Charlotte Goldfine, MD
Assistant Professor of Emergency MedicineCards
About
Research
Publications
2026
Feasibility, acceptability, and user perspective of a next-generation wrist-worn receiver and digital pills for HIV pre-exposure prophylaxis: a pilot study
Nimbalkar D, Goodman G, Hokayem J, Albrechta H, Loo L, Lee J, Goldfine C, O’Cleirigh C, Mayer K, Alpert P, Carnes C, Chai P. Feasibility, acceptability, and user perspective of a next-generation wrist-worn receiver and digital pills for HIV pre-exposure prophylaxis: a pilot study. Frontiers In Psychiatry 2026, 17: 1550058. PMID: 42221321, PMCID: PMC13220399, DOI: 10.3389/fpsyt.2026.1550058.Peer-Reviewed Original ResearchDigital pill systemSystem Usability ScalePre-exposure prophylaxisPill countHIV pre-exposure prophylaxisSystem Usability Scale scoreStudy periodFollow-up visitMeasures of adherenceProspective cohort studyHIV PrEPPrEP adherenceQualitative feedbackFollow-upQualitative interviewsCohort studyWeekly engagementPrimary outcomeStudy visitsSecondary outcomesUsability ScaleIngestible Sensor SystemPrEPParticipantsAdherence
2025
Challenges of enrolling participants with alcohol and opioid use disorders in the emergency department for clinical trials of ketamine: The experience from two randomized controlled trials
Chai P, Lee E, Hasdianda M, Bianchi M, Campbell D, Goldfine C, Suzuki J. Challenges of enrolling participants with alcohol and opioid use disorders in the emergency department for clinical trials of ketamine: The experience from two randomized controlled trials. General Hospital Psychiatry 2025, 98: 159-164. PMID: 41468673, PMCID: PMC12801413, DOI: 10.1016/j.genhosppsych.2025.12.019.Peer-Reviewed Original ResearchConceptsOpioid use disorderUse disorderEmergency departmentTreatment of alcoholismPreliminary efficacyEfficacy of ketamineApplications of psychedelicsClinical trialsED patientsTreated with ketamineSafety of ketamineKetamine trialsStudy 1Study 2Ketamine infusionSubstance usePsychiatric careRelated trialsRandomized Controlled TrialsKetamineAssociated complaintsPsychedelicsDisordersAcademic EDOpioidAlcohol-related encounter surveillance using emergency medical service records in Massachusetts, 2013–2023
Bettano A, Ficks R, Gonzales G, Blackburn M, Suzuki J, Chai P, Bernson D, Goldfine C, Burstein J. Alcohol-related encounter surveillance using emergency medical service records in Massachusetts, 2013–2023. Drug And Alcohol Dependence 2025, 275: 112819. PMID: 40774183, DOI: 10.1016/j.drugalcdep.2025.112819.Peer-Reviewed Original ResearchConceptsEmergency medical servicesAlcohol-related encountersAlcohol withdrawalEMS encountersAlcohol useEmergency medical services recordsEmergency medical services encountersEmergency medical service callSymptoms of alcohol withdrawalMedical service recordsAlcohol-related wordsAlcohol use indicatorsMedical servicesRecord information systemMedical recordsSelf-ReportService recordsUse indicatorsCOVID-19 pandemicSymptomsWithdrawalLegal substanceEncountersMassachusettsUnited StatesRandomized Trial of Self-Selected Music Intervention on Pain and Anxiety in Emergency Department Patients with Musculoskeletal Back Pain
Goldfine C, Wilson J, Kaithamattam J, Hasdianda M, Mancey K, Rehding A, Schreiber K, Chai P, Weiner S. Randomized Trial of Self-Selected Music Intervention on Pain and Anxiety in Emergency Department Patients with Musculoskeletal Back Pain. Western Journal Of Emergency Medicine 2025, 0: 1112-1119. PMID: 40795020, PMCID: PMC12342572, DOI: 10.5811/westjem.34871.Peer-Reviewed Original ResearchConceptsPost-intervention anxietyMusculoskeletal back painPost-interventional painSelf-selected musicBack painPain severityEmergency departmentPain catastrophizingMusic groupPatient-selected musicFrequent cause of emergency departmentCause of emergency departmentHigher pain catastrophizingAcute back painMediation analysisTrait pain catastrophizingBriefing sessionEmergency department patientsRandomized Controlled TrialsGroup differencesMusic interventionRandomized trialsPost-interventionIntervention groupPsychosocial factorsPhosphatidylethanol levels and their association with withdrawal severity among individuals with severe alcohol use disorder seeking inpatient withdrawal management
Lee J, Szpak V, Vercollone L, Chai P, Goldfine C, Maddams S, Suzuki J. Phosphatidylethanol levels and their association with withdrawal severity among individuals with severe alcohol use disorder seeking inpatient withdrawal management. Frontiers In Psychiatry 2025, 16: 1567617. PMID: 40585542, PMCID: PMC12202389, DOI: 10.3389/fpsyt.2025.1567617.Peer-Reviewed Original ResearchAlcohol Use Disorders Identification TestInpatient withdrawal managementAlcohol withdrawal severityHeavy drinking daysWithdrawal severityWithdrawal managementPEth levelsDrinking daysPercentage of heavy drinking daysPatients' alcohol consumptionPercent heavy drinking daysSevere alcohol use disorderHistory of delirium tremensHistory of withdrawal seizuresAlcohol use disorderAlcohol withdrawal treatmentAlcohol consumptionDisorders Identification TestAverage daily alcohol consumptionConsistent with prior reportsUse disorderWithdrawal seizuresAverage drinksDaily alcohol consumptionHeavy drinkingPatient Perceptions on Opioid Therapy for Acute Pain Management in the Emergency Department and Post-Surgical Settings: A Qualitative Study
Lucey E, Dean E, Chapman B, Perugini R, Chai P, Goldfine C, Carreiro S. Patient Perceptions on Opioid Therapy for Acute Pain Management in the Emergency Department and Post-Surgical Settings: A Qualitative Study. Journal Of Pain Research 2025, 18: 2961-2972. PMID: 40534618, PMCID: PMC12175964, DOI: 10.2147/jpr.s518088.Peer-Reviewed Original ResearchPatient's unique experienceOpioid therapyAcute painSemi-structured interviewsOpioid use disorderEmergency departmentResponse to opioid therapyPlan of careDevelopment of opioid use disorderDays of hospital dischargePost-surgical settingAcute pain managementGeneral surgery clinicPatient experienceNon-therapeutic effectsPatients' perceptionsIndependent codersOpioid toleranceThematic analysisOpioid analgesiaOpioid usePain managementQualitative studyOpioid prescribingParent studyOccult bromazolam exposure in patients presenting with opioid or stimulant overdose
Cembellin-Kao A, Aldy K, Brent J, Culbreth R, LaBozzetta C, Turcios M, Wax P, Yonamine C, Stolbach A, Abston S, Buchanan J, Campleman S, Chary M, Falise A, Ford J, Goldfine C, Hendrickson R, Jang D, Jorgenson D, King A, Lebin J, Levine M, Liss D, Mazer-Amirshahi M, Marlin M, McCabe D, Monte A, Nguyen H, Olives T, Perrone J, Pizon A, Schwarz E, Smollin C, Spyres M, Krotulski A, Logan B. Occult bromazolam exposure in patients presenting with opioid or stimulant overdose. Journal Of Toxicology Clinical Toxicology 2025, 63: 330-336. PMID: 40387680, DOI: 10.1080/15563650.2025.2490831.Peer-Reviewed Original ResearchConceptsCase seriesAcute overdoseDrug useAdmitted to hospitalStimulant overdosePatterns of drug useLiquid chromatography quadrupole time-of-flight mass spectrometrySelf-reported exposureClinical outcomesElectronic medical recordsMedical chartsCritical care unitsClinical dataExcessive sedationAdvanced pregnancyProlonged sedationPatient historyMulti-centerCare unitDrug supplyPatientsMedical recordsCases of sedationLiquid chromatography-tandem quadrupole mass spectrometryQuadrupole time-of-flight mass spectrometryWelcome to the 2025 ACMT Annual Scientific Meeting
Goldfine C, Carpenter J, Mazer-Amirshahi M, Dunavin A, Abston S. Welcome to the 2025 ACMT Annual Scientific Meeting. Journal Of Medical Toxicology 2025, 21: 112-113. PMID: 40000580, PMCID: PMC11933485, DOI: 10.1007/s13181-025-01064-x.Peer-Reviewed Original Research
2024
Occupational, environmental, and toxicological health risks of mining metals for lithium-ion batteries: a narrative review of the Pubmed database
Brown C, Goldfine C, Allan-Blitz L, Erickson T. Occupational, environmental, and toxicological health risks of mining metals for lithium-ion batteries: a narrative review of the Pubmed database. Journal Of Occupational Medicine And Toxicology 2024, 19: 35. PMID: 39192280, PMCID: PMC11348589, DOI: 10.1186/s12995-024-00433-6.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsWelcome to the 2024 ACMT Annual Scientific Meeting
Toce M, Goldfine C, Mazer-Amirshahi M, Meyn A. Welcome to the 2024 ACMT Annual Scientific Meeting. Journal Of Medical Toxicology 2024, 20: 84-85. PMID: 38409481, PMCID: PMC10959871, DOI: 10.1007/s13181-024-00992-4.Commentaries, Editorials and Letters
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