Chiang-Shan Ray Li, MD, PhD
Professor of Psychiatry and of NeuroscienceCards
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Contact Info
Psychiatry
CMHC S112, 34 Park Street
New Haven, CT 06519
United States
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Titles
Professor of Psychiatry and of Neuroscience
Biography
I am a Professor of Psychiatry and of Neuroscience at Yale University School of Medicine. I graduated from National Taiwan University College of Medicine and California Institute of Technology and has been a faculty member at Yale since 2003. My earlier work employed non-human primate models to understand the neural bases of cognition. Current research in my laboratory continues to focus on systems neuroscience. By combining psychophysics, computational modeling and brain imaging we explore the circuit mechanisms of a multitude of cognitive constructs, including self control, affect regulation, and reward-related processes. The primary goals are to understand systems neural bases of these cognitive processes and how these neural processes contribute to the etiology of psychiatric and neurological illnesses, with a specific emphasis on addiction.
Appointments
Psychiatry
ProfessorPrimaryNeuroscience
ProfessorSecondary
Other Departments & Organizations
Education & Training
- Resident
- Chang Gung Memorial Hospital (2001)
- Postdoctoral Associate
- Massachusetts Institute of Technology (1998)
- PhD
- California Institute of Technology, Computation and Neural Systems (1996)
- MD
- National Taiwan University, Medicine (1989)
Research
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Overview
Medical Research Interests
ORCID
0000-0002-9393-1212
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Xingguang Luo, MD
Shefali Chaudhary
Jaime Ide, PhD
Sheng Zhang, PhD
Thang Le, PhD
Herta Chao, MD, PhD
Mental Disorders
Central Nervous System
Drug Users
Nervous System Diseases
Publications
2026
GABAergic bases of connectivity alterations in the ventral tegmental area of young drinkers: An analysis using the combined technologies of JuSpace toolbox and resting-state functional magnetic resonance imaging
Wang S, Hao D, Su Y, Wang X, Yan Y, Chen Y, Li G, Li C. GABAergic bases of connectivity alterations in the ventral tegmental area of young drinkers: An analysis using the combined technologies of JuSpace toolbox and resting-state functional magnetic resonance imaging. Advanced Technology in Neuroscience 2026 DOI: 10.4103/atn.atn-d-25-00031.Peer-Reviewed Original ResearchConceptsVentral tegmental areaResting-state functional connectivityAlcohol use severityVTA connectivityHuman Connectome ProjectMesocortical circuitJuSpace toolboxAssociated with alcohol use severityWhole-brain regression analysesMeasures of alcohol use severityRight inferior frontal gyrusResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingAssociated with alcohol misuseInferior frontal gyrusYoung adultsReward predictionReward circuitSalience processingTegmental areaFrontal gyrusPars opercularisMotivated behaviorNeurochemical mechanismsConnectivity alterationsEarly Clinical Symptom Patterns Predict the Subsequent Treatment Response of Patients with Acute Schizophrenia
Liu Z, Chen W, Wang X, Huang J, Gou M, Han H, Wang J, Wang D, Chen S, Xie T, Tian L, Luo X, Li C, Li Y, Tan Y. Early Clinical Symptom Patterns Predict the Subsequent Treatment Response of Patients with Acute Schizophrenia. Schizophrenia Bulletin 2026, 52: sbag009. PMID: 41863369, PMCID: PMC13005118, DOI: 10.1093/schbul/sbag009.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsPositive and Negative Syndrome ScalePoor treatment respondersClinical symptom patternsSymptom patternsAcute schizophreniaSymptom changeSymptom trajectoriesTreatment respondersPositive and Negative Syndrome Scale changeTreatment responseTreatment outcomesEarly treatment responsePredictors of treatment outcomeEarly symptom changeNegative Syndrome ScaleClinical symptom severityClinical symptom profilesAntipsychotic treatmentLong-term treatment outcomesSyndrome ScalePrediction of treatment responseSymptom severitySymptom profilesWeek 2SchizophreniaHappy and threatening faces differentially influence facilitation and interference over time
Hu K, Hu Y, Liu F, Fan Q, Xu H, Li Q, He S, Li C. Happy and threatening faces differentially influence facilitation and interference over time. Psychological Research 2026, 90: 36. PMID: 41697379, DOI: 10.1007/s00426-026-02237-1.Peer-Reviewed Original ResearchConceptsStages of task performanceMean-level changeFindings challenge modelsInfluence of emotionsHappy facesFlanker taskThreat facesHappy expressionsThreat expressionsEmotional modulationAttentional benefitsFacilitation effectEmotional signalsNeutral baselineTask performanceEarly facilitationEmotional conditionsFacial expressionsFlankerEmotionsFacilitationFaceHabituationHappinessAttentionAlcohol misuse and negative emotion processing in neurotypical drinkers: Sex differences in behavioral and neural markers
Chaudhary S, Chen Y, Wong H, Chao H, Li C. Alcohol misuse and negative emotion processing in neurotypical drinkers: Sex differences in behavioral and neural markers. Psychiatry Research Neuroimaging 2026, 358: 112174. PMID: 41691915, PMCID: PMC12990894, DOI: 10.1016/j.pscychresns.2026.112174.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsNegative emotion processingMiddle frontal gyrusEmotional processingNegative emotionsSex differencesAlcohol misuseProblem drinkingMiddle frontal gyrus activationAssociated with individual differencesBilateral middle frontal gyrusHigher-level cognitive processesPrefrontal cortical activityWhole-brain regressionAlcohol Use Disorders Identification TestAUDIT scoreDisorders Identification TestImpact of negative emotionsFrontal gyrusCommunity sampleIndividual differencesCognitive processesImpact of alcohol misuseNeural markersAlcohol useIdentification TestFunctional inputs to the subgenual cingulate cortex differentiate levels of depressive symptom severity in neurotypical young adults: granger causality and clustering analyses
Li H, Chen Y, Chaudhary S, Ide J, Li C. Functional inputs to the subgenual cingulate cortex differentiate levels of depressive symptom severity in neurotypical young adults: granger causality and clustering analyses. The International Journal Of Neuropsychopharmacology 2026, 29: pyag005. PMID: 41665262, PMCID: PMC12962302, DOI: 10.1093/ijnp/pyag005.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsDepressive symptom severityLevels of depressive symptom severityNeurotypical young adultsSymptom severityGranger causality analysisCingulate cortexNeurotypical populationSubgenual anterior cingulate cortexSubgenual cingulate cortexAnterior cingulate cortexAdult Self-ReportYoung adultsScores of depressionHuman Connectome ProjectOrbitofrontal cortexDepressive disorderAnterior insulaComorbid symptomsDepressive traitsFronto-parietalExternalizing problemsSgACCTemporal cortexBrain regionsFunctional connectivityHippocampal subfield differences in people with and without recreational ketamine use: Insights from multi‐modal neuroimaging
Liu Y, Hung C, Potenza M, Chou K, Lee P, Huang C, Li C, Lee T, Lin C. Hippocampal subfield differences in people with and without recreational ketamine use: Insights from multi‐modal neuroimaging. Addiction 2026 PMID: 41612591, DOI: 10.1111/add.70331.Peer-Reviewed Original ResearchConceptsFunctional connectivityRecreational ketamine usePsychiatric symptomsWorking-memoryKetamine useHippocampal subregionsGroup differencesAssociated with greater psychological distressSelf-reported impulsivityHippocampal subregion volumesWorking-memory loadLeft hippocampal volumeSeed-based analysisHippocampal subfield volumesGreater psychological distressN-methyl-D-aspartateChronic ketamine useMulti-modal neuroimagingReward/punishment sensitivityN-methyl-D-aspartate-N-backNMDA-receptor distributionSubregion volumesCognitive concernsMemory impairment
2025
Proteome-Based Plasma Biomarkers for Cognitive Dysfunction in an Androgen Deprivation Model
Singh V, Verma S, Shankar E, Swain D, Willard B, Chao H, Li C, Lee Z, MacLennan G, Ponsky L, Gupta S. Proteome-Based Plasma Biomarkers for Cognitive Dysfunction in an Androgen Deprivation Model. Molecular Neurobiology 2025, 63: 201. PMID: 41315084, DOI: 10.1007/s12035-025-05548-3.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsAndrogen deprivation therapyCognitive dysfunctionControl miceOral gavage 5 daysProstate cancer patientsAttention deficitGavage 5 daysBrain regionsCognitive functionEvaluation of biomarkersNeurotypical agingCognitive declineCognitive impactPositron emission tomographyDeprivation therapyEnzalutamide treatmentNonsteroidal antiandrogenProstate cancerNano-liquid chromatography tandem mass spectrometryNeuronal densityBehavioral changesPrimary treatmentBALB/c miceCancer patientsMouse modelThe effects of polygenic risks for alcohol misuse on negative emotion processing in young adult binge drinkers
Chen Y, Luo X, Li H, Li G, Ide J, Li C. The effects of polygenic risks for alcohol misuse on negative emotion processing in young adult binge drinkers. Translational Psychiatry 2025, 15: 495. PMID: 41271663, PMCID: PMC12638819, DOI: 10.1038/s41398-025-03719-3.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsNegative emotion processingPolygenic risk scoresEmotional processingBinge drinkersAlcohol misuseNon-bingersNeurobiological processesSymptom severityGenetic riskNegative emotionsProcessing of negative emotionsSeverity of somatic complaintsResponse to negative emotionsEffect of polygenic riskNegative emotional facesAlcohol use severityYoung adult binge drinkersDefault mode networkFemale binge drinkersAdult binge drinkersEmotional facesHuman Connectome ProjectPublished routinesEmotional tasksAlcohol dependenceGray matter volumes of the superior temporal gyrus link preterm birth and developmentally disordered eye gazing patterns in toddlers at eighteen months
Su Y, Li G, Wang S, Hao D, Li C, Ye-Lin Y, Wang X, Zhang R, Yang L, Li C. Gray matter volumes of the superior temporal gyrus link preterm birth and developmentally disordered eye gazing patterns in toddlers at eighteen months. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2025, 143: 111560. PMID: 41232743, DOI: 10.1016/j.pnpbp.2025.111560.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsPreterm birthGray matter volumeBirth ageSuperior temporal gyriSocial cognitive dysfunctionAutism spectrum disorderCognitive dysfunctionRisk of neurodevelopmental disordersEye gaze patternsMatter volumeNeurodevelopmental disordersBrain changesMonths of agePreterm childrenTotal intracranial volumeMarkers of autism spectrum disorderRight superior temporal gyriBilateral superior temporal gyriPretermInvestigate group differencesIntracranial volumeDysfunctionBirthMonthsHuman Connectome ProjectA randomized pilot sleep and circadian behavior clinical trial to improve glycemic and psychological outcomes in young adults with type 1 diabetes (NCT04975230)
Armentrout B, Wenzell M, Strohl K, Crawford S, Wood J, Li C, Hickman R, Griggs S. A randomized pilot sleep and circadian behavior clinical trial to improve glycemic and psychological outcomes in young adults with type 1 diabetes (NCT04975230). Diabetes & Metabolic Syndrome Clinical Research & Reviews 2025, 19: 103305. PMID: 41110317, PMCID: PMC12595978, DOI: 10.1016/j.dsx.2025.103305.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPsychological outcomesBehavioral sleepYoung adultsAttention control conditionBehavioral clinical trialsPost-interventionAttention control groupCircadian interventionsIntervention conditionDiverse sampleDiabetes distressMean amplitudeMonths post-interventionPreliminary efficacyControl conditionIntervention lengthType 1 diabetesPreliminary findingsSleepCircadian conditionsSleep surveyFollow-upAdultsLonger-term follow-upAmplitude of glucose excursion
Clinical Trials
Current Trials
Biomarkers of Clinical Subtype and Treatment Response in Obsessive-Compulsive Disorder
IRB ID0803003626RoleSub InvestigatorPrimary Completion Date04/19/2025Recruiting ParticipantsGenderBothAge18 years - 70 years
Academic Achievements & Community Involvement
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Activities
activity NIH
07/01/2017 - PresentPeer Review Groups and Grant Study SectionsMember
Honors
honor Fellow, International College of Neuropsychopharmacology
07/01/2019International AwardDetailsUnited Stateshonor Member, American College of Neuropsychopharmacology
12/01/2016International AwardDetailsUnited Stateshonor Fellow, Association of Psychological Science
11/01/2016International AwardDetailsUnited States
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Psychiatry
CMHC S112, 34 Park Street
New Haven, CT 06519
United States