April Pruitt
About
Research
Publications
2026
Transcriptomic and phenotypic convergence of neurodevelopmental disorder risk genes in vitro and in vivo
Fernandez Garcia M, Retallick-Townsley K, Pruitt A, Davidson E, Balafkan N, Warrell J, Huang T, Kibowen A, Chu Z, Dai Y, Fitzpatrick S, Meng R, Sen A, Cohen S, Livoti O, Khan S, Becker C, Luiz Teles e Silva A, Liu J, Dossou G, Cheung J, Liu S, Ghorbani S, Deans P, DeCiucis M, Emani P, Gao H, Shen H, Gerstein M, Wang Z, Huckins L, Hoffman E, Brennand K. Transcriptomic and phenotypic convergence of neurodevelopmental disorder risk genes in vitro and in vivo. Nature Neuroscience 2026, 29: 1079-1094. PMID: 42032432, PMCID: PMC13156037, DOI: 10.1038/s41593-026-02247-7.Peer-Reviewed Original ResearchPharmaco-behavioral profiling identifies suppressors of autism gene–associated phenotypes in zebrafish
Jamadagni P, Dai Y, Liu Y, Mendes H, Pruitt A, Khan S, Yang L, Huang T, Huang X, Deans P, Balafkan N, Zhao D, Xu G, Liu Y, Li N, Wu W, Fitzpatrick S, Neelakantan U, Chen T, Szialta C, Jin D, Lacadie C, Umlauf S, Papademetris X, Surovtseva Y, Brennand K, Wang Z, Hoffman E. Pharmaco-behavioral profiling identifies suppressors of autism gene–associated phenotypes in zebrafish. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2518846123. PMID: 41838920, PMCID: PMC13012064, DOI: 10.1073/pnas.2518846123.Peer-Reviewed Original Research
2025
Molecular and Genetic Mechanisms in Autism Spectrum Disorder
Pruitt A, Gupta A, Hoffman E. Molecular and Genetic Mechanisms in Autism Spectrum Disorder. Annals Of Neurology 2025, 98: 1163-1177. PMID: 40801227, PMCID: PMC13159706, DOI: 10.1002/ana.70013.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsGeneration of stable brain cell cultures from embryonic zebrafish to interrogate phenotypes in zebrafish mutants of neurodevelopmental disorders
Odierna G, Stednitz S, Pruitt A, Arnold J, Hoffman E, Scott E. Generation of stable brain cell cultures from embryonic zebrafish to interrogate phenotypes in zebrafish mutants of neurodevelopmental disorders. Journal Of Neuroscience Methods 2025, 418: 110426. PMID: 40086601, DOI: 10.1016/j.jneumeth.2025.110426.Peer-Reviewed Original Research
2023
High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways
Mendes H, Neelakantan U, Liu Y, Fitzpatrick S, Chen T, Wu W, Pruitt A, Jin D, Jamadagni P, Carlson M, Lacadie C, Enriquez K, Li N, Zhao D, Ijaz S, Sakai C, Szi C, Rooney B, Ghosh M, Nwabudike I, Gorodezky A, Chowdhury S, Zaheer M, McLaughlin S, Fernandez J, Wu J, Eilbott J, Vander Wyk B, Rihel J, Papademetris X, Wang Z, Hoffman E. High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways. Cell Reports 2023, 42: 112243. PMID: 36933215, PMCID: PMC10277173, DOI: 10.1016/j.celrep.2023.112243.Peer-Reviewed Original Research