Amos Espinosa
he/him/his
About
Research
Publications
2025
RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and Wnt pathway activation
Mayday M, Biancon G, Wei M, Ramirez C, Moratti I, Pintado-Urbanc A, Espinosa J, Chen M, Wang L, Simon M, Ofir-Rosenfeld Y, Rausch O, Tebaldi T, Halene S, Krause D. RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and Wnt pathway activation. Blood 2025, 146: 1096-1109. PMID: 40435410, DOI: 10.1182/blood.2024027712.Peer-Reviewed Original ResearchRNA fateM6A modificationFusion proteinWnt pathway activationFrizzled genesFunctions of RBM15Dysregulation of m6A modificationRBM15-MKL1Pathway activationMulti-omics approachInduced apoptosis in vitroWnt Signaling PathwayApoptosis in vitroM6A depositionRNA bindingSpecific RNAGrowth in vitroM6A methylationMRNA targetsSignaling pathwayWnt pathwayWnt signalingM6A modifiersM6A-dependent mechanismRNA
2021
Reimagining dots and dashes: Visualizing structure and function of organelles for high-content imaging analysis.
Chin MY, Espinosa JA, Pohan G, Markossian S, Arkin MR. Reimagining dots and dashes: Visualizing structure and function of organelles for high-content imaging analysis. Cell Chemical Biology 2021, 28: 320-337. PMID: 33600764, PMCID: PMC7995685, DOI: 10.1016/j.chembiol.2021.01.016.Peer-Reviewed Original ResearchReal-Time Assessment of Mitochondrial Toxicity in HepG2 Cells Using the Seahorse Extracellular Flux Analyzer.
Espinosa JA, Pohan G, Arkin MR, Markossian S. Real-Time Assessment of Mitochondrial Toxicity in HepG2 Cells Using the Seahorse Extracellular Flux Analyzer. Current Protocols 2021, 1: e75. PMID: 33735523, DOI: 10.1002/cpz1.75.Peer-Reviewed Original Research
2020
Multiparametric High-Content Assays to Measure Cell Health and Oxidative Damage as a Model for Drug-Induced Liver Injury.
Pohan G, Espinosa JA, Chen S, Ang KK, Arkin MR, Markossian S. Multiparametric High-Content Assays to Measure Cell Health and Oxidative Damage as a Model for Drug-Induced Liver Injury. Current Protocols In Chemical Biology 2020, 12: e90. PMID: 33315311, PMCID: PMC8269189, DOI: 10.1002/cpch.90.Peer-Reviewed Original Research