Akhil Khosla, MD
Assistant ProfessorDownloadHi-Res Photo
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Additional Titles
Director, Pulmonary Embolism Response Team (PERT), Yale New Haven Health System
Chair, Cardiac Arrest and Rapid Response Committee, Yale New Haven Health System
Chair, System Airway Lead, YNHHS
Chair, Resuscitation, Code and Rapid Response Team Committee, Yale-New Haven Hospital
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Titles
Assistant Professor
Director, Pulmonary Embolism Response Team (PERT), Yale New Haven Health System; Chair, Cardiac Arrest and Rapid Response Committee, Yale New Haven Health System; Chair, System Airway Lead, YNHHS; Chair, Resuscitation, Code and Rapid Response Team Committee, Yale-New Haven Hospital
Appointments
Pulmonary, Critical Care & Sleep Medicine
Assistant ProfessorPrimary
Other Departments & Organizations
- All Institutions
- Internal Medicine
- Pulmonary Vascular Disease Program
- Pulmonary, Critical Care & Sleep Medicine
- Yale Medicine
- Yale New Haven Health System
Education & Training
- Fellow
- Yale School of Medicine (2019)
- Fellow
- Norwalk Hospital (2018)
- Resident
- Norwalk Hospital (2016)
- Internship
- Norwalk Hospital (2014)
- MD
- St. George's University School of Medicine (2013)
Research
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Overview
Medical Research Interests
Out-of-Hospital Cardiac Arrest; Pulmonary Embolism; Shock
ORCID
0000-0003-2915-2369
Research at a Glance
Yale Co-Authors
Frequent collaborators of Akhil Khosla's published research.
Publications Timeline
A big-picture view of Akhil Khosla's research output by year.
Research Interests
Research topics Akhil Khosla is interested in exploring.
Inderjit Singh, MBChB, BMedSci, FRCP, FCCP, MD
Rachel Beekman, MD
Emily J. Gilmore, MD, FNCS, FACNS
Hamid Mojibian, MD
Mark Kulaga, MD
Charles Wira, MD
17Publications
130Citations
Pulmonary Embolism
Out-of-Hospital Cardiac Arrest
Publications
2023
Right Heart Failure in the Intensive Care Unit: Etiology, Pathogenesis, Diagnosis, and Treatment
Tarras E, Khosla A, Heerdt P, Singh I. Right Heart Failure in the Intensive Care Unit: Etiology, Pathogenesis, Diagnosis, and Treatment. Journal Of Intensive Care Medicine 2023, 40: 119-136. PMID: 38031338, DOI: 10.1177/08850666231216889.Peer-Reviewed Original ResearchCitationsAltmetricConceptsRight heart failureFailure patientsHeart failureTreatment optionsIntensive care unit settingMechanical circulatory support devicesIntensive care unitCirculatory support devicesCardio-pulmonary physiologyCare unitDifferent pharmacotherapiesUnit settingClinical guidancePathophysiological manifestationsCirculatory physiologyIntensivistsPatientsSupport devicesSupport optionsCirculatory systemHigh rateTreatmentDiagnosisFailureOptionsTemperature Control in the Era of Personalized Medicine: Knowledge Gaps, Research Priorities, and Future Directions
Beekman R, Khosla A, Buckley R, Honiden S, Gilmore E. Temperature Control in the Era of Personalized Medicine: Knowledge Gaps, Research Priorities, and Future Directions. Journal Of Intensive Care Medicine 2023, 39: 611-622. PMID: 37787185, DOI: 10.1177/08850666231203596.Peer-Reviewed Original ResearchCitationsConceptsHypoxic-ischemic brain injuryCardiac arrestPopulation-based thresholdsDuration of therapyCardiac arrest survivorsCause of deathRobust preclinical evidencePatient-centered careCritical future stepNeurologic outcomeNeuroprotective therapiesPreclinical evidenceArrest survivorsClinical equipoiseBrain injuryCurrent guidelinesFever preventionIndividualized targetOnly interventionTherapeutic windowInsufficient evidenceResearch prioritiesPersonalized approachMetabolic demandsCore temperatureHigh-Risk Pulmonary Embolism: Management for the Intensivist
Khosla A, Zhao Y, Mojibian H, Pollak J, Singh I. High-Risk Pulmonary Embolism: Management for the Intensivist. Journal Of Intensive Care Medicine 2023, 38: 1087-1098. PMID: 37455352, DOI: 10.1177/08850666231188290.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHigh-risk pulmonary embolismHigh-risk PE patientsPulmonary embolismRisk stratificationPE patientsTreatment optionsRisk pulmonary embolismMassive pulmonary embolismIntensivist’s perspectiveReperfusion therapySupportive careAcute managementPatientsIntensivistsSupport optionsEmbolismHigh rateCarePhysiological consequencesOutcomesTreatmentOptionsStratificationMorbidityTherapyValidation of the rCAST score and comparison to the PCAC and FOUR scores for prognostication after out-of-hospital cardiac arrest
Kim N, Kitlen E, Garcia G, Khosla A, Miller P, Johnson J, Wira C, Greer D, Gilmore E, Beekman R. Validation of the rCAST score and comparison to the PCAC and FOUR scores for prognostication after out-of-hospital cardiac arrest. Resuscitation 2023, 188: 109832. PMID: 37178901, DOI: 10.1016/j.resuscitation.2023.109832.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsPoor neurologic outcomeUnited States cohortHospital cardiac arrestOHCA patientsNeurologic outcomeCardiac arrestPost-cardiac arrest syndromePoor neurological outcomeScore predictive abilityHospital mortalityNeurological outcomeUnResponsiveness (FOUR) scorePoor outcomeRetrospective studyAccurate outcome predictionPrognostic performanceFull OutlineDeLong testOutcome predictionPatientsMortalityOutcomesScoresCohortPredictive ability
2022
Bedside monitoring of hypoxic ischemic brain injury using low-field, portable brain magnetic resonance imaging after cardiac arrest
Beekman R, Crawford A, Mazurek MH, Prabhat AM, Chavva IR, Parasuram N, Kim N, Kim JA, Petersen N, de Havenon A, Khosla A, Honiden S, Miller PE, Wira C, Daley J, Payabvash S, Greer DM, Gilmore EJ, Kimberly W, Sheth KN. Bedside monitoring of hypoxic ischemic brain injury using low-field, portable brain magnetic resonance imaging after cardiac arrest. Resuscitation 2022, 176: 150-158. PMID: 35562094, PMCID: PMC9746653, DOI: 10.1016/j.resuscitation.2022.05.002.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCardiac arrestBrain injuryHypoxic-ischemic brain injuryAdverse neurological outcomesIschemic brain injurySingle-center studyBrain magnetic resonanceBrain injury severityBoard-certified neuroradiologistsLow-field MRIFLAIR signal intensityNeurological outcomeCA patientsIll patientsMRI findingsCA survivorsCenter studyMRI examinationsClinical careHigh riskInjury severityPatientsSignal intensityBedside monitoringMR imagingRight heart thrombi (RHT) and clot in transit with concomitant PE management: Approach and considerations
Khosla A, Mojibian H, Assi R, Tantawy H, Singh I, Pollak J. Right heart thrombi (RHT) and clot in transit with concomitant PE management: Approach and considerations. Pulmonary Circulation 2022, 12: e12080. PMID: 35514771, PMCID: PMC9063956, DOI: 10.1002/pul2.12080.Peer-Reviewed Original ResearchCitationsAltmetricConceptsRight heart thrombusConcomitant pulmonary embolismPulmonary embolismHeart thrombusTreatment strategiesLimited clinical dataMultiple treatment strategiesMultiple medical specialtiesSystemic thrombolysisSurgical therapyExact incidenceRisk stratificationPoor outcomeUse of pointClinical dilemmaClinical dataTreatment considerationsPE managementCare ultrasoundMultiple specialtiesMedical specialtiesThrombusSpecialtiesAnticoagulationThrombolysisCatheter-directed embolectomy for massive pulmonary embolism in a pediatric patient
Chan SM, Gaupp F, Lee JM, Pollak JS, Khosla A. Catheter-directed embolectomy for massive pulmonary embolism in a pediatric patient. SAGE Open Medical Case Reports 2022, 10: 2050313x221112361. PMID: 35847425, PMCID: PMC9280839, DOI: 10.1177/2050313x221112361.Peer-Reviewed Original ResearchCitationsConceptsMassive pulmonary embolismPulmonary embolismPediatric patientsPulmonary Embolism Response TeamPediatric pulmonary embolismSystemic thrombolyticsPediatric populationTreatment paradigmEffective therapyAdult studiesInclusion criteriaHigh riskEmbolismAdult populationEmbolectomyPatientsResponse teamsMore researchChildrenRiskAnticoagulationThrombolyticsTherapyPopulationMortality
2014
Hypoglycemia in the Hospital: Systems-Based Approach to Recognition, Treatment, and Prevention
Varlamov EV, Kulaga ME, Khosla A, Prime DL, Rennert NJ. Hypoglycemia in the Hospital: Systems-Based Approach to Recognition, Treatment, and Prevention. Hospital Practice 2014, 42: 163-172. PMID: 25502140, DOI: 10.3810/hp.2014.10.1153.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsInpatient diabetes careImmediate adverse reactionsUnfavorable clinical outcomeAmerican Diabetes AssociationTransitions of careInpatient glycemic controlHealth care costsAdditional hospital resourcesCoordination of nutritionQuality improvement effortsAcute illnessGlycemic controlHospitalized patientsClinical outcomesPredispose patientsDiabetes AssociationHypoglycemic eventsDiabetes careAdverse reactionsEndocrine SocietyInsulin administrationPatient educationHospital resourcesHypoglycemiaHospital routine
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