Shufan Huo, MD, PhD
Postdoctoral AssociateAbout
Research
Publications
2025
Additive Effects of White Matter Hyperintensity and APOE ε4 Status on Risk of Incident Dementia in Two Large Longitudinal Cohorts
de Havenon A, Littig L, Clocchiatti‐Tuozzo S, Johnson I, Constantinescu S, Rivier C, Huo S, Kimberly W, Gomez‐Isla T, Kim Y, Stulberg E, Smith E, Rosand J, Falcone G, Sheth K, Brickman A. Additive Effects of White Matter Hyperintensity and APOE ε4 Status on Risk of Incident Dementia in Two Large Longitudinal Cohorts. Annals Of Neurology 2025 PMID: 41267647, DOI: 10.1002/ana.78103.Peer-Reviewed Original ResearchIncident all-cause dementiaDementia incidence ratesAll-cause dementiaApolipoprotein E e4 statusE4 statusHazard ratioRisk of incident all-cause dementiaRisk of incident dementiaWhite matter hyperintensitiesIncidence rateVascular risk managementDelay dementia onsetAdjusted hazard ratiosProspective cohort studyEffects of white matter hyperintensityApolipoprotein EAt-risk individualsCox proportional hazards modelsIncident dementiaDementia riskDementia onsetProportional hazards modelWhite matter hyperintensities burdensAtherosclerosis RiskARICSLAMF1 as a Risk Biomarker for Nontraumatic SAH: Evidence From a Multiomics Study.
Renedo D, Koo A, Sujijantarat N, Clocchiatti-Tuozzo S, Huo S, Acosta J, Hebert R, Gunel M, Sansing L, Sheth K, Falcone G, Matouk C, Rivier C. SLAMF1 as a Risk Biomarker for Nontraumatic SAH: Evidence From a Multiomics Study. Stroke 2025 PMID: 41221640, DOI: 10.1161/strokeaha.125.052604.Peer-Reviewed Original ResearchMendelian randomizationSubarachnoid hemorrhage riskIncident SAH casesNontraumatic subarachnoid hemorrhageSubarachnoid hemorrhageUK BiobankSmoking statusClinical priorityPrevention strategiesCellular expression profilesCox proportional hazards analysisProportional hazards analysisRisk predictionCis-protein quantitative trait lociCD4 naive cellsSAH casesRisk biomarkersSubarachnoid hemorrhage pathophysiologyAdaptive immune responsesHuman hematopoietic progenitorsFollow-upQuantitative trait lociSingle-cell transcriptome analysisRiskCerebrovascular eventsReply to “Genetic Risk, Drug Regimens, and the Limits of Equitable Translation”
Huo S, Falcone G. Reply to “Genetic Risk, Drug Regimens, and the Limits of Equitable Translation”. Annals Of Neurology 2025, 98: 1402-1403. PMID: 41104730, DOI: 10.1002/ana.78063.Peer-Reviewed Original ResearchCharacterizing Stroke Clots Using Single‐Cell Sequencing
Renedo D, Barak T, DeLong J, Acosta J, Sujijantarat N, Koo A, Rivier C, Clocchiatti-Tuozzo S, Huo S, Antonios J, Giles J, Falcone G, Sheth K, Hebert R, Gunel M, Sansing L, Navaratnam D, Matouk C. Characterizing Stroke Clots Using Single‐Cell Sequencing. Journal Of The American Heart Association 2025, 14: ejaha/2025/041738-t. PMID: 40878981, PMCID: PMC12553457, DOI: 10.1161/jaha.125.041738.Peer-Reviewed Original ResearchConceptsMulti-marker analysisGene expressionMulti-marker Analysis of GenoMic AnnotationCell type-specific gene expressionT cellsGenome-wide association studiesGene expression of cellsSingle-cell RNA sequencingPotential biomarkersTIMP1Genes associated with atherosclerosisHLA-DRB1*01Single-cell sequencingExpression of genesUpregulated expression of genesGene expression profilesCarotid atherosclerosisGenome annotationCD8 T cellsUpregulated expressionImmune cell compositionAssociation studiesNatural killer cellsImmune cell populationsLarge vessel occlusion strokePolygenic Resistance to Blood Pressure Treatment and Stroke Risk: Insights from the All of Us Research Program
Huo S, Rivier C, Clocchiatti‐Tuozzo S, Renedo D, Petersen N, de Havenon A, Meeker D, Zhao H, Ohno‐Machado L, Sheth K, Falcone G. Polygenic Resistance to Blood Pressure Treatment and Stroke Risk: Insights from the All of Us Research Program. Annals Of Neurology 2025 PMID: 40827941, DOI: 10.1002/ana.78009.Peer-Reviewed Original ResearchUs Research ProgramUncontrolled hypertensionSystolic BPGenetic riskSusceptibility to hypertensionRates of uncontrolled hypertensionPolygenic risk scoresAssociated with higher systolic BPOdds of uncontrolled hypertensionCox proportional hazards regressionUnited Kingdom BiobankGenetic association studiesHigh-risk individualsHigher systolic BPProportional hazards regressionBlood pressure treatmentIncident strokeStroke hazardBlood pressureHigher RatesSystolic blood pressureHypertensive adultsDiagnosed hypertensionBP medicationsHazards regressionAssociation of Polygenic Susceptibility to Hyperlipidemia With Cholesterol Control and Recurrent Stroke in Ischemic Stroke Survivors
Wu K, Huo S, Rivier C, Torres-Lopez V, Sharma R, de Havenon A, Worrall B, Sheth K, Falcone G. Association of Polygenic Susceptibility to Hyperlipidemia With Cholesterol Control and Recurrent Stroke in Ischemic Stroke Survivors. Neurology 2025, 105: e213966. PMID: 40825160, DOI: 10.1212/wnl.0000000000213966.Peer-Reviewed Original ResearchConceptsIschemic stroke survivorsStroke survivorsAssociated with riskSusceptible to hyperlipidemiaHigh riskUK BiobankResistant hyperlipidemiaCholesterol controlUncontrolled hyperlipidemiaSurvivors of ischemic strokeHigher risk of recurrent vascular eventsPolygenic risk scoresRisk factor controlRisk of recurrent vascular eventsAdverse genetic profileLow-density lipoprotein cholesterolRisk of acute coronary eventsGenetic association studiesRecurrent strokeClinical trajectoryGenetic risk variantsRisk of recurrent strokeAcute ischemic stroke survivorsPolygenic profilePrecision medicine toolsO-056 SLAMF1 and non-traumatic subarachnoid hemorrhage: a multi-omics investigation of risk
Renedo D, Koo A, Sujijantarat N, Clocchiatti-Tuozzo S, Huo S, Acosta J, Hebert R, Gunel M, Sansing L, Sheth K, Falcone G, Rivier C, Matouk C. O-056 SLAMF1 and non-traumatic subarachnoid hemorrhage: a multi-omics investigation of risk. 2025, a48.2-a49. DOI: 10.1136/jnis-2025-snis.56.Peer-Reviewed Original ResearchAPOE ε4 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban
Clocchiatti-Tuozzo S, Rivier C, Renedo D, Huo S, de Havenon A, Hawkes M, Gilmore E, Schwamm L, Sheth K, Gill T, Falcone G. APOE ε4 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban. JAMA Neurology 2025, 82: 808-816. PMID: 40549373, PMCID: PMC12186128, DOI: 10.1001/jamaneurol.2025.0182.Peer-Reviewed Original ResearchRisk of intracranial hemorrhagePopulation-based studyYears of follow-up dataApo E4Cox proportional hazards modelsAPOE e4 alleleIntracranial hemorrhageRisk prediction scoreCerebral amyloid angiopathyClinical decision-makingProportional hazards modelAtrial fibrillationIncreased risk of ICHMultivariate Cox proportional hazards modelMain OutcomesIncident intracranial hemorrhageEuropean ancestryCohort studyInclusion criteriaHistory of ischemic strokeAmyloid angiopathyE4 variantHazards modelIncreased riskE4 alleleDifferent Responses to Blood Pressure Reduction in Lobar and Deep Intracerebral Hemorrhage
Clocchiatti-Tuozzo S, Rivier C, Qureshi A, Renedo D, Huo S, Matouk C, Petersen N, de Havenon A, Sheth K, Rabinstein A, Falcone G, Hawkes M. Different Responses to Blood Pressure Reduction in Lobar and Deep Intracerebral Hemorrhage. Neurocritical Care 2025, 43: 607-615. PMID: 40293696, DOI: 10.1007/s12028-025-02269-2.Peer-Reviewed Original ResearchRenal adverse eventsDeep intracerebral hemorrhageIntensive BP reductionRisk of renal adverse eventsRisk of HEHematoma expansionBP reductionATACH-2Intracerebral hemorrhageLobar intracerebral hemorrhageFunctional outcomesAntihypertensive Treatment of Acute Cerebral Hemorrhage IIAcute spontaneous intracerebral hemorrhageAcute intracerebral hemorrhageSpontaneous intracerebral hemorrhageAssociated with reduced riskUnfavorable functional outcomeBlood pressure reductionRandomized clinical trialsMultivariate logistic regression resultsPost Hoc AnalysisAntihypertensive treatmentAdverse eventsClinical trialsIncreased riskPolygenic Resistance to Vascular Risk Factor Control in Stroke Survivors (S30.006)
Huo S, Rivier C, Clocchiatti-Tuozzo S, Renedo D, Torres-Lopez V, Sunmonu N, Petersen N, De Havenon A, Sheth K, Falcone G. Polygenic Resistance to Vascular Risk Factor Control in Stroke Survivors (S30.006). Neurology 2025, 104 DOI: 10.1212/wnl.0000000000208802.Peer-Reviewed Original Research
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