Bethany Nelson, ACNP (BC), APRN
Staff Affiliate - YNHHCards
About
Research
Publications
2022
Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617
Peng L, Hu Y, Mankowski MC, Ren P, Chen RE, Wei J, Zhao M, Li T, Tripler T, Ye L, Chow RD, Fang Z, Wu C, Dong MB, Cook M, Wang G, Clark P, Nelson B, Klein D, Sutton R, Diamond MS, Wilen CB, Xiong Y, Chen S. Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617. Nature Communications 2022, 13: 1638. PMID: 35347138, PMCID: PMC8960874, DOI: 10.1038/s41467-022-29288-3.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Authentic SARS-CoV-2Effective therapeutic optionPotent SARS-CoV-2SARS-CoV-2 variantsVariants of concernRepertoire of therapeuticsBreakthrough infectionsTherapeutic optionsMultiple vaccinesPathogen SARS-CoV-2Delta variantB cellsPotent efficacyHumanized antibodyDistinct epitopesBispecific antibodiesOriginal virusSpike receptorStrong inhibitory activityMonoclonal antibodiesAntibodiesStrong potencyLead clonesLead antibodies
2019
Improving Diabetes Control Through Remote Glucose Monitoring in a Diabetes Self-Management Program for Employees of a Health System
Odom J, Stancil M, Nelson B, Russ-Sellers R, Schwecke N, Dawson J, Reulbach L, Burns A, Lindholm M, Bruch J. Improving Diabetes Control Through Remote Glucose Monitoring in a Diabetes Self-Management Program for Employees of a Health System. Clinical Diabetes 2019, 37: 203-210. PMID: 31371850, PMCID: PMC6640876, DOI: 10.2337/cd18-0056.Peer-Reviewed Original ResearchDiabetes self-management programSelf-management programImprove diabetes controlCost of careYears of follow-upDiabetic controlImprove carePhysician providersDiabetes educationHealth systemRemote glucose monitoringPopulation of employeesType 2 diabetesTarget populationMedication algorithmTelehealthCareFollow-upGlucose monitoringDiabetesEducationRemote monitoringProgramProvidersHealth
2018
Employee Health: Diabetes Self-Management with Wireless Meter
BRUCH J, STANCIL M, ODOM J, NELSON B, REULBACH L, RUSS-SELLERS R, BURNS A, LINDHOLM M, DAWSON J, SCHWECKE N. Employee Health: Diabetes Self-Management with Wireless Meter. Diabetes 2018, 67 DOI: 10.2337/db18-651-p.Peer-Reviewed Original ResearchDiabetes educationSelf-management of diabetesGreenville Health SystemPrimary care providersSelf-management behaviorsKnowledge of diabetesPrimary care physiciansImprove patient understandingHealth care systemIncrease adherence ratesMedication algorithmSelf-monitoring behaviorNon-insulin medicationsYears post-enrollmentDiabetes knowledgePCP visitsCare providersImprove careSelf-CareCare physiciansHealthcare professionalsHealth systemPatient understandingCare systemRemote glucose monitoringStructure-Guided Combinatorial Engineering Facilitates Affinity and Specificity Optimization of Anti-CD81 Antibodies
Nelson B, Adams J, Kuglstatter A, Li Z, Harris S, Liu Y, Bohini S, Ma H, Klumpp K, Gao J, Sidhu S. Structure-Guided Combinatorial Engineering Facilitates Affinity and Specificity Optimization of Anti-CD81 Antibodies. Journal Of Molecular Biology 2018, 430: 2139-2152. PMID: 29778602, DOI: 10.1016/j.jmb.2018.05.018.Peer-Reviewed Original ResearchConceptsCD81 large extracellular loopLarge extracellular loopAffinity maturationPhage displayHepatitis C viral infectionExtracellular loopPhage display technologyAnti-CD81 antibodyAffinity maturation of antibodiesSingle-chain variable fragmentChronic hepatitisCombinatorial engineeringMaturation of antibodiesAnimal model testingPhageAntibody developmentTherapeutic antibody developmentAntibodiesCD81Independent antibodiesHepatitisVariable fragmentCross-reactivityAffinity
2013
Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region
Reshetnyak AV, Nelson B, Shi X, Boggon TJ, Pavlenco A, Mandel-Bausch EM, Tome F, Suzuki Y, Sidhu SS, Lax I, Schlessinger J. Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 17832-17837. PMID: 24127596, PMCID: PMC3816449, DOI: 10.1073/pnas.1317118110.Peer-Reviewed Original ResearchConceptsKIT antibodyReceptor tyrosine kinase inhibitionGastrointestinal stromal tumorsAcute myeloid leukemiaDurable disease controlTyrosine kinase inhibitorsTyrosine kinase inhibitionSomatic oncogenic mutationsUnique therapeutic approachClinical progressionStromal tumorsMyeloid leukemiaTherapeutic approachesDramatic responseTreatment of KITDrug resistanceDisease controlIsolated antibodyKIT inhibitionKinase inhibitorsAntibodiesCancerCell proliferationOncogenic mutationsKinase inhibitionRecombinant Genetic Libraries and Human Monoclonal Antibodies
Adams J, Nelson B, Sidhu S. Recombinant Genetic Libraries and Human Monoclonal Antibodies. Methods In Molecular Biology 2013, 1060: 149-170. PMID: 24037841, DOI: 10.1007/978-1-62703-586-6_9.Peer-Reviewed Original ResearchConceptsComplementarity-determining regionsSynthetic antibody librariesHuman proteomeAntibody libraryMammalian immune systemPharmacological reagentsHuman antigen-binding fragmentAntigen-binding fragmentsPhage displaySynthetic antibodiesHybridoma technologyProteomicsSynthetic repertoireHuman monoclonal antibodyDiversityRepertoireHuman frameworkImmune systemMonoclonal antibodiesImmuno-dominantPhageHuman antigensSelection methodologyOligonucleotidesLibrary
2012
Synthetic Antibody Libraries
Nelson B, Sidhu S. Synthetic Antibody Libraries. Methods In Molecular Biology 2012, 899: 27-41. PMID: 22735944, DOI: 10.1007/978-1-61779-921-1_2.Peer-Reviewed Original Research