Brandon Chou
Hospital ResidentAbout
Research
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Featured Publications
Evaluating Photochemical Interactions Between Rose Bengal Photodynamic Antimicrobial Therapy and Topical Antifungals in Fungal Keratitis Isolates
Krishna K, Chou B, Gonzalez L, Durkee H, Paudyal S, Ahmed A, Tribin F, Ferreira B, Lai J, Aguilar M, Arboleda A, Leblanc R, Flynn H, Amescua G, Parel J, Miller D. Evaluating Photochemical Interactions Between Rose Bengal Photodynamic Antimicrobial Therapy and Topical Antifungals in Fungal Keratitis Isolates. Investigative Ophthalmology & Visual Science 2026, 67: 11. PMID: 41533911, PMCID: PMC12798750, DOI: 10.1167/iovs.67.1.11.Peer-Reviewed Original ResearchConceptsAspergillus isolatesRB-PDATAmphotericin BPhotodynamic antimicrobial therapyClinical isolatesCombination therapyIsolates of Fusarium sppAntifungal stabilityGrowth inhibitionAntifungal monotherapyTopical antifungalsAntimicrobial therapyConcentrations of amphotericin BResponse to antifungalsStrain-specific effectsFusarium isolatesFusarium sppFungal inhibitionAgar platesIn vitro effectsVoriconazoleAntifungalsMicrobiological techniquesAspergillusFusariumTrends in utilization of imaging among ophthalmic-related emergency department visits in the United States
Chou B, Shah S, Kalavar M, Sridhar J, MacIntosh P, Lee A. Trends in utilization of imaging among ophthalmic-related emergency department visits in the United States. Frontiers In Ophthalmology 2026, 5: 1706213. PMID: 41647930, PMCID: PMC12867896, DOI: 10.3389/fopht.2025.1706213.Peer-Reviewed Original ResearchMagnetic resonance imagingNational Hospital Ambulatory Medical Care SurveyComputed tomographyAverage annual percent changeLikelihood of imagingCT usageED visitsEmergency departmentMagnetic resonance imaging useNeuro-ophthalmic conditionsMagnetic resonance imaging utilizationAdvanced imaging studiesMultivariate logistic regressionAdvanced imaging useAnnual percent changeNational trendsU.S. emergency departmentsEmergency department visitsCOVID-19 pandemicImaging useRetrospective trend studyImaging studiesResonance imagingPercent changeNeuroimaging useClinical Outcomes of Conjunctival Flap Surgery for Refractory Infectious Keratitis: A Retrospective Case Series.
Llaneras C, Chou B, Quintana I, Huang J, Correa J, Durkee H, Galor A, Amescua G, Miller D, Martinez J. Clinical Outcomes of Conjunctival Flap Surgery for Refractory Infectious Keratitis: A Retrospective Case Series. Cornea 2026 PMID: 41650351, DOI: 10.1097/ico.0000000000004116.Peer-Reviewed Original ResearchRefractory infectious keratitisConjunctival flap surgeryKaplan-Meier survival analysisInfectious keratitisConjunctival flapClinical outcomesPartial flapSurgical successInfection resolutionFlap surgeryCase seriesBest-corrected visual acuityBascom Palmer Eye InstituteFlap casesSingle-center case seriesAssociated with flap failureSurvival analysisPartial conjunctival flapLog-rank testRetrospective case seriesTertiary care centerWilcoxon testLarger ulcer areaProcedural Terminology codesGeneralized Wilcoxon testPhotodynamic antimicrobial therapy with Erythrosin B, Eosin Y, and Rose Bengal for the inhibition of fungal keratitis isolates: An in vitro study
Chou B, Krishna K, Durkee H, Tribin F, Ahmed A, Lai J, Aguilar M, Ferreira B, Leblanc R, Flynn H, Amescua G, Parel J, Miller D. Photodynamic antimicrobial therapy with Erythrosin B, Eosin Y, and Rose Bengal for the inhibition of fungal keratitis isolates: An in vitro study. Journal Of Photochemistry And Photobiology B Biology 2024, 263: 113090. PMID: 39752999, PMCID: PMC12320518, DOI: 10.1016/j.jphotobiol.2024.113090.Peer-Reviewed Original ResearchConceptsPhotodynamic antimicrobial therapyFungal keratitisOcular isolatesAntimicrobial therapyCases of fungal keratitisDeep fungal infectionsTissue penetrationAspergillus sppFungal isolatesIn vitro studiesCorneal blindnessAntifungal treatmentKeratitis isolatesTreatment modalitiesFungal infectionsKeratitisFusarium solani strainsFungal growth inhibitionAntimicrobial efficacyInhibitory effectTherapyGrowth inhibitionInhibitionAgar platesEfficacyAlternative photosensitizer penetration depth evaluation in ex vivo human eyes for photodynamic antimicrobial therapy
Lai J, Krishna K, Chou B, Chen J, Rowley K, Navia J, Durkee H, Aguilar M, Llanes K, Ziebarth N, Martinez J, Miller D, Flynn H, Amescua G, Parel J. Alternative photosensitizer penetration depth evaluation in ex vivo human eyes for photodynamic antimicrobial therapy. Therapeutic Delivery 2025, 16: 519-526. PMID: 40241254, PMCID: PMC12140472, DOI: 10.1080/20415990.2025.2491293.Peer-Reviewed Original ResearchConceptsPhotodynamic antimicrobial therapyAntimicrobial therapyAlternative photosensitizersEx vivo human eyeCorneal safetyRB-PDATFungal keratitisCorneal stromaRefractory casesHuman corneaNo significant differencePoor prognosisAdjunctive treatmentClinical usePoor penetrationSignificant differenceCornealCorneaAntimicrobial efficacyTherapyConfocal microscopySuperior penetrationHuman eyeKeratitisPrognosisAPPLICATIONS OF MULTIMODAL GENERATIVE ARTIFICIAL INTELLIGENCE IN A REAL-WORLD RETINA CLINIC SETTING
Ghalibafan S, Gonzalez D, Cai L, Chou B, Panneerselvam S, Barrett S, Djulbegovic M, Yannuzzi N. APPLICATIONS OF MULTIMODAL GENERATIVE ARTIFICIAL INTELLIGENCE IN A REAL-WORLD RETINA CLINIC SETTING. Retina 2024, 44: 1732-1740. PMID: 39287535, DOI: 10.1097/iae.0000000000004204.Peer-Reviewed Original ResearchConceptsNonexudative age-related macular degenerationAge-related macular degenerationPosterior vitreous detachmentMacular degenerationRetinal detachmentVitreous detachmentGroup ACentral retinal vein occlusionInternational ClassificationRetinal vein occlusionRetrospective cross-sectional studyInternational Classification of Diseases 10th Revision codesMacular holeCross-sectional studyRetina specialistsVein occlusionVitreoretinal diseasesEye clinicOphthalmology settingNo significant differenceGroup BDiagnostic accuracyInternational Classification of Diseases 10th RevisionPatient groupPatientsLight Filtering Lenses and Visual Photosensitivity in Individuals With Traumatic Brain Injury.
Aguilar M, Durkee H, Gonzalez A, Lai J, Chou B, Valdes Arias D, Patel S, Echeverri Tribin F, Bhatt S, Rowaan C, Alvarez G, Hurwitz B, Lam B, Felix E, Parel J, Galor A. Light Filtering Lenses and Visual Photosensitivity in Individuals With Traumatic Brain Injury. Investigative Ophthalmology & Visual Science 2026, 67: 46. PMID: 41729042, PMCID: PMC12934528, DOI: 10.1167/iovs.67.2.46.Peer-Reviewed Original ResearchConceptsVisual photosensitivity thresholdsNo lensPlano lensesFilter lensesTraumatic brain injuryEffective treatment optionAcademic tertiary centerLens conditionNon-TBI controlsFL-41Brain injuryTertiary centerTreatment optionsCohort studyInitial visitVisual photosensitivityTraumatic brain injury sequelaePL conditionVisitsInjuryParameter-Dependent Effects of Rose Bengal Photodynamic Antimicrobial Therapy on MRSA Inhibition and Corneal Cytokine Expression
Arboleda A, Durkee H, Aguilar M, Maestre-Mesa J, Tribin F, Chou B, Relhan N, Nolan N, Rowaan C, Gonzalez A, Alawa K, Flynn H, Amescua G, Parel J, Miller D. Parameter-Dependent Effects of Rose Bengal Photodynamic Antimicrobial Therapy on MRSA Inhibition and Corneal Cytokine Expression. Translational Vision Science & Technology 2026, 15: 14. PMID: 41983771, PMCID: PMC13094781, DOI: 10.1167/tvst.15.4.14.Peer-Reviewed Original ResearchConceptsMethicillin-resistant Staphylococcus aureusPhotodynamic antimicrobial therapyCytokine responsesAntimicrobial therapyParameter-dependent effectsHealth care-associated methicillin-resistant Staphylococcus aureusMRSA inhibitionMethicillin-resistant Staphylococcus aureus strainsClinical methicillin-resistant Staphylococcus aureusIL-8IL-6Clinical MRSA isolatesCorneal epithelial cellsIL-8 expressionPhotosensitizer concentrationColony-forming units/mlMRSA isolatesMicrobial keratitisEffective antimicrobial strategiesHigher photosensitizer concentrationsCytokine productionCytokine expressionEpithelial modelEpithelium modelInflammatory cytokinesClinical Features and Treatment Outcomes of Carbapenem-Resistant Pseudomonas aeruginosa Keratitis
Tribin F, Lieux C, Maestre-Mesa J, Durkee H, Krishna K, Chou B, Neag E, Tóthová J, Martinez J, Flynn H, Parel J, Miller D, Amescua G. Clinical Features and Treatment Outcomes of Carbapenem-Resistant Pseudomonas aeruginosa Keratitis. JAMA Ophthalmology 2024, 142: 407-415. PMID: 38512246, PMCID: PMC10958388, DOI: 10.1001/jamaophthalmol.2024.0259.Peer-Reviewed Original ResearchConceptsRB-PDATIn vitro efficacyP aeruginosaIn vivo outcomesCase seriesDisease progressionMultidrug-resistant P aeruginosaRetrospective observational case seriesTreatment outcomesBascom Palmer Eye InstituteAdjuvant to antibiotic therapyResistance to carbapenemsObservational case seriesSusceptibility to antibioticsPositive test resultsMultidrug-resistant microbesMinimum inhibitory concentration testBlaGES genesVisual outcomeEye InstituteAntibiotic therapyAntimicrobial therapyInhibitory concentration testClinical featuresRecalcitrant casesNeuropsychological influences on visual photosensitivity and its treatment in traumatic brain injury
Bhatt S, Chou B, Li S, Aguilar M, Durkee H, Gonzalez A, Lai J, Valdes-Arias D, Patel S, Rowaan C, Tribin F, Alvarez G, Hurwitz B, Lam B, Felix E, Parel J, Galor A. Neuropsychological influences on visual photosensitivity and its treatment in traumatic brain injury. BMJ Open Ophthalmology 2026, 11: e002510. PMID: 42014170, PMCID: PMC13110607, DOI: 10.1136/bmjophth-2025-002510.Peer-Reviewed Original ResearchConceptsVisual photosensitivity thresholdsHigher PHQ-9 scoresPatient Health Questionnaire-9PHQ-9 scoresTraumatic brain injuryPlano lensNeuropsychological factorsBrief testBrief Test of Adult CognitionTraumatic brain injury groupBrain injuryPain catastrophisingVisual photosensitivityOrdinal regression modelLower cognitionShort formAdult cognitionMultivariate linearZ-scoreRegression modelsOrdinal regressionVersion 2CognitionScoresFL-41