Voluntary Faculty
Voluntary faculty are typically clinicians or others who are employed outside of the School but make significant contributions to department programs at the medical center or at affiliate institutions.
Voluntary rank detailsAlan S Kliger, MD
he/him/his
Clinical ProfessorDownloadHi-Res Photo
About
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Biography
Dr. Kliger is Clinical Professor of Medicine, Yale School of Medicine. He served as Sr. VP Medical Affairs for Yale New Haven Health System, and was its Chief Quality Officer. He also served the Hospital of St. Raphael, New Haven as Chairman of the Department of Medicine, and later its Chief Medical Officer. Dr. Kliger currently serves as the Chair of the American Society of Nephrology's Excellence in Patient Care Advisory Committee. Dr. Kliger has co-authored more than 190 publications in peer-reviewed journals, with particular interest in dialysis, quality measurement, quality improvement and patient safety.
Last Updated on December 04, 2023.
Appointments
Internal Medicine
Clinical ProfessorPrimary
Other Departments & Organizations
Education & Training
- MD
- SUNY Upstate Med Center (1970)
- BS
- City College of New York (1966)
Research
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Overview
Clinical research in areas of chronic kidney disease, hemo- and peritoneal dialysis, quality measures, quality improvement, patient safety
ORCID
0000-0002-9103-477X
Research at a Glance
Yale Co-Authors
Frequent collaborators of Alan S Kliger's published research.
Publications Timeline
A big-picture view of Alan S Kliger's research output by year.
Karl Insogna, MD, FACP
Arthur Rosenfield, MD
John Wysolmerski, MD
Fredric Finkelstein
Dana Dunne, MD, MHS, FACP, FIDSA
Mark Perazella, MD
57Publications
2,654Citations
Publications
2024
Human Factors Contributing to Infection Prevention in Outpatient Hemodialysis Centers: A Mixed Methods Study
Parker S, Jesso M, Wolf L, Leigh K, Booth S, Gualandi N, Garrick R, Kliger A, Patel P. Human Factors Contributing to Infection Prevention in Outpatient Hemodialysis Centers: A Mixed Methods Study. American Journal Of Kidney Diseases 2024, 84: 18-27. PMID: 38447708, PMCID: PMC11193600, DOI: 10.1053/j.ajkd.2023.12.024.Peer-Reviewed Original ResearchCitationsAltmetricConceptsInfection preventionMultidisciplinary teamDialysis facilitiesMixed methods studyOutpatient hemodialysis centersOutpatient dialysis facilitiesOutpatient dialysis settingInfection prevention effortsOutpatient dialysis centersDialysis centersOutpatient careStaff conversationsMethods studyPrevention effortsStaff encounterDialysis settingAxial codingPrevention barriersAbstractText Label="RATIONALEMacroergonomic approachWork system designHemodialysis centersPreventionSample sizeQuantitative data
2023
Approaches to Maximize Safety for Patients with Kidney Diseases after the End of COVID-19 Public Health Emergency
Silberzweig J, Kliger A, White D, Stark S, Kumar V. Approaches to Maximize Safety for Patients with Kidney Diseases after the End of COVID-19 Public Health Emergency. Clinical Journal Of The American Society Of Nephrology 2023, 19: 263-265. PMID: 37642955, PMCID: PMC10861095, DOI: 10.2215/cjn.0000000000000303.Peer-Reviewed Original ResearchAltmetricEffects of Spironolactone on Arrhythmias in Hemodialysis Patients: Secondary Results of the SPin-D Randomized Controlled Trial
Mc Causland F, Hsu J, Himmelfarb J, Ikizler T, Raj D, Mehrotra R, Waikar S, Kimmel P, Kliger A, Dember L, Charytan D, Kliger A, Charytan D, Mc Causland F, Robinson E, Waikar S, Williams M, Weiner D, Aurien-Blajeni E, Cinelli M, Nizam T, Rim S, Seok P, Smith C, Curtis J, Raj D, Regunathan-Shenk R, Sharma S, Ramezani A, Andrews S, Dumadag M, Franco C, Wing M, Himmelfarb J, Mehrotra R, Anderson L, Linke L, Manahan L, Ikizler T, Hung A, Cavanaugh K, Booker C, Brannon B, Clagett A, Ellis C, Dember L, Landis J, Anderson A, Hsu J, Cifelli D, Ballard S, Durborow M, Howard T, Kuzla N, Nessel L, Tierney A, Skali H, Solomon S, Rad A, Di Carli M, Gaber M, Foster C, Kimmel P, Kusek J. Effects of Spironolactone on Arrhythmias in Hemodialysis Patients: Secondary Results of the SPin-D Randomized Controlled Trial. Kidney360 2023, 4: e486-e495. PMID: 36763641, PMCID: PMC10278797, DOI: 10.34067/kid.0000000000000067.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsEffect of spironolactoneFrequency of bradycardiaMaintenance hemodialysisFollow-upPost Hoc AnalysisConduction blockArrhythmic eventsCardiovascular eventsMaintenance HDSudden deathHoc AnalysisIncidence of cardiovascular eventsAssociation of spironolactoneDose of spironolactoneRisk of cardiovascular eventsDouble-blind trialProportion of patientsPatients treated with maintenance HDRandomized Controlled TrialsGeneralized Estimating Equation modelsSpironolactone groupPlacebo-ControlledSpironolactone treatmentBradycardic eventsAge of participantsSome Lessons Learned for Kidney Failure Patients in the COVID-19 Pandemic
Kliger A, Silberzweig J, McNamara E, Stark S. Some Lessons Learned for Kidney Failure Patients in the COVID-19 Pandemic. Clinical Journal Of The American Society Of Nephrology 2023, 18: 946-948. PMID: 36723343, PMCID: PMC10356111, DOI: 10.2215/cjn.0000000000000090.Peer-Reviewed Original ResearchCitationsAltmetricKidney Transplant Practice in Pandemic Times
Kumar V, Leigh K, Kliger A, Roberts G, Mohan S, Leca N, Sawinski D, Josephson M, Mannon R, Lentine K. Kidney Transplant Practice in Pandemic Times. Clinical Journal Of The American Society Of Nephrology 2023, 18: 961-964. PMID: 36795033, PMCID: PMC10356143, DOI: 10.2215/cjn.0000000000000092.Peer-Reviewed Original ResearchCitationsAltmetric
2022
54 COVID-19 and Dialysis Patients
Silberzweig J, Kliger A. 54 COVID-19 and Dialysis Patients. 2022, 491-496. PMCID: PMC9335159, DOI: 10.1016/b978-0-323-79135-9.00054-9.ChaptersCitationsConceptsDialysis therapyIntermittent renal replacement therapyCOVID-19Continuous dialysis therapyAcute kidney injuryChronic kidney diseaseRenal replacement therapyAcute peritoneal dialysisAssociated risk factorsHome dialysis therapiesHigh rateDepartment of HealthKidney injuryDiabetes mellitusDialysis patientsFacility patientsPeritoneal dialysisKidney diseaseReplacement therapyDialysis programRisk factorsSevere diseaseMedical conditionsSubstantial burdenPatientsA randomized controlled pilot trial of anakinra for hemodialysis inflammation
Dember L, Hung A, Mehrotra R, Hsu J, Raj D, Charytan D, Mc Causland F, Regunathan-Shenk R, Landis J, Kimmel P, Kliger A, Himmelfarb J, Ikizler T, Consortium H. A randomized controlled pilot trial of anakinra for hemodialysis inflammation. Kidney International 2022, 102: 1178-1187. PMID: 35863559, PMCID: PMC9588554, DOI: 10.1016/j.kint.2022.06.022.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPatient-reported outcomesPlacebo groupAdverse eventsMedian decreaseHemodialysis patientsIL-6IL-1 receptor antagonistRate of adverse eventsEffect of anakinraPlacebo-controlled trialBaseline to weekAnti-cytokine therapyIL-1 inhibitionAssociated with morbidityAnakinra groupReceptor antagonistBetween-group differencesEfficacy outcomesAnakinraMaintenance hemodialysisRandomized Controlled Pilot TrialChronic inflammationEvaluate safetyPlaceboIL-1Moving from Evidence to Implementation of Breakthrough Therapies for Diabetic Kidney Disease
Tuttle KR, Wong L, St. Peter W, Roberts G, Rangaswami J, Mottl A, Kliger A, Harris RC, Gee PO, Fowler K, Cherney D, Brosius FC, Argyropoulos C, Quaggin SE. Moving from Evidence to Implementation of Breakthrough Therapies for Diabetic Kidney Disease. Clinical Journal Of The American Society Of Nephrology 2022, 17: 1092-1103. PMID: 35649722, PMCID: PMC9269635, DOI: 10.2215/cjn.02980322.Commentaries, Editorials and LettersCitationsAltmetricMeSH Keywords and ConceptsConceptsDiabetic kidney diseaseKidney disease careKidney diseaseHealth care systemDisease careKidney failureGlucagon-like peptide-1 receptor agonistsSodium-glucose cotransporter 2 inhibitorsPeptide-1 receptor agonistsAngiotensin-converting enzyme inhibitorBreakthrough therapiesMajor public health challengeHealth care system supportCare systemAngiotensin receptor blockersCotransporter 2 inhibitorsHalf of patientsPocket drug costsIndividual health care systemsPublic health challengeHealth care professionalsValue-based careEligible patientsMineralocorticoid antagonistsCardiovascular events
2021
Transforming the Care of Patients with Diabetic Kidney Disease
Brosius FC, Cherney D, Gee PO, Harris RC, Kliger A, Tuttle KR, Quaggin SE. Transforming the Care of Patients with Diabetic Kidney Disease. Clinical Journal Of The American Society Of Nephrology 2021, 16: 1590-1600. PMID: 34103350, PMCID: PMC8499007, DOI: 10.2215/cjn.18641120.Commentaries, Editorials and LettersCitationsAltmetricMeSH Keywords and ConceptsConceptsRenin-angiotensin system inhibitorsDiabetic kidney diseaseIrbesartan Diabetic Nephropathy TrialCare of patientsKidney diseaseSystem inhibitorsNew therapiesAngiotensin II Antagonist Losartan (RENAAL) trialAngiotensin II type 1 receptor blockerDiabetic kidney disease progressionType 1 receptor blockerCardiovascular protective therapiesReduction of EndpointsKidney disease progressionKidney protective effectsRenin-angiotensin systemDiabetic Nephropathy TrialRisk of deathHigh residual riskHealth care providersPowerful new therapiesNephropathy TrialReceptor blockersDevastating complicationAntihypertensive agentsSARS-CoV-2 Antibody Dynamics in Chronic Hemodialysis Patients
Thwin O, Grobe N, Ye X, Preciado P, Silva L, Cherif A, Wang Y, Kshirsagar A, Kliger A, Finkelstein F, Kotanko P. SARS-CoV-2 Antibody Dynamics in Chronic Hemodialysis Patients. Journal Of The American Society Of Nephrology 2021, 32: 770-770. DOI: 10.1681/asn.20213210s1770b.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
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Activities
activity NIH / NIDDK Steering Committee for Consortium: Hemodialysis Novel Therapies (HDNT)
2014 - PresentProfessional OrganizationsChairactivity National Quality Forum, Renal Standing Committee
07/01/2014 - 07/01/2023Professional OrganizationsMemberactivity National Quality Forum Renal Standing Committee
06/01/2014 - 07/01/2023Professional OrganizationsMemberDetailsNational Quality Organization reviewing and recommending measures for quality careactivity NIH / NIDDK Steering Committee for Consortium: Hemodialysis Novel Therapies (HDNT)
2014 - 2022Professional OrganizationsChair
Honors
honor Journal of the American Society of Nephrology Reviewer of the Year
11/02/2023National AwardAmerican Society of NephrologyDetailsUnited Stateshonor Jenny Kitsen Patient Safety Award
06/01/2022National AwardAmerican Association of Kidney PatientsDetailsUnited Stateshonor J. Michael Lazarus Distinguished Service Award
03/01/2018National AwardNational Kidney FoundationDetailsUnited Stateshonor Distinguished Nephrology Service Award
03/01/2016National AwardRenal Physicians AssociationDetailsUnited Stateshonor Maureen Lundin aakpRENALLIFE Award
03/03/2004National AwardAmerican Association of Kidney PatientsDetailsUnited States