David Frankfurter, MD
he/him/his
Professor of Obstetrics, Gynecology and Reproductive SciencesCards
About
Research
Publications
2021
The road to validating preimplantation genetic testing for aneuploidy; are we there yet?
Humm K, Frankfurter D. The road to validating preimplantation genetic testing for aneuploidy; are we there yet? Fertility And Sterility 2021, 115: 585-586. PMID: 33558020, DOI: 10.1016/j.fertnstert.2020.12.029.Commentaries, Editorials and LettersWell-being in trainee and faculty physicians
Frishman G, Raker C, Frankfurter D. Well-being in trainee and faculty physicians. Medical Education Online 2021, 26: 1950107. PMID: 34252014, PMCID: PMC8276666, DOI: 10.1080/10872981.2021.1950107.Peer-Reviewed Original ResearchConceptsObstetrics and GynecologySubspecialty fellowsCross-sectional studyOB/GYN residentsGynecology traineesProgression of trainingDuty hoursPost-graduate traineesOB/GYNU.S. traineesNo differenceGynecologyObstetricsCore facultySubspecialty facultyFaculty physiciansPhysician traineesAssessed differencesSubspecialtyImpacted traineesPhysiciansPhysician well-beingHoursProgressionIntervention
2020
Association of Urinary THC Concentrations and Sperm Abnormalities in US Urban Men
McLeland-Wieser H, Young H, Neumann L, Crites J, Moody D, Irwig M, Frankfurter D, Perry M. Association of Urinary THC Concentrations and Sperm Abnormalities in US Urban Men. ISEE Conference Abstracts 2020, 2020 DOI: 10.1289/isee.2020.virtual.p-1117.Peer-Reviewed Original ResearchThe Association Between Race, Obesity, and Sperm Quality Among Men Attending a University Physician Practice in Washington, DC
McCray N, Young H, Irwig M, Frankfurter D, Schwartz A, Witmyer J, Hynes M, Jayanthi V, Marcus M, Patel M, Perry M. The Association Between Race, Obesity, and Sperm Quality Among Men Attending a University Physician Practice in Washington, DC. American Journal Of Men's Health 2020, 14: 1557988320925985. PMID: 32602769, PMCID: PMC7328221, DOI: 10.1177/1557988320925985.Peer-Reviewed Original ResearchConceptsBody mass indexSperm healthPhysician practicesAssociated with low sperm motilitySperm countWorld Health OrganizationLow sperm motilitySample of U.S. menMen of colorLow sperm countNon-Hispanic menStudy sample sizeSperm motilitySperm concentrationSperm qualitySemen samplesSperm parametersSemen qualityObesity ratesSpermEpidemiological literatureU.S. menHispanic menMass indexAndrological health
2019
Clinical approach to recurrent implantation failure: evidence-based evaluation of the endometrium
Kliman HJ, Frankfurter D. Clinical approach to recurrent implantation failure: evidence-based evaluation of the endometrium. Fertility And Sterility 2019, 111: 618-628. PMID: 30929719, DOI: 10.1016/j.fertnstert.2019.02.011.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsRecurrent implantation failureImplantation failureHigh-quality embryosEvidence-based evaluationInflammatory markersRetained productsInflammatory lesionsHistologic evaluationQuality embryosClinical approachGrowth disordersActionable findingsEndometriumFunctional testsPatientsMolecular eraComplete assessmentTissueCycling tissueEndometrialFailureBest optionLesionsEvaluation
2018
Are too many eggs truly too many?
Comstock I, Frankfurter D. Are too many eggs truly too many? Fertility And Sterility 2018, 110: 632-633. PMID: 30196952, DOI: 10.1016/j.fertnstert.2018.05.030.Commentaries, Editorials and Letters
2015
Preimplantation Genetic Screening
Lalwani S, Witmyer J, Gaba N, Frankfurter D. Preimplantation Genetic Screening. Topics In Obstetrics & Gynecology 2015, 35: 1-5. DOI: 10.1097/01.pgo.0000471712.79930.33.Peer-Reviewed Original ResearchTargeted single molecule sequencing methodology for ovarian hyperstimulation syndrome
Orkunoglu-Suer F, Harralson A, Frankfurter D, Gindoff P, O’Brien T. Targeted single molecule sequencing methodology for ovarian hyperstimulation syndrome. BMC Genomics 2015, 16: 264. PMID: 25888426, PMCID: PMC4397691, DOI: 10.1186/s12864-015-1451-2.Peer-Reviewed Original ResearchConceptsSingle molecule sequencingSequence assemblyMolecule sequencingDNA sequencesFunctional analysis of variantsReal-time DNA sequencingGenome Analysis ToolkitTargeted capture enrichmentBase-calling accuracyGC-rich regionEmulsion PCRHuman DNA samplesConventional Sanger sequencingNext generation sequencingMultiplex polymerase chain reactionDepth of coveragePolymerase chain reactionAnalysis of variantsLong readsRead lengthSequencing methodologiesFunctional variantsGeneration sequencingSanger sequencingYield ampliconsGetting Pregnant with PCOS
Frankfurter D. Getting Pregnant with PCOS. 2015, 317-326. DOI: 10.1007/978-1-4939-2059-4_38.Peer-Reviewed Original ResearchOral contraceptive pillsOCP discontinuationAbnormal Pap smearsIncreased hair growthTransvaginal ultrasoundPeripheral cystsDiffuse enlargementPap smearContraceptive pillsEndometrial liningSkin tagsMenstrual cycleLeft axillaFasting GlucoseDaily multivitaminFasting insulinPhysical examinationBlood pressurePosterior thighMedical problemsHair growthSanitary napkinsDaysGynecologistsTSH
2014
Kinase insert domain receptor/vascular endothelial growth factor receptor 2 (KDR) genetic variation is associated with ovarian hyperstimulation syndrome
O’Brien T, Harralson A, Tran T, Gindoff I, Orkunoglu-Suer F, Frankfurter D, Gindoff P. Kinase insert domain receptor/vascular endothelial growth factor receptor 2 (KDR) genetic variation is associated with ovarian hyperstimulation syndrome. Reproductive Biology And Endocrinology 2014, 12: 36. PMID: 24886133, PMCID: PMC4024119, DOI: 10.1186/1477-7827-12-36.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersCase-Control StudiesChorionic GonadotropinDistrict of ColumbiaDrug ResistanceEstradiolFemaleFertility Agents, FemaleFollicle Stimulating HormoneGenetic Association StudiesGenetic Predisposition to DiseaseHospitals, UniversityHumansLinkage DisequilibriumOvarian Hyperstimulation SyndromeOvaryOvulation InductionPolymorphism, Single NucleotideUltrasonographyVascular Endothelial Growth Factor Receptor-2ConceptsOvarian hyperstimulation syndromeControlled ovarian hyperstimulationOvarian hyperstimulation syndrome developmentEndothelial growth factor receptor 2Hyperstimulation syndromeOvarian response to COHResponse to COHOvarian hyperstimulation syndrome riskPrevention of ovarian hyperstimulation syndromeDevelopment of ovarian hyperstimulation syndromeSingle nucleotide polymorphismsPoor ovarian response to COHAssociated with ovarian hyperstimulation syndromeC-T-GReceptor 2Controlled ovarian stimulationOverdominant modelGenetic variationCase-control studyOvarian stimulationClinical outcome variablesPatient blood samplesOvarian hyperstimulationControl patientsPharmacological prevention
Clinical Care
Overview
David Frankfurter, MD, is a specialist in obstetrics, gynecology, and reproductive endocrinology and infertility (REI). He focuses on helping individuals address challenges related to reproduction and fertility, offering treatments such as hormone therapy and assisted reproductive technologies. He also supports patients to achieve family-planning goals.
As a professor of obstetrics, gynecology, and reproductive sciences at Yale School of Medicine, Dr. Frankfurter conducts research on hormonal influences on fertility and innovative reproductive techniques.
Dr. Frankfurter received his medical degree from Yale School of Medicine and completed his residency in obstetrics and gynecology at Yale New Haven Hospital, followed by a fellowship in reproductive endocrinology and infertility at Beth Israel Deaconess/Harvard University. After completing his training, he joined the Division of Reproductive Endocrinology at Brown University, where he became the director of the donor egg program. In 2003, he transitioned to George Washington University as the medical director of in vitro fertilization (IVF) and division director of REI. He returned to Yale in 2023.
Clinical Specialties
Reproductive Endocrinology & Infertility; Obstetrics, Gynecology & Reproductive Sciences
Fact Sheets
Polycystic Ovary Syndrome (PCOS)
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Learn More on Yale MedicineOvulation Induction and Intrauterine Insemination
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Board Certifications
Reproductive Endocrinology & Infertility
- Certification Organization
- AB of Obstetrics & Gynecology
- Original Certification Date
- 2002
Obstetrics & Gynecology
- Certification Organization
- AB of Obstetrics & Gynecology
- Original Certification Date
- 2000
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