Original ResearchCitationsAltmetric
Get In Touch
Copy Link
Contacts
Mailing Address
Immunobiology
10 Amistad RM102
New Haven, CT 06509
United States