Caleigh Mandel-Brehm, PhD

My research seeks to advance understanding of the molecular and cellular underpinnings of basic neuro-immune interactions and associated human autoimmune pathology.

I did my PhD training at Harvard Medical School under the guidance of Dr. Michael Greenberg in molecular neuroscience and behavior. I broadened my experience during my postdoc with Dr. Joseph DeRisi at UCSF where I built molecular tools to study autoimmune responses in humans with idiopathic neurological disorder. My prior training places my lab in a unique position to tackle the outstanding questions in autoimmune pathologies in the central nervous system. In addition to basic research, I will continue a translational research program that will provide findings that can bridge bench and bedside (see link).

Interactions between the nervous system and immune system are intricate and critical for normal brain function. Aberrant interactions can result in severe consequences, often breaking tolerance to self-proteins and causing autoimmunity, which in turn causes diverse symptoms of behavioral and movement disorders and even psychiatric illness. Despite the allure of studying this intriguing network of cells, involving two different systems, remarkably, little is known regarding how immune cells enter the brain and cause specific regions of neuronal dysfunction.

Mentorship and training the next generation of scientists is a priority for my lab. I benefited from strong mentoring beginning in undergraduate and I understand the importance of guidance and encouragement. Beyond training in research, mentoring through scientific writing, critical review of scientific journal articles, and seminar presentations both at Yale and relevant scientific meetings, will provide visibility and preparation for a career in academia or industry.

​My lab is located in the Department of Pathology which is a vibrant scientific community studying mechanisms of cancer and autoimmune disease.

All motivated folks of diverse backgrounds and interests are encouraged to apply.

https://www.name-coach.com/caleigh-mandel-brehm