Brian Pittman
Statistician 3Cards
About
Research
Publications
2025
Effects of Age and BMI on Histamine H3 Receptor Availability in Healthy Humans
Yang Y, Ibrahim W, Gravel P, Pittman B, Hoye J, Cool R, Sadabad F, Zheng M, Pittenger C, Gallezot J, Carson R, Huang H, Radhakrishnan R, Matuskey D. Effects of Age and BMI on Histamine H3 Receptor Availability in Healthy Humans. Molecular Imaging And Biology 2025, 27: 832-838. PMID: 40938339, DOI: 10.1007/s11307-025-02047-8.Peer-Reviewed Original ResearchHigh-resolution research tomographBody mass indexPositron emission tomographyEffects of ageAnterior cingulate cortexPotential confounding effects of ageAge-related declineTwo-tissue compartment modelCingulate cortexReceptor availabilityFrontal cortexParietal cortexOlfactory cortexSubcortical regionsHealthy humansRegional VTCortexConfounding effects of ageCerebellum cortexEmission tomographyTwo-tissueMass indexHealthy individualsInsulaAssessed alterationsBrain white matter microstructure in middle and older aged adults with bipolar disorder: a two-site study
Sankar A, Colic L, Marks R, Rajashekar N, Pittman B, Constable R, Sajatovic M, Eyler L, Blumberg H. Brain white matter microstructure in middle and older aged adults with bipolar disorder: a two-site study. American Journal Of Geriatric Psychiatry 2025 DOI: 10.1016/j.jagp.2025.09.013.Peer-Reviewed Original ResearchBipolar disorderEmotion regulationFractional anisotropyUncinate fasciculusWM microstructureCorpus callosumWM fractional anisotropyBrain white matter microstructureWhite matter microstructureAnterior corpus callosumTwo-site studyPosterior corpus callosumOlder aged adultsMood symptomsConsistent with findingsWhite matterNeurodevelopmental alterationsOlder adulthoodStudy of adults ageWM tractsCognitive impairmentLow FAEffect sizeAge interactionOlder adultsA Prospective Assessment of Weight Bias Internalization in Patients Seeking Body Contouring after Bariatric Surgery
Dunford A, Metzler A, Ivezaj V, Pittman B, Alperovich M, Price G. A Prospective Assessment of Weight Bias Internalization in Patients Seeking Body Contouring after Bariatric Surgery. Surgery For Obesity And Related Diseases 2025 PMID: 40940272, DOI: 10.1016/j.soard.2025.06.020.Peer-Reviewed Original ResearchEating-disorder psychopathologyWeight bias internalizationDepressive symptomsAssociated with greater eating-disorder psychopathologyAssociated with eating-disorder psychopathologyHigher weight bias internalizationBody contouring surgeryBody mass indexMental health concernsBariatric surgeryPsychopathologyGroup differencesFollow-upSignificant groupBody imageProspective analysisProspective assessmentTime interactionIndependent of body mass indexWeight lossSymptomsUnited States METHODSContouring surgeryParticipantsBariatric teamThe Role of Childhood Trauma in Chronic Pain and Substance Use Among Individuals Receiving Methadone Treatment for Opioid Use Disorder.
Costa G, Ra J, Meyerovich J, Pittman B, C Nunes J, De Aquino J. The Role of Childhood Trauma in Chronic Pain and Substance Use Among Individuals Receiving Methadone Treatment for Opioid Use Disorder. Journal Of Addiction Medicine 2025 PMID: 40728216, DOI: 10.1097/adm.0000000000001553.Peer-Reviewed Original ResearchOpioid use disorderChildhood Trauma QuestionnaireChildhood traumaSubstance useCannabis initiationUse disorderBrief Pain InventoryEmotional abuseAge of cannabis initiationPain severityChronic painHigher childhood trauma scoresHistory of childhood traumaLikelihood of cannabis useLevels of emotional abuseChildhood trauma exposureChildhood trauma scoresTrauma-focused assessmentAlcohol consumptionHigher alcohol useOpioid use disorder treatment programsTrauma exposureTrauma QuestionnaireCannabis useTrauma subscalesInteractions of alcohol and the benzodiazepine inverse agonist in healthy male volunteers
Singh N, Petrakis I, Pittman B, Luddy C, Krystal J, DSouza D. Interactions of alcohol and the benzodiazepine inverse agonist in healthy male volunteers. Journal Of Psychopharmacology 2025, 39: 715-725. PMID: 40673436, DOI: 10.1177/02698811251330746.Peer-Reviewed Original ResearchConceptsBenzodiazepine partial inverse agonistPartial inverse agonistGABA-A receptorsEthanol intoxicationInverse agonistsGABA-ASedative effectsSedative effects of alcoholAlcohol intoxicationEffects of alcohol intoxicationBenzodiazepine inverse agonistGABA-A receptor subtypesHealthy male volunteersExtrasynaptic GABA-A receptorsWithin-subject designEffects of alcoholStandard alcoholic drinksInteraction of alcoholAffect ScaleAlcohol effectsGABAergic modulationMale volunteersIntravenous alcoholBenzodiazepinesAlcohol drinkingUsing the excitation/inhibition ratio to optimize the classification of autism and schizophrenia
Uscătescu L, Hyatt C, Dunn J, Kronbichler M, Calhoun V, Corbera S, Pelphrey K, Pittman B, Pearlson G, Assaf M. Using the excitation/inhibition ratio to optimize the classification of autism and schizophrenia. Translational Psychiatry 2025, 15: 234. PMID: 40634290, PMCID: PMC12241497, DOI: 10.1038/s41398-025-03455-8.Peer-Reviewed Original ResearchConceptsAutism Diagnostic Observation ScheduleBermond-Vorst Alexithymia QuestionnaireEmpathy QuotientE/I ratioResting state fMRI dataClassification of autismReplication datasetAlexithymia QuestionnairePANSSSchizophreniaObservation ScheduleFMRI dataGroup differencesAutismExcitation/inhibition ratioIQE/IHurst (H) exponentRandom forest classifierExcitation/inhibitionTDClassification performanceTime courseClassification analysisExploratory datasetAlcohol use during pregnancy: the impact of social determinants of health on alcohol consumption among pregnant women
Peltier M, Verplaetse T, Bici V, Mokwuah A, Chavez C, Zakiniaeiz Y, Kohler R, Garcia-Rivas V, Banini B, Zhou H, Raval N, Pittman B, McKee S. Alcohol use during pregnancy: the impact of social determinants of health on alcohol consumption among pregnant women. Biology Of Sex Differences 2025, 16: 49. PMID: 40598644, PMCID: PMC12219128, DOI: 10.1186/s13293-025-00731-6.Peer-Reviewed Original ResearchConceptsSocial determinants of healthDeterminants of healthImpact of SDoHMonthly binge drinkingMonth alcohol useAlcohol useLikelihood of alcohol useSocial determinantsLikelihood of binge drinkingPregnant womenBinge drinkingImpact of social determinants of healthAlcohol consumptionNational Survey of Drug Use and HealthNational surveyMethodsCross-sectional dataDrug Use and HealthRates of prenatal alcohol exposureHigh school educationCriminal justice involvementPast-month alcohol useHealthcare providersSDOHTime of alcohol consumptionPrenatal alcohol exposurePain interference, alcohol use, and metabolic health: Insights from a nationally representative study
Costa G, Suh R, Nunes J, Pittman B, Sofuoglu M, Petrakis I, De Aquino J. Pain interference, alcohol use, and metabolic health: Insights from a nationally representative study. Alcohol Clinical And Experimental Research 2025, 49: 1768-1777. PMID: 40568749, DOI: 10.1111/acer.70108.Peer-Reviewed Original ResearchConceptsNational Health and Nutrition Examination SurveyPain interferenceHeavy alcohol useAlcohol usePhysical activityHealth and Nutrition Examination SurveyMetabolic dysfunctionSleep durationNutrition Examination SurveyQuasi-Poisson regression modelCross-sectional analysisTherapeutic approachesComplex patient populationHours of sleepExamination SurveyUS adultsPrimary exposureSecondary analysisChronic painMetabolic healthInteractive associationsClinical outcomesPathophysiological domainsHigher TyGPatient populationCognitive bias modification for individuals with opioid use disorder and chronic pain did not predict changes in clinical outcomes.
Wolkowicz N, Pittman B, Schrader S, Wesolowicz D, Sofuoglu M, Heapy A, MacLean R. Cognitive bias modification for individuals with opioid use disorder and chronic pain did not predict changes in clinical outcomes. Journal Of Studies On Alcohol And Drugs 2025 PMID: 40536409, PMCID: PMC12569794, DOI: 10.15288/jsad.25-00057.Peer-Reviewed Original ResearchCognitive bias modificationAttentional biasOpioid cravingBias modificationCBM effectsSubstance use disordersPain severityChronic painClinical outcomesAddiction severityOpioid use disorderUse disorderNaturalistic settingsNeutral-cueOpioid withdrawalPain cuesCravingDiverse sampleSalient outcomesSubstance typePreliminary effectivenessPrimary clinical outcomePain catastrophizingModerate painPain intensityGreater neuroimmune system deficit in women than men with alcohol use disorder
Zakiniaeiz Y, Hillmer A, Shi H, Pittman B, Nabulsi N, Huang Y, Bonomi R, Matuskey D, Angarita G, McKee S, Cosgrove K. Greater neuroimmune system deficit in women than men with alcohol use disorder. Biological Psychiatry 2025 PMID: 40412787, PMCID: PMC12353993, DOI: 10.1016/j.biopsych.2025.05.012.Peer-Reviewed Original ResearchTranslocator protein availabilityAlcohol-induced neurodegenerationExecutive function tasksConsequences of alcohol useAlcohol use disorderBrain imaging scansTranslocator protein levelsSex-matched controlsExecutive functionLower hippocampalTSPO availabilityFrontal cortexTranslocator proteinUse disorderNeurocognitive functionBrain regionsSex differencesAlcohol useBrain-resident immune cellsNeuroimmune mechanismsFunctional tasksSystem deficitsAUDImaging scansNeuroimmune cells
News
News
- July 29, 2025Source: Journal of Addiction Medicine
The Role of Childhood Trauma in Chronic Pain and Substance Use Among Individuals Receiving Methadone Treatment for Opioid Use Disorder
- June 26, 2025Source: Alcohol, Clinical and Experimental Research
Pain Interference, Alcohol Use, and Metabolic Health: Insights From a Nationally Representative Study
- February 20, 2025Source: BMJ Mental Health
Chronotherapeutic Intervention Targeting Emotion Regulation Brain Circuitry, Symptoms, and Suicide Risk in Adolescents and Young adults With Bipolar Disorder: A Pilot Randomised Trial
- October 16, 2024Source: Biological Psychiatry
Vitamin D’s Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [11C]-PHNO Positron Emission Tomography Study